Continuous and Size-Controlled Preparation of Ibuprofen Nanosuspension by Antisolvent Crystallization Method Using Hollow Fiber Membrane

Haghighizadeh, Atoosa; Mahdavi, Hossein; Rajabi, Omid

doi:10.1007/s12247-022-09639-9

Cited by 4 publications

(5 citation statements)

References 38 publications

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“…Membrane-based processes are renowned for their high selectivity, separation efficiency, and low energy requirements which make them ideal for chemical and pharmaceutical drug manufacturing [71,72]. Recently, there has been considerable interest in utilizing membrane separation technology combined with crystallization for producing coated drug particles with improved morphology and finer CSD [73]. In the process of membrane crystallization, effective regulation of spatial and temporal distributions of supersaturation improved the control accuracy of crystallization.…”

Section: Coupled Membrane-antisolvent Crystallizationmentioning

confidence: 99%

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Haghighizadeh,

Mahdavi,

Rajabi

2024

Chem Eng & Technol

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Continuous crystallization of pharmaceuticals has been in the center of attention during the past two decades, with a more focus on the large‐scale production of active pharmaceutical ingredients. The increasing demand for pharmaceuticals requires high‐throughput production of drug crystals with different solubilities, stabilities, shapes, habits, polymorphs, and size distributions. With numerous advantages including low cost, ease of scale‐up, and superior control over polymorph and size distribution of drug crystals, antisolvent crystallization is one of the most promising crystallization methods recently attempted. However, it fails to deliver the required characteristic where the crystal systems tend to grow and for the preparation of metastable polymorphs. This review focuses on the most recent efforts to tackle these drawbacks by coupling antisolvent crystallization with cooling, supercritical‐assisted, microfluidics‐assisted, and membrane‐assisted crystallization. This systematic review aims to provide a concise summary of each coupled antisolvent technique and their positive and negative aspects. This review can be used as a guideline for pharmacist, biologists, and chemists, who are interested in the crystal engineering of pharmaceuticals to pave the way for further developments in this field.

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Section: Coupled Membrane-antisolvent Crystallizationmentioning

confidence: 99%

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Haghighizadeh,

Mahdavi,

Rajabi

2024

Chem Eng & Technol

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“…Supercritical-fluid-based advancements cover a wide range of applications such as extraction, impregnation, formulation, particle formation, sterilization, cleaning, chemical reactions, energy production, and waste treatment. In these applications, supercritical fluids are used instead of traditional organic liquid solvents . By using scCO 2 in many processes, it is greatly possible to reduce or even eliminate solvent residues, consequently contributing to more environmentally friendly chemical processes and promoting the development of green technologies .…”

Section: Introductionmentioning

confidence: 99%

“…In these applications, supercritical fluids are used instead of traditional organic liquid solvents. 35 By using scCO 2 in many processes, it is greatly possible to reduce or even eliminate solvent residues, consequently contributing to more environmentally friendly chemical processes and promoting the development of green technologies. 36 ScCO 2 has shown a great ability in various fields including the extraction of essential oils and seed oils, nanoparticle formation, impregnation, optimization, and polymer synthesis.…”

Section: Introductionmentioning

confidence: 99%

Solubility Measurement and Correlation of Alprazolam in Carbon Dioxide with/without Ethanol at Temperatures from 308 to 338 K and Pressures from 120 to 300 bar

Sajadian,

Bagheri,

Gurikov

et al. 2024

J. Chem. Eng. Data

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This research investigated the solubility of alprazolam in supercritical carbon dioxide (scCO 2 ) with the addition of ethanol as a cosolvent. The solubility was examined at various pressures (ranging from 120 to 300 bar) and temperatures (ranging from 308 to 338 K). The solubility of alprazolam in scCO 2 ranged from 0.027 × 10 −4 to 0.632 × 10 −4 . When ethanol was used as a cosolvent, the solubility increased to a range of 0.157 × 10 −4 to 1.660 × 10 −4 (with 1 mol % ethanol) and 0.449 × 10 −4 to 3.167 × 10 −4 (with 3 mol % ethanol). Under the specified operating parameters, the highest solubility of alprazolam was achieved in the ternary system (with 3 mol % ethanol) at 120 bar and 338 K. This solubility was 16.63 times higher than when using pure scCO 2 under the same circumstances. Several semiempirical correlations were used to compute the solubility of alprazolam in supercritical carbon dioxide. These models yielded similar average absolute relative deviations ranging from 7.0 to 8.40%. The findings demonstrated the superiority of the Kumar−Johnston model in binary systems (with an average absolute relative deviation of 7.0%) and the Garlapati−Madras model in ternary systems (with an average absolute relative deviation of 6.19%) compared to alternative models.

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“…Cyclodextrins belongs to cyclic oligosaccharides family, composed of 6 (in α-cyclodextrins), 7 (in β-cyclodextrins), or 8 (in γ-cyclodextrins) glucose units that were joined by α- (1,4) glycosidic linkages. The use of complexing agent can improve the water-solubilities well as biopharmaceutical and physicochemical properties of drugs.…”

Section: Introductionmentioning

confidence: 99%

“…Because of poor aqueous solubility and high permeability, ibuprofen is classified as a class II drug of the biopharmaceutical classification system (BCS) [3] . To enhance the solubility of ibuprofen in water, various approaches, including crystallization, [4] solid dispersion [5] and complexation with different agents, like phospholipid [6] and cyclodextrins, [7] have been studied.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Optimization, and Evaluation of the Inclusion Complex of Ibuprofen‐Hydroxypropyl‐beta‐cyclodextrin: An in Vitro and in Silico Study“

et al. 2023

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Ibuprofen is a widely-used non-steroidal anti-inflammatory drug, which belongs to class II of Biopharmaceutics classification system with low aqueous solubility and dissolution rate and bioavailability problems. This study was conducted to synthesis, optimization, and evaluation of the inclusion complex of ibuprofen-hydroxypropyl-beta-cyclodextrin to overcome the challenges. Complex of ibuprofen and hydroxypropyl-beta-cyclodextrin (HPβCD) was prepared by co-evaporation method in different ratios of solvents (methanol, ethanol, and distilled water were used as solvent systems). In order to find out the optimum solvent ratio, molecular dynamics simulations were performed by NAMD 2.9 software. Differential scanning calorimetry was applied to assess the complexes crystallinity and thermal behaviors. Also, Fourier transform infrared was used to monitor structural changes. Furthermore, the solubility and dissolution profiles of complexes were evaluated and compared. Complexation with HPβCD was able to reduce crystallinity and improve the thermal stability, water solubility, and dissolution profile of all synthesized complexes. HPβCD complexation using ethanol and water solvents in the ratio of 9 : 1 and 3 : 1, increased the aqueous solubility of ibuprofen by 1155 % and 874 %, respectively that was considered as the optimum approach. The results indicated that complexation with HPβCD may be of potential use for improving the ibuprofen dissolution rate and bioavailability.

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Continuous and Size-Controlled Preparation of Ibuprofen Nanosuspension by Antisolvent Crystallization Method Using Hollow Fiber Membrane

Cited by 4 publications

References 38 publications

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Solubility Measurement and Correlation of Alprazolam in Carbon Dioxide with/without Ethanol at Temperatures from 308 to 338 K and Pressures from 120 to 300 bar

Synthesis, Optimization, and Evaluation of the Inclusion Complex of Ibuprofen‐Hydroxypropyl‐beta‐cyclodextrin: An in Vitro and in Silico Study“

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