“…We have shown that hydrogen suppresses signaling pathways in allergies [ 26 ] and inflammation [ 27 ] without directly scavenging reactive oxygen/nitrogen species. Signaling molecules that are modulated by hydrogen include Lyn [ 26 , 28 ], Ras [ 29 ], MEK [ 29 , 30 ], ERK [ 12 , 24 , 29 – 37 ], p38 [ 12 , 16 , 24 , 27 , 30 , 32 , 33 , 35 – 41 ], JNK [ 13 , 24 , 27 , 30 , 32 , 33 , 35 – 38 , 40 , 42 – 47 ], ASK1 [ 27 , 46 ], Akt [ 12 , 29 , 36 , 37 , 48 , 49 ], GTP-Rac1 [ 36 ], iNOS [ 27 , 34 , 36 , 50 – 52 ], Nox1 [ 36 ], NF-κB p65 or NF-κB [ 12 , 14 , 27 , 35 – 38 , 40 , 41 , 43 , 49 , 53 – 75 ], IκBα [ 27 , 40 , 41 , 54 , 60 , 62 , 69 , 73 , 76 ], ST...…”