RETRACTED: Construction of chitosan-based asymmetric antioxidant and anti-inflammatory repair film for acceleration of wound healing

Hu, Le; Zou, Lin; Liu, Qing; Geng, Yusheng; Xu, Gan; Chen, Li; Pan, Panpan; Chen, Jingdi

doi:10.1016/j.ijbiomac.2022.06.103

Cited by 25 publications

(7 citation statements)

References 34 publications

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“…7 Antibiotic-containing hydrophilic degradable microbeads prevent wound infection and accelerate wound healing through spontaneous drug release in early care treatment. 43 In addition, the nanofiber surface and internal geometry (fiber diameter and membrane porosity) have been found to significantly affect the efficiency of the membrane in terms of water wettability and absorbency. 44 Figure 6 reveals the captured dynamic images of contact angles at different time points.…”

Section: Resultsmentioning

confidence: 99%

“…Many factors contribute to chronic wounds, including age, ischemia, and infection. 43 All wounds eventually host bacteria, typically within 48 h of contamination, although the point at which bacteria negatively impacts wound healing remains controversial. Incorporating some antimicrobial activity into wound dressings is an appropriate strategy to prevent initial infection.…”

Section: Resultsmentioning

confidence: 99%

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Characterization of electrospun fibers and electrospray vancomycin-containing beads through the interstitial or lamellar separation of bead composite fiber membranes to evaluate their biomedical application in vitro

Liu

Chen

Huang

et al. 2022

Journal of Industrial Textiles

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Considering the advantages of electrospun thermoplastic polyurethane (TPU)-fibers and antibiotic (vancomycin)-containing polyvinyl alcohol (PVA)-microbeads for wound dressings, a composite membrane was developed. Electrospun-aligned TPU-fibers were collected using a high-speed drum collector. Three groups of TPU-only, double-sided PVA-microbeads composite TPU-fibers (PVA/TPU/PVA sandwich, DSV40), and simultaneous electrospray PVA-microbeads/electrospun TPU-fibers (interstitial PVA-microbeads, CV40) composite membranes were prepared and characterized. The composites were tested for morphology, infrared spectroscopy, and tensile tests along the fiber-parallel (MD) and fiber-perpendicular (CD) directions, water wettability and absorption, antibacterial activity, and biocompatibility. The results showed that the tensile strength, modulus, and strain of TPU-only in MD and CD directions were 7.31 ± 1.13 and 2.47 ± 0.43 MPa, 2.73 ± 0.36 and 0.69 ± 0.07 MPa and 285.02 ± 23.56 and 360.70 ± 34.01%, respectively. Moreover, MD-direction tensile properties of DSV40 and CV40 resulted in a significant increase in strength (9.05 ± 2.19 and 9.77 ± 1.51 MPa) and modulus (10.97 ± 1.65 and 5.47 ± 0.94 MPa), but a decrease in strain (92.42 ± 11.68 and 185.78 ± 24.85%), compared to TPU-only. However, DSV40 and CV40 showed opposite trends (respective strength of 0.99 ± 0.07 and 2.11 ± 0.33 MPa, modulus of 0.21 ± 0.01 and 0.48 ± 0.51 MPa, and strain of 460.69 ± 29.38 and 435.92 ± 29.26%) in the CD direction compared to TPU-only. In terms of wettability after 10 s observation, DSV40 obtained a hydrophilic tendency (25.91°) than CV40 (74.22°) and TPU-only (121.06°). The results of antibacterial activity showed that both DSV40 and CV40 had good antibacterial effects on Staphylococcus aureus but the inhibitory effect on Escherichia coli was poor. The biocompatibility test confirmed that neither DSV40 nor CV40 negatively affected L929 cell viability.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Characterization of electrospun fibers and electrospray vancomycin-containing beads through the interstitial or lamellar separation of bead composite fiber membranes to evaluate their biomedical application in vitro

Liu

Chen

Huang

et al. 2022

Journal of Industrial Textiles

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“…For accelerating wound healing, several strategies have been developed and one of them consists in the utilization of antioxidants, since around the moist microenvironment of the wound occurs oxidative stress. With this purpose, Hu et al [ 138 ] constructed a chitosan-based bioinspired asymmetric wound repair composite film, constituted by two different functional layers: a hydrophilic chitosan/silk fibroin repair layer, and a hydrophobic bacteriostatic TTO layer with a rough surface. At the same time, sodium ascorbate—entrapped poly (lactic- co -glycolic acid) microspheres were distributed homogeneously in the hydrophilic layer.…”

