Consumption ofCoprinus comatuspolysaccharide extract causes recovery of alcoholic liver damage in rats

Abstract

Context: Excess use of alcohol is known to be associated with liver diseases such as fatty liver, alcoholic hepatitis, and cirrhosis. Various practices may be applied to prevent or treat the damage caused by chronic alcoholism. Coprinus comatus (O.F. Mü ll.) Pers. (Agaricaceae) is a macrofungus that has been reported to aid the recovery of murine livers damaged by benzopyrene. Objective: In this study, the possible therapeutic effects of three different doses (50, 100, and 150 mg/kg) of C. comatus polysaccharide (PS) extract were studied in rats subjected to an alcoholic diet. The histological and biochemical results were compared between the control and experimental groups. Materials and methods: Modified Lieber-Decarli's calorie-adjusted liquid alcohol diet was given orally for 60 d. In addition to histopathology, alanine transaminase (ALT), aspartate transaminase (AST), mitochondrial membrane integrity, total cytochrome-c oxidase activity (TotalStCox), total mitochondrial cytochrome-c oxidase activity (TotalMtStCox), and caspase-3 values were used as liver parameters, and liver sections from all experimental groups were examined by electron microscopy. Results: Using histopathological assessment, it was observed that there was a decline in liver hepatocyte vacuolization in the treatment group fed 50 mg PS/kg. The TotalStCox and TotalMtStCox values of this group differed from the EtOH control group (p50.05). Discussion and conclusion: Daily administration of 50 mg/kg of C. comatus PS extract considerably reduced the negative effects of alcohol on liver structure and function.

Include mushroom in daily diet—A strategy for better hepatic health

“…Seven day treatment with aqueous A c c e p t e d M a n u s c r i p t 13 peroxidation intensity in a statistically significant manner and also showed prevention of histological changes in liver cross sections (91) . A recent study of Ozalp et al, (2014) has shown that daily administration of 50 mg/kg of C. comatus polysaccharides extract considerably reduced the negative effects of alcohol on rat liver (92) .…”

The antioxidant activities of alkalic-extractable polysaccharides from Coprinus comatus on alcohol-induced liver injury in mice

“…investigated the hypoglycaemic, hypolipidaemic, and antioxidant activities of mycelia selenium-polysaccharides and the hepatoprotective activities of fruiting body polysaccharides from C . comatus , respectively 14 , 15 . However, previous research on C .…”

Mycelium Polysaccharides from Termitomyces albuminosus Attenuate CCl4-Induced Chronic Liver Injury Via Inhibiting TGFβ1/Smad3 and NF-κB Signal Pathways

“…The fruiting bodies of T. albuminosus are composed of bioactive components, such as polysaccharides, proteins, amino acids, lipids, ergosterol, saponins, cerebrosides, hydrogen peroxide-dependent phenol oxidase, alkaline protease, coumarin and melanin, which are used to strengthen peristaltic ability and in the treatment of some diseases, including intestinal carcinoma, hemorrhoids, hyperlipidemia, hyperglycemia, and antioxidant and antimicrobial diseases [10,11,12,13,14,15,16]. Among these bioactive components, polysaccharides have attracted increasing attention due to their antioxidant, immunomodulating, hepatoprotective, and anti-inflammatory biological activities [11,17,18]. Because the T. albuminosus fruiting body cannot be artificially cultivated, T. albuminosus mycelia are easily obtained by submerged fermentation, which is a rapid and alternative method.…”