Congenital hypotrichosis in Poll Dorset sheep

Mackie, J T; McIntyre, Bernard P.

doi:10.1111/j.1751-0813.1992.tb07490.x

Cited by 7 publications

(6 citation statements)

References 3 publications

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“…The literature reports a few cases of congenital hypotrichosis in the ovine breeds Australian Polled Dorset [7,10], Karakul [11], and Valle del Belice [9]. So far no molecular study has been carried out in the ovine species.…”

Section: Introductionmentioning

confidence: 99%

The hairless (hr) gene is involved in the congenital hypotrichosis of Valle del Belice sheep

Finocchiaro¹,

Portolano²,

Damiani

et al. 2003

Genet Sel Evol

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-Congenital hypotrichosis in mammalian species consists of partial or complete absence of hair at birth. The hairless gene is often responsible for this disorder in men, mice and rats. Recent experimental data on Valle del Belice sheep reared in Sicily for milk production, support the genetic control of the ovine hypotrichosis as a Mendelian recessive trait. The ovine hairless gene was chosen as the candidate gene involved in this disorder. Blood samples were collected from Valle del Belice sheep with the normal and hypotrichotic phenotypes. Almost the entire hairless gene was successfully amplified using the long PCR technique. Unrelated sheep with differing phenotypes were randomly chosen for sequencing the amplified products. Different mutations related to the hypotrichotic phenotype were found in exon 3. In fact, sequencing revealed an A/T transversion at position 739, a G/A transition at position 823, and a C/T transition at position 1312. From these nucleotide exchanges, three substitutions of the processed mature protein were deduced at the amino acid positions 247 (Thr/Ser), 275 (Ala/Thr), and 438 (Gln/Stop). A PCR-SSCP based test was developed in order to detect the last mutation, which is responsible for the hypotrichotic phenotype.hairless gene / congenital hypotrichosis / ovine / Valle del Belice sheep

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Section: Introductionmentioning

confidence: 99%

The hairless (hr) gene is involved in the congenital hypotrichosis of Valle del Belice sheep

Finocchiaro¹,

Portolano²,

Damiani

et al. 2003

Genet Sel Evol

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“…These include hypotrichosis in the Arabian horse and its crosses, and mane and tail hair dystrophy in the Appaloosa (Fadok 1995b). Follicular dysplasias causing hypotrichosis and alopecia are reported in other species including the cow (Miller and Scott 1990;Mansell 1999), sheep (Mackie and McIntyre 1992) and dog (Miller 1990;Beco et al 1996). However, to date, no report on cases in the horse has been published, although anecdotal evidence exists for its occurrence (Scott 1999).…”

Section: Introductionmentioning

confidence: 99%

Alopecia due to colour‐dilute follicular dysplasia in a horse

Henson

Stidworthy

2003

Equine Veterinary Education

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“…Other histologic examinations have demonstrated a decrease in follicle density, skin thickness, hair diameter, and size and number of sweat and sebaceous glands (Bracho et al, 1984;Hanna and Ogilvie, 1989). Becker et al (1963) reported that sweat glands were dilated and cystic while others observed normal sweat glands (Mackie and McIntyre, 1992). Other findings in sheep include an absence of fibers in follicles, keratotic follicles, hypertrophy and hyperplasia of sebaceous glands and epidermis, and epidermal hyperkeratosis (Mackie and McIntyre, 1992).…”

mentioning

confidence: 99%

“…Becker et al (1963) reported that sweat glands were dilated and cystic while others observed normal sweat glands (Mackie and McIntyre, 1992). Other findings in sheep include an absence of fibers in follicles, keratotic follicles, hypertrophy and hyperplasia of sebaceous glands and epidermis, and epidermal hyperkeratosis (Mackie and McIntyre, 1992).…”

mentioning

confidence: 99%

Congenital Hypotrichosis in a White-Tailed Deer Fawn from South Dakota

Zimmerman

Jenks

Holler

et al. 2004

Journal of Wildlife Diseases

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On 1 October 2001, a 4-mo-old male white-tailed deer (Odocoileus virginianus) fawn was collected in Day County, South Dakota (USA), by South Dakota Department of Game, Fish and Parks personnel. The fawn had sparse hair development on the ventral thorax, the lateral caudal and caudal aspects of the rear legs, the muzzle, around the eyes, and inside the ears. Remaining skin surfaces were devoid of hair. Histologic examination revealed normal hair follicle density although follicles were empty or contained keratin debris and fragments of hair shaft. The epidermis of the fawn was mildly thickened and melanin pigment was prominent within deep layers of the epidermis. Based on histologic examination, the deer was diagnosed with congenital hypotrichosis. Although this condition has been reported in domestic species and humans, this specimen represents the first documented case of congenital hypotrichosis in a cervid.

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Congenital hypotrichosis in Poll Dorset sheep

Cited by 7 publications

References 3 publications

The hairless (hr) gene is involved in the congenital hypotrichosis of Valle del Belice sheep

The hairless (hr) gene is involved in the congenital hypotrichosis of Valle del Belice sheep

Alopecia due to colour‐dilute follicular dysplasia in a horse

Congenital Hypotrichosis in a White-Tailed Deer Fawn from South Dakota

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