Contactless NMR Spectroscopy on a Chip

Ryan, Herbert; Song, Suk‐Heung; Zaß, Anja; Korvink, Jan G.; Utz, Marcel

doi:10.1021/ac300204z

Cited by 53 publications

(56 citation statements)

References 38 publications

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“…37 Ryan et al 8 have demonstrated microfluidic high-resolution NMR spectroscopy (see Fig. 4) using self-resonant, inductively coupled planar micro-coils, 74 which were fabricated from Cu-laminated polyimide sheets.…”

Section: Planar Spiral M-coilsmentioning

confidence: 99%

Microscale nuclear magnetic resonance: a tool for soft matter research

et al. 2012

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Nuclear magnetic resonance spectroscopy (NMR) and imaging (MRI) are important non-destructive investigative techniques for soft matter research. Continuous advancements have not only lead to more sensitive detection, and new applications, but have also enabled the shrinking of the detectable volume of sample, and a reduction in time needed to acquire a spectrum or image. At the same time, advances in microstructuring and on-chip laboratories have also continued unabated. In recent years these two broad areas have been productively joined into what we term micro nuclear magnetic resonance (mMR), an exciting development that includes miniaturized detectors and hyphenation with other laboratory techniques, for it opens up a range of new possibilities for the soft matter scientist. In this paper we review the available miniaturization technologies for NMR and MRI detection, and also suggest a way to compare the performance of the detectors. The paper also takes a close look at chiplaboratory augmented mMR, and applications within the broad soft matter area. The review aims to contribute to a better understanding of both the scientific potential and the actual limits of mMR tools in the various interdisciplinary soft matter research fields.

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Section: Planar Spiral M-coilsmentioning

confidence: 99%

Microscale nuclear magnetic resonance: a tool for soft matter research

et al. 2012

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“…A variety of planar micro-NMR detector geometries that are compatible with microfluidic devices have been proposed [5,6], including planar spiral coils [7,8], micro-slots [9], Helmholtz pairs [10], and phased array detectors [11,12].…”

Section: Introductionmentioning

confidence: 99%

An optimised detector for in-situ high-resolution NMR in microfluidic devices

Finch

Yılmaz

Utz

2016

Journal of Magnetic Resonance

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109

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Integration of high-resolution nuclear magnetic resonance (NMR) spectroscopy with microfluidic lab-on-a-chip devices is challenging due to limited sensitivity and line broadening caused by magnetic susceptibility inhomogeneities. We present a novel double-stripline NMR probe head that accommodates planar microfluidic devices, and obtains the NMR spectrum from a rectangular sample chamber on the chip with a volume of 2 l. Finite element analysis is used to jointly optimise the detector and sample volume geometry for sensitivity and RF homogeneity. A prototype of the optimised design has been built, and its properties have been characterised experimentally. The performance in terms of sensitivity and RF homogeneity closely agrees with the numerical predictions. The system reaches a mass limit of detection of 1.57 nMol p s, comparing very favourably with other micro-NMR systems. The spectral resolution of this chipGprobe system is better than 1.75 Hz at a magnetic field of 7 T, with excellent line shape.

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“…(ii) The wireless transfer of energy (signal) from an MR detector, which is enabled by placing a pick‐up coil which is wired to the spectrometer in close proximity to a non‐wired MR detector. The signal recorded by the MR detector is transferred via inductive coupling to the spectrometer and is typically used to access samples within restricted areas,7, 8, 9, 10, 11, 12, 13 to locally enhance the signal‐to‐noise ratio (SNR),14, 15, 16 or to improve the handling comfort of MR probes 17, 18, 19, 20, 21, 22…”

Section: Introductionmentioning

confidence: 99%

A comparison of Lenz lenses and LC resonators for NMR signal enhancement

Jouda

Kamberger

Leupold

et al. 2017

Concepts Magn Reson

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High signal‐to‐noise ratio (SNR) of the NMR signal has always been a key target that drives massive research effort in many fields. Among several parameters, a high filling factor of the MR coil has proven to boost the SNR. In case of small‐volume samples, a high filling factor and thus a high SNR can be achieved through miniaturizing the MR coil. However, under certain circumstances, this can be impractical. In this paper, we present an extensive theoretical and experimental investigation of the inductively coupled LC resonator and the magnetic Lenz lens as two candidate approaches that can enhance the SNR in such circumstances. The results demonstrate that the narrow‐band LC resonator is superior in terms of SNR, while the non‐tuned nature of the Lenz lens makes it preferable in broadband applications.

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Contactless NMR Spectroscopy on a Chip

Cited by 53 publications

References 38 publications

Microscale nuclear magnetic resonance: a tool for soft matter research

Microscale nuclear magnetic resonance: a tool for soft matter research

An optimised detector for in-situ high-resolution NMR in microfluidic devices

A comparison of Lenz lenses and LC resonators for NMR signal enhancement

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