Continuous enzymatic stirred tank reactor cascade with unconventional medium yielding high concentrations of (<i>S</i>)-2-hydroxyphenyl propanone and its derivatives

Oeggl, Reinhard; Glaser, Juliane; Lieres, Eric von; Rother, Dörte

doi:10.1039/d0cy01666g

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…Most of the literature covering 2020-2022 deal with the preparation of key building blocks (Al-Shameri et al, 2020;Böhmer et al, 2020;Hegarty and Paradisi, 2020;Roura Padrosa et al, 2020;Oeggl et al, 2021;Semproli et al, 2020;Teepakorn et al, 2021;Azevedo et al, 2022;Peng et al, 2022) for fine chemicals/APIs (2020)(2021)(2022). Frontiers in Catalysis frontiersin.org rather than with the total synthesis of drugs (Rinaldi et al, 2020;Wu et al, 2020;Kazan et al, 2021;Romero-Fernandez and Paradisi, 2021;Benítez-Mateos et al, 2022a;Benítez-Mateos and Paradisi, 2022).…”

Section: Active Pharmaceutical Ingredientsmentioning

confidence: 99%

What’s new in flow biocatalysis? A snapshot of 2020–2022

et al. 2023

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Flow biocatalysis is a key enabling technology that is increasingly being applied to a wide array of reactions with the aim of achieving process intensification, better control of biotransformations, and minimization of waste stream. In this mini-review, selected applications of flow biocatalysis to the preparation of food ingredients, APIs and fat- and oil-derived commodity chemicals, covering the period 2020-2022, are described.

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Section: Active Pharmaceutical Ingredientsmentioning

confidence: 99%

What’s new in flow biocatalysis? A snapshot of 2020–2022

et al. 2023

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3D printing and enzyme immobilization: An overview of current trends

et al. 2023

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Interdisciplinary development of an overall process concept from glucose to 4,5-dimethyl-1,3-dioxolane via 2,3-butanediol

Graf von Westarp,

Wiesenthal,

Spöring

et al. 2023

Commun Chem

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To reduce carbon dioxide emissions, carbon-neutral fuels have recently gained renewed attention. Here we show the development and evaluation of process routes for the production of such a fuel, the cyclic acetal 4,5-dimethyl-1,3-dioxolane, from glucose via 2,3-butanediol. The selected process routes are based on the sequential use of microbes, enzymes and chemo-catalysts in order to exploit the full potential of the different catalyst systems through a tailor-made combination. The catalysts (microbes, enzymes, chemo-catalysts) and the reaction medium selected for each conversion step are key factors in the development of the respective production methods. The production of the intermediate 2,3-butanediol by combined microbial and enzyme catalysis is compared to the conventional microbial route from glucose in terms of specific energy demand and overall yield, with the conventional route remaining more efficient. In order to be competitive with current 2,3-butanediol production, the key performance indicator, enzyme stability to high aldehyde concentrations, needs to be increased. The target value for the enzyme stability is an acetaldehyde concentration of 600 mM, which is higher than the current maximum concentration (200 mM) by a factor of three.

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Continuous enzymatic stirred tank reactor cascade with unconventional medium yielding high concentrations of (S)-2-hydroxyphenyl propanone and its derivatives

Abstract: The implementation of biocatalysis in flow chemistry offers synergistic synthesis advantages in line with green chemistry principles. Yet, the conversion of high substrate concentrations is most often hindered by substrate...

Cited by 3 publications

References 41 publications

What’s new in flow biocatalysis? A snapshot of 2020–2022

What’s new in flow biocatalysis? A snapshot of 2020–2022

3D printing and enzyme immobilization: An overview of current trends

Interdisciplinary development of an overall process concept from glucose to 4,5-dimethyl-1,3-dioxolane via 2,3-butanediol

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