Congenital Epulis

Custer, R. Philip; Fust, John A.

doi:10.1093/ajcp/22.11.1044

Cited by 69 publications

(14 citation statements)

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“…In spite of the enigma regarding the cellular origin of a CGCE, it is largely considered to be a non-neoplastic lesion [8,19,36,47,48]. This can be supported by the clinical observations that the lesion has no growth potential after birth, its ability to regress spontaneously (when small lesions are involved), and the lack of recurrence even after incomplete excision [4,36,37,39].…”

Section: Discussionmentioning

confidence: 99%

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

2009

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Congenital granular cell epulis (CGCE), a rare benign lesion arising from the mucosa of the alveolar ridges of the jaws in newborns, has a clinical course characterized by lack of further growth after birth. Histomorphologically, it resembles a granular cell tumor (GCT) of the adult. The histogenesis of this lesion is unclear. We submitted a series of five CGCEs to a large panel of antibodies in order to trace the origin of the constituent granular cells. The resultant immunohistochemical profile showed positivity of these cells to vimentin, NKI/C3, and PGP9.5. This does not confirm any particular cell type for the histogenetic origin of CGCE but may rather reflect a local metabolic or reactive change, providing supporting evidence that the lesion is of a non-neoplastic nature. In addition, the granular cells were non-reactive for S-100, NGFR/p75, and inhibin-alpha, which further contributes to the distinction between a CGCE and the adult GCT.

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Section: Discussionmentioning

confidence: 99%

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

2009

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“…In their classic account of the congenital epulis Custer and Fust (1952) are unwilling to regard the lesions as true neoplasms and tend to regard them as a form of embryonal hamartoma, arising from the tooth bud. However, in both our cases dentition is normal to date.…”

Section: Discussionmentioning

confidence: 99%

Congenital epulis: its natural history.

O'Brian¹,

Pielou²

1971

Archives of Disease in Childhood

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“…The nature of the various oral granular cell lesions is also unclear. Although it has been suggested that granular cell myoblastoma and congenital epulis are identical lesions (Smith et al 1964), this view is not supported by Custer and Fust (1952) nor has it found gen- eral support in the literature. McCallum and Cappell (1957) consider the granular cells in myoblastomas and ameloblastomas to be similar, and Stout and Lattes (1967) believe there is no doubt that the granular cell epulis is a malformation of the enamel organ.…”

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confidence: 97%

Granular cells associated with the enamel organ of a developing tooth

Sunderland¹,

Sunderland²,

Smith³

1983

J Oral Pathology Medicine

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An accumulation of granular cells associated with the enamel organ of a developing deciduous, incisor tooth was noted during light microscopy (LM) of serial sections from the right half of a mandible from a stillborn, female infant of 37 weeks gestations. There was a break in continuity of the enamel matrix associated with the focus of granular cells, which appeared to be continuous with, and arise directly from, the cells of the stratum intermedium. The granular cells were very similar histologically to those of a congenital epulis but it is impossible to say whether the lesion would have developed sufficiently to present clinically as an epulis. Less probably, the granular cells might eventually have been associated with the subsequent development of a granular cell ameloblastoma or ameloblastic fibroma. If the lesion does represent an early stage in the formation of a congenital epulis, it would support the odontogenic theory of origin of the granular cells.

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Congenital Epulis

Cited by 69 publications

References 0 publications

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

Congenital epulis: its natural history.

Granular cells associated with the enamel organ of a developing tooth

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