The aim of this study was to identify the popular use of medicinal plants in Southeast Pará. A semi-structured study was carried out where a questionnaire composed of questions related to the socioeconomic profile, use, form, and frequency of use of medicinal plants was applied during visits to the homes of residents of the region. The research was approved by the Research Ethics Committee of the Federal University of Pará. Among the 153 respondents, they were between 18 and 80 years old, most of them female (71.8%). 62% two individuals declared themselves brown, followed by white (29.4%) and black (8.4%). Most people had completed elementary school, were married, and their per capita income was approximately one minimum wage. 98% reported using medicinal plants without taking care of their health. The indication for use is mostly by relatives and the most recommended plants are Mastruz, Ginger, Chamomile, Lemon balm, Slug, Chile Boldo. The data show a considerable use of products derived from medicinal plants and, therefore, health education strategies are necessary for more vulnerable populations and less developed regions of the country.