Congenital nuclear cataracts and uveitis in HIV-transgenic mice

Mózes, Miklós; Bryant, Joseph; Franks, Roberta; Chan, Chi‐Chao; Kopp, Jeffrey B.

doi:10.1038/sj.eye.6700101

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“…The measurement of PPI in the HIV-1 Tg rat also provides the opportunity to assess general sensory system alterations, which are commonly observed in transgenic animals, but not always appropriately addressed in experimental designs. One of the readily apparent phenotypes of the HIV-1 Tg rat (and mouse, see Mozes et al 2002) is cataracts, which present potential limitations in testing models of HAND with the HIV-1 Tg rat via its visual system. It is therefore critical to assess the basic ability to detect visual stimuli in order to design experiments appropriately.…”

Section: Introductionmentioning

confidence: 99%

Time and time again: Temporal processing demands implicate perceptual and gating deficits in the HIV-1 transgenic rat

Moran¹,

Booze²,

Mactutus³

2014

Neurotoxicology and Teratology

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Section: Introductionmentioning

confidence: 99%

Time and time again: Temporal processing demands implicate perceptual and gating deficits in the HIV-1 transgenic rat

Moran¹,

Booze²,

Mactutus³

2014

Neurotoxicology and Teratology

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Eye pathologies in neonates

Mansoor

Ahmed

2016

Int J Ophthalmol

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In the United Kingdom, newborn assessment incorporates a screening eye examination for any structural abnormalities, observation of neonate's visual behaviour and direct ophthalmoscopy examination looking for red reflex. Early identification and immediate management of eye related pathologies should commence soon after birth as early diagnosis and prompt intervention may have significant impact on the prognosis for many potentially blinding but treatable disorders such as congenital cataracts and retinoblastoma. If left undetected and untreated, such problems may potentially lead to irreversible damage to the vision which persists into adulthood resulting in lack of self-confidence together with difficulties in educational attainment and job opportunities.

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Congenital nuclear cataracts and uveitis in HIV-transgenic mice

Cited by 2 publications

References 22 publications

Time and time again: Temporal processing demands implicate perceptual and gating deficits in the HIV-1 transgenic rat

Time and time again: Temporal processing demands implicate perceptual and gating deficits in the HIV-1 transgenic rat

Eye pathologies in neonates

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