Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Yamazaki, C.; Miyamoto, Rie; Hoshino, Katsuaki; Fukuda, Yuri; Sasaki, Izumi; Saito, Masuyoshi; Ishiguchi, Hironori; Yano, Takahiro; Sugiyama, Takahiro; Hemmi, Hiroaki; Tanaka, Takashi; Hamada, Eri; Hirashima, Takeo; Amakawa, Ryuichi; Fukuhara, Shirou; Nomura, Shosaku; Ito, Tomoki; Kaisho, Tsuneyasu

doi:10.1016/j.bbrc.2010.06.029

Cited by 42 publications

(38 citation statements)

References 27 publications

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“…Gene expression analyses combined with the discovery of novel phenotypic markers and the demonstration of functional similarities has so far allowed us not only to define common phenotypic markers of cDC subsets in the different mouse tissues, but also to suggest some homologies between mouse and human DC [18,[44][45][46][47][48][49][50]. Firstly, phenotypic similarities between mouse CD8a + cDC1 and human CD141 + cDC [48][49][50][51][52], indicated that these two subsets were homologous (we will term them both cDC1 from now).…”

Section: Xcr1 + Cadm1 + Cdc1 Across Speciesmentioning

confidence: 96%

“…Firstly, phenotypic similarities between mouse CD8a + cDC1 and human CD141 + cDC [48][49][50][51][52], indicated that these two subsets were homologous (we will term them both cDC1 from now). Similar to murine cDC1, human CD141 + DC (cDC1) in LT, NLT and blood specifically express XCR1 [45][46][47]53,54], CADM1 [43,51] and CLEC9A [48][49][50]52,55]. While informative, it should be noted that CLEC9A may be unreliably expressed, for example in the gut lamina propria [56], and in inflamed or infected tissues, where CLEC9A membrane expression is lost when human cDC1 mature in response to TLR3 triggering [57].…”

Section: Xcr1 + Cadm1 + Cdc1 Across Speciesmentioning

confidence: 98%

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Aligning bona fide dendritic cell populations across species

Dutertre

Wang

Ginhoux

2014

Cellular Immunology

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Section: Xcr1 + Cadm1 + Cdc1 Across Speciesmentioning

confidence: 96%

Section: Xcr1 + Cadm1 + Cdc1 Across Speciesmentioning

confidence: 98%

Aligning bona fide dendritic cell populations across species

Dutertre

Wang

Ginhoux

2014

Cellular Immunology

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“…4B). XCR1 + DCs are exclusively present among the CD8 + subset of cDCs and represent 70-80% of the CD8 + DCs in the spleen (33,34). The XCR1 + DCs are found in the red pulp, marginal zone, and .…”

Section: Cd40l On Cd4mentioning

confidence: 99%

Invariant NKT Cells Induce Plasmacytoid Dendritic Cell (DC) Cross-Talk with Conventional DCs for Efficient Memory CD8+ T Cell Induction

Shimizu

Asakura

Shinga

et al. 2013

The Journal of Immunology

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A key goal of vaccine immunotherapy is the generation of long-term memory CD8+ T cells capable of mediating immune surveillance. We discovered a novel intercellular pathway governing the development of potent memory CD8+ T cell responses against cell-associated Ags that is mediated through cross-presentation by XCR1+ dendritic cells (DCs). Generation of CD8+ memory T cells against tumor cells pulsed with an invariant NKT cell ligand depended on cross-talk between XCR1+ and plasmacytoid DCs that was regulated by IFN-α/IFN-αR signals. IFN-α production by plasmacytoid DCs was stimulated by an OX40 signal from the invariant NKT cells, as well as an HMGB1 signal from the dying tumor cells. These findings reveal a previously unknown pathway of intercellular collaboration for the generation of tumor-specific CD8+ memory T cells that can be exploited for strategic vaccination in the setting of tumor immunotherapy.

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“…multicolor histological images suggested that these cross-presenting DC subsets were preferentially accumulated in deep areas of the T-cell zone in the SDLNs (12). Other studies directly visualized both DC subsets by histological analyses of chemokine (C motif) receptor 1 (XCR1) expression, which is selectively and highly expressed in both LN-resident DCs and migratory DCs (13)(14)(15)(16) + T-cell activation.…”

Section: Significancementioning

confidence: 99%

Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node

Kitano

Yamazaki

Takumi

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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109

108

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Dendritic cells (DCs) are antigen-presenting cells specialized for activating T cells to elicit effector T-cell functions. Cross-presenting DCs are a DC subset capable of presenting antigens to CD8+ T cells and play critical roles in cytotoxic T-cell-mediated immune responses to microorganisms and cancer. Although their importance is known, the spatiotemporal dynamics of cross-presenting DCs in vivo are incompletely understood. Here, we study the T-cell zone in skin-draining lymph nodes (SDLNs) and find it is compartmentalized into regions for CD8 + T-cell activation by cross-presenting DCs that express the chemokine (C motif) receptor 1 gene, Xcr1 and for CD4 + T-cell activation by CD11b + DCs. Xcr1-expressing DCs in the SDLNs are composed of two different populations: migratory (CD103 hi ) DCs, which immigrate from the skin, and resident (CD8α hi ) DCs, which develop in the nodes. To characterize the dynamic interactions of these distinct DC populations with CD8 + T cells during their activation in vivo, we developed a photoconvertible reporter mouse strain, which permits us to distinctively visualize the migratory and resident subsets of Xcr1-expressing DCs. After leaving the skin, migratory DCs infiltrated to the deep T-cell zone of the SDLNs over 3 d, which corresponded to their half-life in the SDLNs. Intravital two-photon imaging showed that after soluble antigen immunization, the newly arriving migratory DCs more efficiently form sustained conjugates with antigen-specific CD8 + T cells than other Xcr1-expressing DCs in the SDLNs. These results offer in vivo evidence for differential contributions of migratory and resident cross-presenting DCs to CD8 + T-cell activation.dendritic cell | CD8 + T cell | cross-presentation | intravital two-photon imaging | photoconversion

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Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Cited by 42 publications

References 27 publications

Aligning bona fide dendritic cell populations across species

Aligning bona fide dendritic cell populations across species

Invariant NKT Cells Induce Plasmacytoid Dendritic Cell (DC) Cross-Talk with Conventional DCs for Efficient Memory CD8+ T Cell Induction

Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node

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