Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study

Abstract

ObjectivesTo assess the risks of myocardial infarction, stroke, peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter and heart failure in patients with constipation compared with a general population cohort.DesignPopulation-based matched cohort study.SettingAll Danish hospitals and hospital outpatient clinics from 2004 to 2013.ParticipantsPatients with a constipation diagnosis matched on age, sex and calendar year to 10 individuals without constipation from the general population.Main outcomes measuresComorbidity-adjusted and medication-adjusted hazard ratios (aHRs) for cardiovascular outcomes based on Cox regression analysis.Results83 239 patients with constipation were matched to 832 384 individuals without constipation. The median age at constipation diagnosis was 46.5% and 41% were men. Constipation was strongly associated with venous thromboembolism (aHR 2.04, 95% CI 1.89 to 2.20), especially splanchnic venous thrombosis (4.23, 95% CI 2.45 to 7.31). Constipation was also associated with arterial events, including myocardial infarction (1.24, 95% CI 1.14 to 1.35), ischaemic stroke (1.50, 95% CI 1.41 to 1.60), haemorrhagic stroke (1.46, 95% CI 1.26 to 1.69), peripheral artery disease (1.34, 95% CI 1.20 to 1.50), atrial fibrillation or atrial flutter (1.27, 95% CI 1.20 to 1.34) and heart failure (1.52, 95% CI 1.42 to 1.62). The associations were strongest during the first year after the constipation diagnosis and strengthened with an increased number of laxative prescriptions.ConclusionsConstipation was associated with an increased risk of several cardiovascular diseases, in particular venous thromboembolism.

Oral Administration of <i>Euglena Gracilis</i> Z Alleviates Constipation and Cardiac Dysfunction in a Mouse Model of Isoproterenol-Induced Heart Failure

“…13 A large population-based cohort study revealed that constipation was associated with an increased risk of HF. 14 Therefore, it is important to manage and prevent constipation in HF patients.…”

Diagnosis and Treatment of Elderly and Senile Chronic Constipation: an Expert Consensus

“…Крупное популяционное когортное исследование с участием более 83 тыс. пациентов после поправок на коморбидность и лекарственную терапию продемонстрировало ассоциации хронического запора с венозными тромбоэмболическими осложнениями (ОР 2,04), инфарктом миокарда (ОР 1,24), ишемическим (ОР 1,50) и геморрагическим инсультами (ОР 1,46), а также заболеваниями периферических артерий (ОР 1,34), фибрилляцией/ трепетанием предсердий (ОР 1,27) и сердечной недостаточностью (ОР 1,52) [12]. В национальном когортном исследовании с участием 237 тыс.…”

Prospective assessing metabolic abnormalities, lifestyle and dietary pattern in a Chinese population with heart failure: the MALD-HF study protocol

“… 14 A previous study found constipation was associated with the increased risk of HF. 15 However, it is unclear about the contribution of constipation and dietary patterns to the prognosis of HF.…”

“…Constipation is associated with age, diabetes mellitus, hypertension and a lack of exercise, which are risk factors for CVD 14. A previous study found constipation was associated with the increased risk of HF 15. However, it is unclear about the contribution of constipation and dietary patterns to the prognosis of HF.…”