Contact and contactless diffuse reflectance spectroscopy: potential for recovery monitoring of vascular lesions after intense pulsed light treatment

Kuzmina, Ilona; Diebele, Ilze; Spīgulis, Jānis; Valeine, Lauma; Berzina, Anna; Abelite, Anita

doi:10.1117/1.3569119

Cited by 18 publications

(14 citation statements)

References 11 publications

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“…Using double-pulse narrowband IPL irradiation, our data do not demonstrate a clear relationship between increasing irradiance and persistant vascular shutdown. This observation is consistent with other studies [13,28,29] in which a similar effect was observed of improved treatment outcome with an increasing number of pulses. One key difference between these studies and our present study is that they involved use of mulitple treatment sessions of multiple pulses, compared to our single use of double pulse narrowband IPL.…”

Section: Discussionsupporting

confidence: 93%

Targeted narrowband intense pulsed light on cutaneous vasculature

et al. 2015

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Background and Objectives Laser based therapies are the standard treatment protocol for port wine stain in the United States, but complete removal is infrequently achieved. Intense pulsed light (IPL) offers a broadband light spectrum approach as a viable treatment alternative. Previous studies suggest that IPL can be more effective in treatment of port wine stain by utilizing multiple wavelengths to selectively target different peaks in oxy- and deoxy-hemoglobin. Our study objectives were to (i) determine a characteristic radiant exposure able to achieve persistent vascular shutdown with narrowband IPL irradiation, (ii) determine the degree to which narrowband IPL irradiation can achieve persistent vascular shutdown, and (iii) compare the effectiveness of narrowband IPL radiation to single wavelength pulsed dye laser (PDL) irradiation in achieving persistent vascular shutdown. Study Design/Materials and Methods We utlized either single pulse or double, stacked pulses in narrowband IPL experiments, with the IPL operating over a 500–600 nm wavelength range on the rodent dorsal window chamber model. We compared the results from our narrowband IPL experiments to acquired PDL data from a previous study and determined that narrowband IPL treatments can also produce persistent vascular shutdown. We ran Monte Carlo simulations to investigate the relationship between absorbed energy, wavelength, and penetration depth. Results For single and double pulse narrowband IPL irradiation we observed (i) little to no change in blood flow, resulting in no persistent vascular shutdown, (ii) marked acute disruption in blood flow and vascular structure, followed by partial to full recovery of blood flow, also resulting in no persistent vascular shutdown, and (iii) immediate changes in blood flow and vascular structure, resulting in prolonged and complete vascular shutdown. Monte Carlo modeling resulted in a 53.2% and 69.0% higher absorbed energy distribution in the top half and the total simulated vessel when comparing the composite narrowband IPL to the 595 nm (PDL), respectively. Conclusions Our data collectively demonstrate the potential to achieve removal of vascular lesions using a 500–600 nm range. Additionally, the narrowband IPL was tuned to optimize a specific wavelength range that can be used to treat PWS, whereas the PDL can only operate at one discrete wavelength. Lasers Surg. Med.

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Section: Discussionsupporting

confidence: 93%

Targeted narrowband intense pulsed light on cutaneous vasculature

et al. 2015

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“…vascular parameters of a PWS lesion. The stronger absorption peaks at 542 and 577 nm indicate the presence of oxyhemoglobin where the reflectance is reduced, which is consistent with the findings reported in several previous studies [14,19,20]. As discussed previously, one of the main concerns addressed with DRS measurement is that there is a limited range of μ a and s µ′ values that can be accurately determined from the reflectance measurements for a given S-D distance.…”

Section: Monitoring Blood Volume Fraction and Oxygen Saturation Durinsupporting

confidence: 86%

“…Spectrophotometers for the clinical assessment of PWS lesion were reviewed by Lister et al [18] suggesting that the cheaper, simpler and reliable devices may better suit the needs of clinical applications. Recently, Kuzmina et al [19] confirmed the potential of DRS for intense pulsed light therapy efficiency assessment of PWS lesions by the determination of optical density that derived from DRS and multispectral imaging, respectively. The feasibility Brought to you by | New York University Bobst Library Technical Services Authenticated Download Date | 7/4/15 4:33 AM to quantify and monitor the vascular parameters of PWS lesions in patients by using DRS before and during V-PDT has not been reported previously.…”

Section: Introductionmentioning

confidence: 88%

Monitoring blood volume fraction and oxygen saturation in port-wine stains during vascular targeted photodynamic therapy with diffuse reflectance spectroscopy: Results of a preliminary case study

