Conjugation of paclitaxel to C-6 hexanediamine-modified hyaluronic acid for targeted drug delivery to enhance antitumor efficacy

Chen, Yangjian; Peng, Fujun; Song, Xiaoda; Wu, Jicheng; Yao, Wei; Gao, Xiangdong

doi:10.1016/j.carbpol.2017.09.017

Cited by 55 publications

(35 citation statements)

References 37 publications

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“…Hence, HA-conjugated curcumin may be useful to treat diabetic wounds [182]. Finally, the most promising and thoroughly studied conjugations of active ingredients to HA involve antitumoral agents, which can be strategically carried to malignant cells by hyaluronan, as explained in Section 6.2 [179,183].…”

Section: Applications Of Ha and Its Derivativesmentioning

confidence: 99%

“…Additionally, HA-coated chitosan nanoparticles have been found to promote 5-fluorouracil delivery into tumor cells that overexpress the CD44 receptor [196]. Further studies have displayed that a novel unsaturated derivative of HA [209] and different types of HA-paclitaxel conjugates [179,183] have a great potential as anticancer therapies.…”

Section: Applications Of Ha and Its Derivativesmentioning

confidence: 99%

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Hyaluronic Acid in the Third Millennium

et al. 2018

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Abstract:Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid is almost ubiquitous in humans and in other vertebrates. HA is involved in many key processes, including cell signaling, wound reparation, tissue regeneration, morphogenesis, matrix organization and pathobiology, and has unique physico-chemical properties, such as biocompatibility, biodegradability, mucoadhesivity, hygroscopicity and viscoelasticity. For these reasons, exogenous HA has been investigated as a drug delivery system and treatment in cancer, ophthalmology, arthrology, pneumology, rhinology, urology, aesthetic medicine and cosmetics. To improve and customize its properties and applications, HA can be subjected to chemical modifications: conjugation and crosslinking. The present review gives an overview regarding HA, describing its history, physico-chemical, structural and hydrodynamic properties and biology (occurrence, biosynthesis (by hyaluronan synthases), degradation (by hyaluronidases and oxidative stress), roles, mechanisms of action and receptors). Furthermore, both conventional and recently emerging methods developed for the industrial production of HA and its chemical derivatization are presented. Finally, the medical, pharmaceutical and cosmetic applications of HA and its derivatives are reviewed, reporting examples of HA-based products that currently are on the market or are undergoing further investigations.

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Section: Applications Of Ha and Its Derivativesmentioning

confidence: 99%

Section: Applications Of Ha and Its Derivativesmentioning

confidence: 99%

Hyaluronic Acid in the Third Millennium

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Hence, HA conjugated curcumin may be useful to treat diabetic wounds [182]. Finally, the most promising and thoroughly studied conjugations of active ingredients to HA involve antitumoral agents, which can be strategically carried to malignant cells by hyaluronan, as explained in the subsection 6.2 [179,183].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…Additionally, HA-coated chitosan nanoparticles have been found to promote 5-fluorouracil delivery into tumor cells that overexpress CD44 receptor [196]. Further studies have displayed that a novel unsaturated derivative of HA [209] and different types of HA-paclitaxel conjugates [179,183] have a great potential as anticancer therapies.…”

Section: Cancer Therapymentioning

confidence: 99%

Hyaluronic Acid in the 3<sup>rd</sup> Millennium

Fallacara¹,

Baldini²,

Manfredini³

et al. 2018

Preprint

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Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid is almost ubiquitary in humans and in other vertebrates. HA is involved in many key processes -including cell signaling, wound reparation, tissue regeneration, morphogenesis, matrix organization and pathobiology-, and has unique physico-chemical properties -such as biocompatibility, biodegradability, mucoadhesivity, hygroscopicity and viscoelasticity. For these reasons, exogenous HA has been investigated as drug delivery system and treatment in cancer, ophthalmology, arthrology, pneumology, rhinology, urology, aesthetic medicine and cosmetic. To improve and customize its properties and applications, HA can be subjected to chemical modifications: conjugation and crosslinking. The present review gives an overview regarding HA, describing its history, physico-chemical, structural and hydrodynamic properties, and biology -occurrence, biosynthesis (by hyaluronan synthases), degradation (by hyaluronidases and oxidative stress), roles, mechanisms of action and receptors. Furthermore, both conventional and recently emerging methods developed for the industrial production of HA and its chemical derivatization are presented. Finally, the medical, pharmaceutical and cosmetic applications of HA and its derivatives are reviewed, reporting examples of HA-based products which currently are on the market or are undergoing further investigations.

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“…In recent decades, significant attention has been focused on the natural and synthetic polymers such as poly-caprolactone (PCL), polylactide (PLA) and poly(lactide-co-glycolide) (PLGA) because of their worthy biocompatibility, biodegradability and ability to prolong drug release [10][11][12]. Among them, chitosan is a favorable type of natural polymers that used in drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of pH Sensitive Novel Anticancer Drug Carrier Based on Magnetic Chitosan Quartets

et al. 2019

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Chitosan-coated magnetic nanoparticles are an appropriate drug delivery method which can improve the therapeutic properties of chemotherapy agents and also can be useful as MRI contrast agent for early cancer diagnosis. This research discovers the optimization of the possible therapeutic effects of Chitosan- citric acid- Fe3O4- CUR quartets. Chitosan as a natural polymer can use to encapsulate citric acid modified Fe3O4 nanoparticles. The successful preparation of CUR-loaded nano-carriers was confirmed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM) techniques. Moreover, the hemolysis test was used for the study of hemobiocompatibility. The loading capacity and encapsulation efficiency of CUR molecules were 11±0.09% and 49.5±0.41%, respectively. The anticancer effect of the void of CUR and CUR-loaded nano-carriers were compared by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on the treated MCF-7 cell lines. It can be concluded that the use of these nanoparticles are a better and more efficient approach for the controlled and slow release of CUR in the cancer treatment.

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Conjugation of paclitaxel to C-6 hexanediamine-modified hyaluronic acid for targeted drug delivery to enhance antitumor efficacy

Cited by 55 publications

References 37 publications

Hyaluronic Acid in the Third Millennium

Hyaluronic Acid in the Third Millennium

Hyaluronic Acid in the 3<sup>rd</sup> Millennium

Preparation and Evaluation of pH Sensitive Novel Anticancer Drug Carrier Based on Magnetic Chitosan Quartets

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