We investigate how large-scale tectonic forcing can influence landscape development. The combined forward and inverse modeling strategy that we exploit is known as closed-loop modeling or twin experimentation (Canet et al., 2009;Li et al., 2011;Lorenz, 1963). This approach is often employed by the seismological community and is a helpful means for objectively investigating complex systems that is based upon a combination of guided forward and inverse modeling. Here, we adopt a three-fold strategy. First, we extract a regional uplift history by inverting a revised and augmented inventory of river profiles. This approach builds upon previous work by Paul et al. (2014), Wilson et al. (2014), and Rudge et al. (2015. The recovered history is independently calibrated, and then separately tested (i.e., validated) using two different suites of geologic observations. Second, the recovered uplift history is used to force a series of dynamic landscape simulations for a sequence of increasingly complex spatio-temporal precipitation patterns. Finally, synthetic river profiles extracted from these simulated landscapes are inverted in order to gauge recoverability of the original regional uplift history. It is important to emphasize that the source of the original uplift history is not relevant-the principal issue concerns recoverability of any