Consumo de frutose e exercício físico, impacto na síndrome metabólica.

Botezelli, José Diego; Moura, Rodrigo Ferreira de; Rossi, Caroline de Almeida; Dalia, Rodrigo Augusto; Cambri, Lucieli Teresa; Mello, María Alice Rostom de

doi:10.5016/1980-6574.2010v16n1p231

Cited by 3 publications

(4 citation statements)

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“…The increased oxidative stress generates an inflammatory process that in long-term, culminates in the hepatocyte apoptosis and liver necrosis which corroborates with the results of this experiment, such as hypertrophy of hepatocytes, Kupffer cells, sinusoids and hepatic increase (BASCIANO, FEDERICO and ADELI, 2005;BOTEZELLI, MOURA, ROSSI et al, 2010).…”

Section: Discussionsupporting

confidence: 90%

Effects of aerobic exercise of different intensities in the liver of metabolic syndrome animals

et al. 2016

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Introduction: Metabolic syndrome (MS) corresponds to a sum of alteration in which, glucose intolerance is characterized as one of the most important. Among these are included: insulin resistance, type 2 diabetes mellitus, hypertension, obesity, dyslipidemia, endothelial dysfunction and others Nonalcoholic steatohepatitis (NASH) is also currently cited as a risk factor for MS Studies have demonstrated a strong correlation between physical inactivity and MS. The aim of this paper was to evaluate the effects of aerobic exercise training of different intensities on the liver of metabolic syndrome rats. Methods: 20 male Wistar rats were used and divided into four groups (n=5): control (C) sedentary MS (MS), walking MS (WMS) and running MS (RMS). Fructose-drinking rats received D-fructose (100 g/l). MS Training rats were assigned to a treadmill training protocol at low and moderate intensity during 1 h/day, 5 days/week for 8 weeks. At the end of the experiment, the livers were collected and submitted to a histological technique (HE). The images were captured and morphometric and stereological analysis of the hepatic tissue were performed. Results: It was verified that MS promoted a hypertrophy of the hepatocytes, a significant increase in the density volume of the hepatocytes, of the Kupffer cells, and hepatic sinusoids, and that, in both intensities (Running and Walking) the exercise training has mitigated the alterations. Conclusions: The data suggest, as nonpharmacological treatment, the walking (low intensity) is the most efficient, able to reverse the alterations caused by metabolic syndrome, the results being approximate to those of control group.

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Section: Discussionsupporting

confidence: 90%

Effects of aerobic exercise of different intensities in the liver of metabolic syndrome animals

et al. 2016

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“…Sin embargo, el resto de la evidencia al respecto está limitada a ensayos no controlados y algunos otros estudios en población adolescente. A pesar de ello, los estudios de intervención descritos (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37) sugieren que la restricción de fructosa a corto plazo reduce la LDN y la grasa hepática.…”

Section: Discussionunclassified

“…La alta cantidad de fibra que aporta la dieta mediterránea, acompañada de polifenoles, antioxidantes, fitoquímicos y metabolitos vegetales demostraron ser capaces de inhibir la LDN, la esteatosis hepática y la inflamación. Sobre la base de estos efectos positivos que promueven la salud, queda claro que cambiar a una dieta mediterránea es una estrategia terapéutica eficaz para mejorar el resultado o la gravedad de la enfermedad por HGNA (28,29) .…”

Section: Patogénesisunclassified

Hígado graso no alcohólico y consumo de fructosa: revisión y actualización de la evidencia

Alcoba

Crespi

2023

rncm

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El hígado graso no alcohólico (HGNA) es actualmente una de las principales causas de enfermedad hepática crónica. Se define como la presencia de esteatosis en ausencia de otras causas de enfermedad hepática crónica y su prevalencia aumenta en todo el mundo. Se ha sugerido que existe una relación causal entre el aumento de la prevalencia de HGNA y la ingesta de edulcorantes nutritivos, en particular de fructosa. El objetivo general de esta revisión es describir la asociación entre el hígado graso no alcohólico y la fructosa en humanos. Se realizó una búsqueda de artículos científicos con palabras clave. Los resultados de esta revisión describen que el consumo de fructosa se ha incrementado en las últimas décadas, principalmente a partir de la ingesta de sacarosa y jarabe de maíz de alta fructosa (JMAF), edulcorante de uso común en la industria alimentaria. El consumo crónico de fructosa promueve una serie de mecanismos que aumentan la lipogénesis hepática. Esta tasa de síntesis supera la tasa catabólica de oxidación de ácidos grasos y la capacidad de exportación como VLDL, que contribuye de manera importante a los lípidos intrahepáticos en el HGNA. El manejo inicial del HGNA implica, principalmente, recomendaciones de alimentación como disminución del consumo de azúcares libres, patrón de dieta mediterránea y cambios del estilo de vida para lograr la pérdida de peso; sin embargo, la evidencia es limitada y se necesitan grandes estudios prospectivos y ensayos controlados que evalúen la relación entre la fructosa y el HGNA.

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“…It was previously demonstrated that physical exercise improves glucose tolerance and reduces insulin resistance in animals fed a fructose-rich diet (BOTEZELLI et al, 2016). However, few studies involving MS utilized physical training with intensity and duration controlled, increasing the doubts about if the physical training exerts prophylactic, therapeutic or both actions in relation to MS (BOTEZELLI et al, 2009). Thus, the present research aims to evaluate the effects of Physical Training in intensity at AnT (determined by the Maximal Lactate Steady State test) in two different periods, early and late in rats fed with fructose-rich diet, on important components of the MS.…”

Section: Introductionmentioning

confidence: 99%

Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet

Gaspar¹,

Kuga²,

Muñoz³

et al. 2018

Biosci. J.

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ABSTRACT:This study aims to examine the effects of physical training performed in early (preventive) or late (therapeutic) protocols on body weight gain, glucose tolerance, and triglycerides accumulation in rats fed on a fructoserich diet. Wistar rats were allocated into two major groups according to the diet received: Control (C-standard diet) and Fructose (F-diet containing 60% fructose) fed during 120 days. Next, these two groups were distributed into six groups: C and F that were kept inactive; CTE (Control Trained Early) and FTE (Fructose Trained Early) that were submitted to Anaerobic Threshold (AnT) training from 28 to 120 days; CTL (Control Trained Late) and FTL (Fructose Trained Late) trained from 90 to 120 days. Physical Training was composed by swimming (5 days/week) at AnT determined by maximum lactate stead state (MLSS). The Oral Glucose Tolerance Test (oGTT) was performed 48h after the last in vivo analysis and did not showed differences between the groups. After, the animals were euthanized for heart, liver, and adipose tissue extraction. The early exercised animals had lower body weight compared to their sedentary littermates. Also, the fructose-rich diet increased liver lipids content in the sedentary animals and physical training successfully reduced this parameter in both major groups. These results suggests that physical training at the AnT performed in early or late protocols are effective to prevent and treat metabolic disorders related to fructose intake.

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Consumo de frutose e exercício físico, impacto na síndrome metabólica.

Cited by 3 publications

References 48 publications

Effects of aerobic exercise of different intensities in the liver of metabolic syndrome animals

Effects of aerobic exercise of different intensities in the liver of metabolic syndrome animals

Hígado graso no alcohólico y consumo de fructosa: revisión y actualización de la evidencia

Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet

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