Construction of an aggregation-induced electrochemiluminescent sensor based on an aminal-linked covalent organic framework for sensitive detection of glutathione in human serum

Song, Linlin; Gao, Wenqiang; Han, Qinru; Huang, Yiping; Cui, Lin; Zhang, Chunyang

doi:10.1039/d2cc03753j

Cited by 22 publications

(5 citation statements)

References 36 publications

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“…Furthermore, concerning bioremediation approaches for heavy metal pollution, aminal linked porous organic polymers were used for the simultaneous adsorption and reduction of Cr(VI) to Cr(III) 151 and selective detection of Fe 3+ ions. 152 Moving to organic molecules, covalent organic frameworks (COFs) based on aminals were successfully used in the detection of amino acids, as phenylalanine 153 and glutathione, 154 and decontamination of mustard-gas simulant. 155 Since the first synthesis of aminal-linked frameworks by Jiang et.al., 156 the versatility of aminals allows it to engage in several applications based on different aminal polymeric frameworks.…”

Section: Aminal-based Materialsmentioning

confidence: 99%

Progress on the Synthesis and Applications of Aminals: Scaffolds for Molecular Diversity

Rippel,

Ferreira,

Branco

2024

Synthesis

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Aminals, characterized by a central carbon linking two nitrogen atoms, are versatile building blocks in modern chemistry. This review addresses a literature gap by exploring the synthesis and applications of aminals, with a focus on drug discovery and molecular diversity. Beyond medicinal chemistry, aminals find applications as key components in bioactive compounds and versatile tools in materials chemistry. The review covers fundamental characteristics, synthetic methodologies, stability, and applications, emphasizing alternative synthesis methods to the well-established aldehyde-amine condensation. This inclusive exploration provides insights into diverse synthetic pathways, expanding the versatility of the aminal scaffold. 1. Introduction 2. The Aminal Group 3. Aminal Synthesis 3.1 Metal-free Approaches 3.2 Metal-catalyzed Approaches 3.3 Photoredox Methodologies 3.4 Via rearrangements 3.5 Decarboxylative Coupling 4. Aminals as Synthetic Tools 5. Synthesis of Aminal-containing Natural Products 6. Aminal-based Materials 7. Conclusions

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Section: Aminal-based Materialsmentioning

confidence: 99%

Progress on the Synthesis and Applications of Aminals: Scaffolds for Molecular Diversity

Rippel,

Ferreira,

Branco

2024

Synthesis

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“…The combination of AIE ligands and frameworks paved a potential way for better ECL sensors; that is, the large surface area and porous properties of MOFs make ECL reactions more effective while the AIE molecular motion is restricted by the rigid MOF structure, which is theoretically beneficial to AIE emission [58]. Similar to the term aggregation-induced emission, the strong ECL emission based on the restricted AIE molecules within MOFs has been named 'aggregation-induced ECL' (AIECL) [59], which is also successfully used in COFs [60] and polymers [61].…”

Section: Ecl Nanoemittersmentioning

confidence: 99%

Framework-Enhanced Electrochemiluminescence in Biosensing

Hou

et al. 2023

Chemosensors

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Electrochemiluminescence (ECL) has attracted increasing attention owing to its intrinsic advantages of high sensitivity, good stability, and low background. Considering the fact that framework nanocrystals such as metal–organic frameworks and covalent organic frameworks have accurate molecular structures, a series of framework-based ECL platforms are developed for decoding emission fundamentals. The integration of fluorescent ligands into frameworks significantly improves the ECL properties due to the arrangement of molecules and intramolecular electron transfer. Moreover, the various framework topologies can be easily functionalized with the recognition elements to trace the targets for signal readout. These ECL enhancement strategies lead to a series of sensitive analytical methods for protein biomarkers, DNA, small biomolecules, and cells. In this review, we summarize recent advances in various functions of frameworks during the ECL process, and constructions of framework-based ECL platforms for biosensing. The framework-based ECL nanoemitters and enhancement mechanisms show both theoretical innovation and potential applications in designing ECL biosensing systems. Perspectives are also discussed, which may give a guideline for researchers in the fields of ECL biosensing and reticular materials.

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“…Among various ECL systems, the development of highly effective luminophores is the key to building efficient sensing platforms. Covalent organic frameworks (COFs) are an emerging group of porous materials that are formed from building units through covalent bonds, which have been a hot issue in the ECL field because of their unique characteristics such as abundant porosity, excellent stability, and functional diversity. − In the previous work, our team integrated the 3,4,9,10-perylenetetracarboxylic acid (PTCA) in the COF structure as a luminophore with steady ECL emission (PTCA-COF), and in addition to lowering the cost, its outstanding characteristics also ensured the bioactivity of the sensor. Nevertheless, the limitations, including poor conductivity and low electron-transfer efficiency of COFs, resulted in poor signal strength of the system, limiting their further application in ECL sensors. , Consequently, significant efforts should be devoted to developing efficient signal amplification strategies to achieve high-performance ECL sensors.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Multieffect Catalytic Amplified Cathodic Electrochemiluminescence Biosensor via Target Binding-Induced Aptamer Conformational Changes for the Ultrasensitive Detection of Synthetic Cathinone

An,

Jiang,

et al. 2023

ACS Appl. Mater. Interfaces

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Construction of an aggregation-induced electrochemiluminescent sensor based on an aminal-linked covalent organic framework for sensitive detection of glutathione in human serum

Abstract: We demonstrate the construction of an aggregation-induced electrochemiluminescent (AIECL) sensor for glutathione (GSH) assay by integrating aminal-linked covalent organic framework (A-COF) with manganese dioxide (MnO2) nanosheets. The AIECL of the...

Cited by 22 publications

References 36 publications

Progress on the Synthesis and Applications of Aminals: Scaffolds for Molecular Diversity

Progress on the Synthesis and Applications of Aminals: Scaffolds for Molecular Diversity

Framework-Enhanced Electrochemiluminescence in Biosensing

Synergistic Multieffect Catalytic Amplified Cathodic Electrochemiluminescence Biosensor via Target Binding-Induced Aptamer Conformational Changes for the Ultrasensitive Detection of Synthetic Cathinone

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