Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression

Li, Shaowei; Fujino, Masayuki; Ichimaru, Naotsugu; Kurokawa, Ryōsuke; Hirano, Shin‐ichi; Mou, Lisha; Takahara, Shiro; Takahara, Taro; Li, Xiaokang

doi:10.1038/s41598-018-32411-4

Cited by 34 publications

(25 citation statements)

References 45 publications

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“…Similar results were demonstrated by Zhang and colleagues in experiments on the proliferation and migration of vascular smooth muscle cells 15. Han et al showed that sirtuin (SIRT)1 is highly expressed in brain metastasis,16 and several scholars have demonstrated that hydrogen can suppress SIRT1 signaling in different models 17–19. Those studies suggest that hydrogen gas has a unique therapeutic effect on the brain metastasis of NSCLC.…”

Section: Discussionsupporting

confidence: 70%

<p>Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report</p>

Chen¹,

Mu²,

Lu³

et al. 2019

OTT

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Lung cancer is the most common type of tumor, prone to contralateral lung, bone and brain metastasis. We report a 44-year-old woman diagnosed with lung cancer with multiple metastases in November 2015. Oral targeted drugs were initiated after the removal of brain metastases, and most lesions remained stable for 28 months. In March 2018, intracranial multiple metastases, as well as hydrocephalus accumulation in the third ventricle and lateral ventricles, and metastases in bone, adrenal gland, liver were noted. Hydrogen-gas monotherapy was started to control the tumor a month later. After 4 months, the size of multiple brain tumors was reduced significantly, and the amount of hydrocephalus in the third ventricle and lateral ventricles reduced significantly. After 1 year, all brain tumors had disappeared, and there were no significant changes in metastases in the liver and lung. These data show that, after standard treatments had failed, hydrogen-gas monotherapy elicited significant effective control of tumors (especially those in the brain), and survival time was lengthened.

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Section: Discussionsupporting

confidence: 70%

<p>Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report</p>

Chen¹,

Mu²,

Lu³

et al. 2019

OTT

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“…Hydrogen is a novel antioxidant that has aroused wide attention in recent years. A great number of studies have demonstrated that hydrogen may protect tissues via multiple mechanisms (Li et al, 2018;Meng et al, 2016;Nishimaki et al, 2018;Niu et al, 2020;Ohta, 2014). Of these mechanisms, the anti-inflammatory effect of hydrogen is noteworthy.…”

Section: Discussionmentioning

confidence: 99%

Effects of changes on gut microbiota in children with acute Kawasaki disease

Shen¹,

Ding²,

Yang³

et al. 2020

PeerJ

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Background Kawasaki disease (KD) is an acute febrile illness of early childhood. The exact etiology of the disease remains unknown. At present, research on KD is mostly limited to susceptibility genes, infections, and immunity. However, research on the correlation between gut microbiota and KD is rare. Methods Children with a diagnosis of acute KD and children undergoing physical examination during the same period were included. At the time of admission, the subjects’ peripheral venous blood and feces were collected. Faecal samples were analyzed for bacterial taxonomic content via high-throughput sequencing. The abundance, diversity, composition, and characteristic differences of the gut microbiota in KD and healthy children were compared by alpha diversity, beta diversity, linear discriminant analysis and LDA effect size analysis. Blood samples were used for routine blood examination, biochemical analysis, and immunoglobulin quantitative detection. Results Compared with the control group, the community richness and structure of gut microbiota in the KD group was significantly reduced (Chao1 richness estimator, mean 215.85 in KD vs. mean 725.76 in control, p < 0.01; Shannon diversity index, mean 3.32 in KD vs. mean 5.69 in control, p < 0.05). LEfSe analysis identified two strains of bacteria significantly associated with KD: Bacteroidetes and Dorea. Bacteroidetes were enriched in healthy children (mean 0.16 in KD vs. mean 0.34 in control, p < 0.05). Dorea was also enriched in healthy children but rarely existed in children with KD (mean 0.002 in KD vs. mean 0.016 in control, p < 0.05). Compared with the control, IgA and IgG in the KD group decreased (IgA, median 0.68 g/L in KD vs. median 1.06 g/L in control, p < 0.001; IgG, median 6.67 g/L in KD vs. median 9.71 g/L in control, p < 0.001), and IgE and IgM levels were not significantly changed. Conclusions Dysbiosis of gut microbiota occurs in children with acute KD and may be related to the etiology or pathogenesis of KD. It is worth noting that for the first time, we found that Dorea, a hydrogen-producing bacterium, was significantly reduced in children with acute KD. Overall, our results provide a theoretical basis for the prevention or diagnosis of KD based on intestinal microecology.

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“…This approach can significantly protect liver grafts from IRI [ 104 ], providing a potentially effective strategy for organ preservation. Other studies demonstrated the protective effects of H 2 in liver damage induced by parasites [ 105 ], obstructive jaundice [ 106 ], shock and resuscitation [ 107 ], sepsis [ 108 ], doxorubicin [ 6 ], and aflatoxin B1 [ 109 ]. In a mouse model of nonalcoholic fatty liver disease (NAFLD), HW downregulated Nrf2-mediated miR-136 expression by targeting the maternally expressed 3 long noncoding RNA gene [ 110 ], providing a rationale for further clinical trials.…”

Section: Preventive and Therapeutic Applications Of H 2 mentioning

confidence: 99%

Hydrogen: A Novel Option in Human Disease Treatment

Yang

Dong

et al. 2020

Oxidative Medicine and Cellular Longevity

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H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The potential mechanisms underlying the action of H2 gas are not clear. H2 gas may regulate the anti-inflammatory and antioxidant activity, mitochondrial energy metabolism, endoplasmic reticulum stress, the immune system, and cell death (apoptosis, autophagy, pyroptosis, ferroptosis, and circadian clock, among others) and has therapeutic potential for many systemic diseases. This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases.

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Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression

Cited by 34 publications

References 45 publications

<p>Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report</p>

<p>Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report</p>

Effects of changes on gut microbiota in children with acute Kawasaki disease

Hydrogen: A Novel Option in Human Disease Treatment

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