Qiu

Chen

Wang

et al. 2014

Photonics &Amp; Lasers in Medicine

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Objective: Monitoring dynamic changes during vascular targeted photodynamic therapy (V-PDT) for port-wine stains (PWS) is crucial for achieving an optimal therapeutic outcome. The present investigation is a preliminary research study designed to quantify and monitor the vascular parameters, e.g., blood volume fraction (BVF) and oxygen saturation (StO 2 ), of a PWS lesion by using diffuse reflectance spectroscopy (DRS) before and during V-PDT. Material and methods: A portable DRS detection system was developed with an appropriate source-detector distance of 520 μm for fiber-optic probe. The diffuse reflectance spectra from 450 to 800 nm in specific regions of interest (ROIs) within a PWS lesion were recorded before and 3, 5, 10, 15, and 20 min during V-PDT. In order to extract the optical properties and vascular parameters of the PWS lesion, a modified well-known diffusion theory model with a correction factor for the vessel package effect was employed to analyze the steady state-diffuse reflectance spectra. Results: The corrected reflectance spectra of the PWS lesion can be fitted very well with the modified diffusion theory model. Differences in pretreatment values of BVF and StO 2 as well as changes in these parameters were observed between two ROIs during V-PDT. Conclusion: The ability of using DRS for quantifying and monitoring the BVF and StO 2 of a PWS lesion has been assessed. The preliminary data suggest that the clinical V-PDT efficiency is affected by the heterogeneity of the PWS lesion. DRS may have the potential to characterize the PWS lesion and to monitor V-PDT response. ZusammenfassungZiel: Die Überwachung dynamischer Veränderungen wäh-rend der gezielt-vaskulären photodynamischen Therapie (vascular targeted photodynamic therapy, V-PDT) von Feuermalen ist für das Erreichen eines optimalen Therapieerfolgs von entscheidender Bedeutung. Die vorliegende Untersuchung ist eine vorläufige Forschungsstudie zur Quantifizierung und Überwachung von Gefäßparame-tern, wie z. B. Blutvolumenanteil (BVF) und Sauerstoffsät-tigung (StO 2 ), mittels diffuser Reflexionsspektroskopie (DRS) vor und während der V-PDT von Feuermalen. Material und Methoden: Es wurde ein tragbares DRSMesssystem mit faseroptischer Sonde und geeignetem Quelle-Detektor-Abstand von 520 μm entwickelt. Im Wellenlängenbereich von 450 bis 800 nm wurden für spezifische Bereiche (regions of interest, ROIs) innerhalb eines Feuermals diffuse Reflexionsspektren vor sowie 3, 5, 10, 15 und 20 min während der V-PDT aufgezeichnet. Um die stationären diffusen Reflexionsspektren zu analysieren und daraus die optischen Eigenschaften und Gefäß-parameter des untersuchten Feuermals extrahieren zu Brought to you by | New York University Bobst Library Technical Services Authenticated Download Date | 7/4/15 4:33 AM 274 Z. Qiu et al.: Monitoring V-PDT for port-wine stains with DRS können, wurde das bekannte Diffusionstheoriemodell mit einem Korrekturfaktor für den Gefäßüberlagerungseffekt modifiziert. Ergebnisse: Die korrigierten Reflexionsspektren des untersuchten Fe...

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“…Methods such as optical Doppler tomography (ODT) 4, laser Doppler flowmetry imaging (LDFI) 5, and laser speckle imaging (LSI) measure tissue perfusion 6. Other methods such as reflectance spectroscopy 7 and cross‐polarized diffuse reflectance imaging 8 measure intrinsic absorption in tissue. All of the aforementioned methods attempt to determine PWS blood vessel depth, size, flow, and distribution in human skin before and after laser exposure.…”

Section: Introductionmentioning

confidence: 99%

Spatial frequency domain imaging of port wine stain biochemical composition in response to laser therapy: A pilot study

et al. 2012

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Background and Objective Objective methods to assess port wine stain (PWS) response to laser treatment have been the subject of various research efforts for several years. Herein, we present a pilot study using a newly developed, light emitting diode (LED) based spatial frequency domain imaging (SFDI) device to record quantitatively biochemical compositional changes in PWS after laser therapy. Study Design/Patients and Methods A SFDI system was used to image before, and after, five PWS treatment sessions [n = 4 subjects (one subject was imaged before and after two consecutive laser treatments)]. SFDI derived wide-field optical properties (absorption and scattering) and tissue chromophore concentrations including oxy-hemoglobin (ctO2Hb), deoxy-hemoglobin (ctHHb), total hemoglobin (ctTHb), and tissue oxygen saturation (stO2) are presented for skin imaged prior to and immediately after laser treatment. The SFDI derived images were analyzed by comparing the above measurements in PWS to those of normal skin and tracking changes immediately after laser exposure. Results Elevated oxy-hemoglobin (>20%) and tissue oxygen saturation (>5%) were measured in all PWS lesions and compared to values for normal skin prior to treatment. Laser treatment resulted in an increase in deoxy-hemoglobin (>100%), decrease in tissue oxygen saturation (>10%), and reduced scattering (>15%) in all PWS lesions. One subject was followed before and after two consecutive laser treatments and the overall improvement in PWS lesion blanching was quantitatively assessed by measuring a 45% decrease in dermal blood volume. Conclusion SFDI is a rapid non-contact wide-field optical technique that shows potential as an imaging device that can be used to quantify biochemical compositional changes in PWS after laser therapy. Future work will investigate the potential of SFDI to provide intra-operative guidance for laser therapy of PWS lesions on an individual patient basis.

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Contact and contactless diffuse reflectance spectroscopy: potential for recovery monitoring of vascular lesions after intense pulsed light treatment

Cited by 18 publications

References 11 publications

Targeted narrowband intense pulsed light on cutaneous vasculature

Targeted narrowband intense pulsed light on cutaneous vasculature

Monitoring blood volume fraction and oxygen saturation in port-wine stains during vascular targeted photodynamic therapy with diffuse reflectance spectroscopy: Results of a preliminary case study

Spatial frequency domain imaging of port wine stain biochemical composition in response to laser therapy: A pilot study

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