Congenital cytomegalovirus infections and glycoprotein B genotypes in live-born infants: a prevalence study in Turkey

Şahiner, Fatih; Çekmez, Ferhat; Çetınkaya, Merih; Kaya, Güven; Kalaycı, Tuğçe Özlem; Gunes, Omer; Şener, Kenan; Yapar, Mehmet; Tunç, Turan; Ecemiş, Tolga; Çekmez, Yasemin; Kubar, Ayhan

doi:10.3109/23744235.2015.1018316

Cited by 24 publications

(29 citation statements)

References 35 publications

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“…In comparison with developing countries with high maternal CMV seroprevalence, the frequency of cCMV infection that we found in the current study is in agreement with recently reported rates of infection from Brazil (0.6%) and China (0.7%), but in contrast to one report from Turkey (1.9%) ( 16 – 18 ). Differences in socioeconomic status and public health levels as well as ethnicity variations within populations, probably justify some of these reported differences between studies ( 19 ).…”

Section: Discussionsupporting

confidence: 93%

Neonatal screening for congenital cytomegalovirus infection in Tehran, Iran, using Guthrie cards

Noorbakhsh¹,

Farhadi²,

Haghighi³

et al. 2020

IJM

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Background and Objectives: Cytomegalovirus (CMV) constitutes the most common viral cause of congenital infections in newborns worldwide. There are a significant number of asymptomatic newborns with congenital CMV infection in Iran, which may develop long-term sequelae of infection. Unfortunately, limited data exsists from Iran on the rate of congenital CMV infection among neonates. The current study was aimed to investigate the prevalence of congenital CMV infection among Iranian neonates by testing Guthrie cards. Materials and Methods: Guthrie cards were collected from infants within 2 weeks of life, and total DNA was extracted from samples by thermal shock and evaluated for CMV DNA using nested-PCR assay. CMV infection in newborns was confirmed through a commercial CMV PCR kit. Infected infants underwent further evaluation at the hospital. Results: CMV infection was identified in four of 1174 infants (0.34%) which is approximately 3 cases per 1000 live births. Infected infants were asymptomatic at birth and had a normal hearing status similar to other children. There were no factors in relation with CMV infection among newborns. Conclusion: According to the results of this study, infected infants with congenital CMV infection could identify at early stage by testing Guthrie cards (within 21 days of life). Furthermore, since there is a lack of CMV knowledge in our popula- tion, educating and effective counseling by obstetricians/ gynecologists to the pregnant women are recommended.

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Section: Discussionsupporting

confidence: 93%

Neonatal screening for congenital cytomegalovirus infection in Tehran, Iran, using Guthrie cards

Noorbakhsh¹,

Farhadi²,

Haghighi³

et al. 2020

IJM

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“…The 0.7% congenital CMV infection prevalence that we report from China is significantly lower than that reported in 2 other large studies with good ascertainment methods conducted in populations with high seroprevalence in Brazil (1.1%, n = 8047, P = 0.003) and Turkey (1.9%, n = 944, P < 0.001). [ 11 , 22 ] The population we examined in China had much less exposure to young children (<7% in current study) than other populations as a result of China's unique 1-child policy. This is consistent with the lower IgM seroprevalence previously reported in China (0.5%) compared to Brazil (2.3%) among females of reproductive age.…”

Section: Discussionmentioning

confidence: 90%

Cohort study on maternal cytomegalovirus seroprevalence and prevalence and clinical manifestations of congenital infection in China