Section: Antioxidant Properties Of Ttomentioning

confidence: 99%

“…The results showed that this film exhibited excellent biocompatibility, and good antibacterial capacity, enhancing not only the adhesion and proliferation of the fibroblast cell line that was isolated from a mouse NIH/Swiss embryo (NIH3T3) cell in vitro but also facilitating the healing of a rat full-thickness skin wounds model. Simultaneously, it was observed, through the DPPH method, that the film presented antioxidant activity after incubation for 12 h, which was ascribed to the release of sodium ascorbate and TTO [ 138 ]. According to the authors, this asymmetric film could be of great importance in wound healing and related soft tissue regeneration.…”

Section: Antioxidant Properties Of Ttomentioning

confidence: 99%

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

et al. 2023

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Acne vulgaris is an inflammatory dermatological pathology that affects mostly young people. However, it can also appear in adulthood, mainly in women. It has a high psychosocial impact, not only at the time of active lesions but also due to the consequences of lesions such as scarring and hyperpigmentation. Several factors are involved in the physiopathology of acne and the constant search for active ingredients is a reality, namely phytotherapeutic ingredients. Tea tree oil is an essential oil extracted from Melaleuca alternifolia (Maiden & Betch) Cheel with known antibacterial, anti-inflammatory, and antioxidant properties, making it a candidate for the treatment of acne. This review aims to describe the various properties of tea tree oil that make it a possible ingredient to use in the treatment of acne and to present several human studies that have evaluated the efficacy and safety of using tea tree oil in the treatment of acne. It can be concluded that tea tree oil has good antibacterial, anti-inflammatory, and antioxidant properties that result in a decrease in the number of inflammatory lesions, mainly papules, and pustules. However, given the diversity of study designs, it is not possible to draw concrete conclusions on the efficacy and safety of this oil in the treatment of acne.

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“…Meanwhile, research found that three terpenic compounds α-terpinene, α-terpinolene, and γ-terpinene in TTO endowed it with strong antioxidant performance [21]. Therefore, TTO has been introduced in various polymer films or nanofibers such as chitosan [23], polylactic acid [24], poly(ethylene oxide) [25], and polyurethane [20] for functionalization. Recently, Hu and co-authors fabricated several asymmetric chitosan films with a hydrophilic chitosan/silk fibroin repair layer and hydrophobic composite layers using the solution casting method [23].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of Asymmetric Polyvinyl Pyrroli-Done/Polycaprolactone Composite Nanofiber Loaded with Tea Tree Extract

Xie

Hou

et al. 2022

Polymers

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To develop a novel asymmetric nanofiber membrane with antioxidant and antibacterial activities, biocompatible polyvinyl pyrrolidone (PVP) and polycaprolactone (PCL) were used as carriers to load water-soluble tea tree extract (TTE) and hydrophobic tea tree oil (TTO) via electrospinning and electrostatic spraying, respectively, which was named as TTE-PVP-3/TTO-PCL. The results show that uniform TTE-PVP nanofibers with an average diameter of 95 ± 27 nm could be obtained when the mass ratio of TTE to PVP was set as 1:3. Homogeneous TTO/PCL microspheres with an average size of 4.38 ± 0.79 µm could be obtained when the propulsion speed was 0.08 mm/min and the voltage was 10 KV. The activity study showed that TTE could only improve the antioxidant activity of TTE-PVP-3/TTO-PCL, while TTO could improve the antibacterial activity effectively. Under experimental conditions, the inhibition zones of TTE-PVP-3/TTO-PCL against Staphylococcus aureus and Escherichia coli were 7.50 ± 0.48 mm and 9.55 ± 0.45 mm, respectively, and its scavenging rates for 2,2-diphenylpicrylhydrazyl (DHPP) and hydroxyl radical were 59.79 ± 4.10% and 61.02 ± 4.95%, respectively. In conclusions, TTE-PVP-3/TTO PCL can be potentially used as a new kind of anti-oxidative and antibacterial wound dressings.

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RETRACTED: Construction of chitosan-based asymmetric antioxidant and anti-inflammatory repair film for acceleration of wound healing

Cited by 25 publications

References 34 publications

Characterization of electrospun fibers and electrospray vancomycin-containing beads through the interstitial or lamellar separation of bead composite fiber membranes to evaluate their biomedical application in vitro

Characterization of electrospun fibers and electrospray vancomycin-containing beads through the interstitial or lamellar separation of bead composite fiber membranes to evaluate their biomedical application in vitro

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

Preparation and Properties of Asymmetric Polyvinyl Pyrroli-Done/Polycaprolactone Composite Nanofiber Loaded with Tea Tree Extract

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