Constituents of Shashen (<i>Adenophora axilliflora</i>)

Du, Shang-jiang; Gariboldi, Pierluigi; Jommi, G.

doi:10.1055/s-2007-969164

Cited by 11 publications

(3 citation statements)

References 5 publications

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“…The molecular formula depicts the presence of six degrees of unsaturation, out of them one can be satisfied by an olefinic function. The presence of seven methyl singlets and an olefinic function in the 1H-NMR spectrum revealed that Lupeol is pentacylic triterpenoidal type in nature [6, 15]. Study conducted by Martelanc et al, using high-performance liquid chromatographic (HPLC) method with UV and mass spectrometric [MS] showed that Lupeol exhibits a parent ion peak at m/z 409 [M+H-18][+]] [16].…”

Section: Chemical Structure and Analysismentioning

confidence: 99%

Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene

2009

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In the Western world, an average of 250 mg per day of triterpenes (member of phytosterol family), largely derived from vegetable oils, cereals, fruits and vegetables is consumed by humans. During the last decade, there has been an unprecedented escalation of interest in triterpenes due to their cholesterol-lowering properties and evidence of this phenomenon include at least 25 clinical studies, 20 patents and at least 10 major commercially triterpene-based products currently being sold all around the world. Lupeol a triterpene [also known as Fagarsterol] found in white cabbage, green pepper, strawberry, olive, mangoes and grapes was reported to possess beneficial effects as a therapeutic and preventive agent for a range of disorders. Last 15 years have seen tremendous efforts by researchers worldwide to develop this wonderful molecule for its clinical use for the treatment of variety of disorders. These studies also provide insight into the mechanism of action of Lupeol and suggest that it is a multi-target agent with immense anti-inflammatory potential targeting key molecular pathways which involve nuclear factor kappa B (NFκB), cFLIP, Fas, Kras, phosphatidylinositol-3-kinase (PI3K)/Akt and Wnt/β-catenin in a variety of cells. It is noteworthy that Lupeol at its effective therapeutic doses exhibit no toxicity to normal cells and tissues. This mini review provides detailed account of preclinical studies conducted to determine the utility of Lupeol as a therapeutic and chemopreventive agent for the treatment of inflammation and cancer.

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Section: Chemical Structure and Analysismentioning

confidence: 99%

Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene

2009

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show abstract

“…The presence of seven methyl singlets and an olefinic function in the 1 HNMR spectrum reveals that lupeol is of pentacylic triterpenoidal type in nature. [18] Study conducted by Martelanc et al, using high-performance liquid chromatographic (HPLC) method with UV and mass spectrometry (MS), showed that lupeol exhibits a parent ion peak at m/z 409 [M + H+-18. [18] An overview of lupeol and its beneficial effects…”

Section: Chemical Structure and Analysismentioning

confidence: 99%

Biological activities of lupeol

P¹,

A²,

K³

et al. 2011

Syst Rev Pharm

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“…They have a wide geographical distribution range including Japan, China, Korea, Taiwan and Russia. Previously, it was reported that Adenophorae Radix contains triterpenoids (Du et al ., ; Yao et al ., ), phenolic glycosides (Kuang et al ., ; Koike et al ., ), sterols, alkaloids (Asano et al ., ) and essential oils (Miyazawa et al ., ). Anti‐obesity (Choi et al ., ), anti‐oxidant (Kim et al ., ; Kim et al ., ), anti‐cancer (Lee et al ., ) and anti‐bacterial (Huang, ) activities have been reported for the extract of Adenophorae Radix.…”

Section: Introductionmentioning

confidence: 99%