Wang

Zhang

et al. 2017

Medicine

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Congenital cytomegalovirus (CMV) infection is the leading viral cause of birth defects and developmental disabilities in developed countries. However, CMV seroprevalence and burden of congenital CMV infection are not well defined in China.Cohort of newborns from 5 birthing hospitals in 2 counties of Shandong Province, China, were enrolled from March 2011 to August 2013. Dried blood spots (DBS) and saliva were collected within 4 days after birth for IgG testing for maternal seroprevalence and real-time PCR testing for congenital CMV infection, respectively.Among 5020 newborns tested for CMV IgG, 4827 were seropositive, resulting in CMV maternal seroprevalence of 96.2% (95% confidence interval [CI]:95.6%–96.7%). Of the 10,933 newborns screened for congenital CMV infection, 75 had CMV detected, resulting in an overall prevalence of 0.7% (95% CI: 0.5%–0.9%), with prevalences of 0.4% (14/3995), 0.6% (66/10,857), and 0.7% (52/7761) for DBS, wet saliva, and dried saliva specimens screened, respectively. Prevalence of congenital CMV infection decreased with increasing maternal age (0.9%, 0.6%, and 0.3% among newborns delivered from mothers aged 16–25, 26–35, and >35 years, respectively; P = 0.03), and was higher among preterm infants than full term infants (1.3% vs 0.6%, P = 0.04), infants with intrauterine growth restriction (IUGR) than those without (1.8% vs 0.7%, P = 0.03), and twins or triplets than singleton pregnancies (2.8% vs 0.7%, P = 0.04). None of the 75 newborns exhibited symptomatic congenital CMV infection, and there was no difference in clinical characteristics and newborn hearing screening results between infants with and without congenital CMV infection at birth.Congenital CMV infection prevalence was lower and the clinical manifestations were milder in this relatively developed region of China compared to populations from other countries with similarly high maternal seroprevalence. Follow-up on children with congenital CMV infection will clarify the burden of disabilities from congenital CMV infection in China.

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“…Dünyada bu konuda farklı coğrafi bölgelerde ve farklı hasta gruplarında CMV gB genotiplerinin araştırıldığı çalışmalar yapılmaktadır [8][9][10] . Ülkemizde bu konudaki çalışmalar sınırlı olup, sadece yenidoğanda yapılmış tek bir çalışma bulunmaktadır 11 . Böbrek, kök hücre ve kalp transplant alıcılarını kapsayan bir çalışma henüz yapılmamıştır.…”

Section: Introductionunclassified

“…RFLP ile genotiplendirme yapılan 15 örneğin DNA , en sık olarak saptanan genotipler olarak bulunmuştur. Ülkemizde bu konuda yapılmış ulaşabilen tek çalışmada Şahiner ve arkadaşları11 konjenital CMV enfeksiyonu olan 18 bebekte %83.3 oranında gB1 genotipi saptamışlardır. Bizim çalışmamızda ise, 13 yenidoğanda saptanan genotipler sırasıyla gB1 (%38.4), gB3 (%30.8), gB2 (%15.4) ve gB4 (%7.7) olmuştur.…”

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Determination of Cytomegalovirus Glycoprotein B Genotypes in Different Geographical Regions and Different Patient Groups in Turkey

D¹,

Öngüt²,

Çolak³

et al. 2016

Mikrobiyol Bul

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Tüm dünyada yaygın olarak bulunan sitomegalovirus (cytomegalovirus; CMV), immün sistemi normal konaklarda sıklıkla belirtisiz enfeksiyonlara yol açarken, immün yetmezliği olanlarda ve fetusta çok ciddi komplikasyonlara neden olabilmektedir. CMV'nin zarf yapısında yer alan glikoprotein B (gB), bu proteini kodlayan UL55 genindeki polimorfi zmlere göre dört genotipe ayrılmaktadır. CMV gB geninde saptanan nükleotid polimorfi zmlerinin; virusun hücre tropizmini, konağın immün yanıtını ve sonuçta CMV'nin patogenezini etkileyebileceği düşünülmektedir. Bu araştırmanın amacı, Türkiye'nin farklı bölgelerinden ve farklı hasta gruplarından elde edilen CMV izolatlarının gB genotiplerinin belirlenmesidir. Çalışmaya,

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Congenital cytomegalovirus infections and glycoprotein B genotypes in live-born infants: a prevalence study in Turkey

Cited by 24 publications

References 35 publications

Neonatal screening for congenital cytomegalovirus infection in Tehran, Iran, using Guthrie cards

Neonatal screening for congenital cytomegalovirus infection in Tehran, Iran, using Guthrie cards

Cohort study on maternal cytomegalovirus seroprevalence and prevalence and clinical manifestations of congenital infection in China

Determination of Cytomegalovirus Glycoprotein B Genotypes in Different Geographical Regions and Different Patient Groups in Turkey

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