Congenital Syphilis in Russia

Salakhov, Edward; Tikhonova, Lilia; Southwick, K; Shakarishvili, Anna; Ryan, Caroline; Hillis, Susan D.

doi:10.1097/01.olq.0000109516.47951.b8

Cited by 20 publications

(2 citation statements)

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“…A multi-centre retrospective cohort study in Russia reported a RR for preterm birth of 0.32 (95% c.i. 0.26 – 0.95) comparing adequately treated women to untreated women [38]. One small South African study observed a RR 0.08 (0.01 – 1.24) comparing treated to untreated women [37].…”

Section: Resultsmentioning

confidence: 99%

Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality

et al. 2011

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BackgroundGlobally syphilis is an important yet preventable cause of stillbirth, neonatal mortality and morbidity.ObjectivesThis review sought to estimate the effect of detection and treatment of active syphilis in pregnancy with at least 2.4MU benzathine penicillin (or equivalent) on syphilis-related stillbirths and neonatal mortality.MethodsWe conducted a systematic literature review of multiple databases to identify relevant studies. Data were abstracted into standardised tables and the quality of evidence was assessed using adapted GRADE criteria. Where appropriate, meta-analyses were undertaken.ResultsModerate quality evidence (3 studies) supports a reduction in the incidence of clinical congenital syphilis of 97% (95% c.i 93 – 98%) with detection and treatment of women with active syphilis in pregnancy with at least 2.4MU penicillin. The results of meta-analyses suggest that treatment with penicillin is associated with an 82% reduction in stillbirth (95% c.i. 67 – 90%) (8 studies), a 64% reduction in preterm delivery (95% c.i. 53 – 73%) (7 studies) and an 80% reduction in neonatal deaths (95% c.i. 68 – 87%) (5 studies). Although these effect estimates were large and remarkably consistent across studies, few of the studies adjusted for potential confounding factors and thus the overall quality of the evidence was considered low. However, given these large observed effects and a clear biological mechanism for effectiveness the GRADE recommendation is strong.ConclusionDetection and appropriate, timely penicillin treatment is a highly effective intervention to reduce adverse syphilis-related pregnancy outcomes. More research is required to identify the most cost-effective strategies for achieving maximum coverage of screening for all pregnant women, and access to treatment if required.

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Section: Resultsmentioning

confidence: 99%

Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality

et al. 2011

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“…La Organización Mundial de la Salud estima que 12 millones de nuevos casos de sífilis ocurren cada año (Gerbase et al, 1998). La gran mayoría de estos se ven en países en desarrollo, pero también se ha observado un aumento de casos nuevos en Europa del Este (Salakhov et al, 2004). La sífilis congénita es motivo especial de preocupación en los países en desarrollo, donde la falta de pruebas prenatales y el tratamiento antibiótico de mujeres embarazadas infectadas resulta en la infección congénita al feto.…”

Section: Discussionunclassified

Niveles de anticuerpos de Treponema palidium en adultos mayores peruanos deteriorio cognitivo no amnésico leve en convivencia comunitaria

2023

BMSA

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Syphilis (Treponema pallidum) is a chronic disease acquired by direct contact, generally sexual, with active primary or secondary lesions. The World Health Organization estimates that 12 million new cases of syphilis occur each year. The vast majority of these are seen in developing countries. Humans are initially infected primarily at the anogenital level; however, the eruption of secondary syphilis is a clear indication that the organisms are spreading widely from the primary site of contact. In addition to the above, syphilis has also been associated with mild cognitive impairment (NAMCI). The objective of this work was to determine the cognitive performance of healthy older adults (AM) in a community in Peru with mild memory problems that affected their condition. To this end, 574 AM were evaluated using the Mental State (MMSE) and Geriatric Depression (Yesavage) tests. Of the 574 elderly, 74 adults with mild non-amnestic cognitive impairment due to their account or history of venereal disease course and at least one positive VRDL test were included. The weighted general seroprevalence of antitreponemal antibodies in the study population was 32.43% (95% CI 21.091-41.774), with 100% correspondence between the VTDL and MHA-Tp tests in older adults and naMCI with a history of disease course. venereal or reactive VRDL test. When reviewing the sociodemographic and clinical characteristics of the study groups, it was observed that the subjects had a high level of education, had no family history, and exhibited few diseases.

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Infection

Goldenberg

McClure

2011

Stillbirth: Prediction, Prevention and Management

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Congenital Syphilis in Russia

Abstract: In Russia, maternal risk factors and perinatal consequences for epidemiologic cases of CS resembled those of clinical cases. Expanding national reporting to include epidemiologic cases would strengthen CS prevention and monitoring.

Cited by 20 publications

References 22 publications

Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality

Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality

Niveles de anticuerpos de Treponema palidium en adultos mayores peruanos deteriorio cognitivo no amnésico leve en convivencia comunitaria

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