“…25 Serum neuron-specific enolase, a marker of neuron injury, has been demonstrated to be elevated in adults with NCSE 26 and children with continuous epileptiform discharges. 27 Studies in neonates have demonstrated an association between neonatal seizures and poor outcome, especially with more prolonged [28][29][30] and harder-to-control seizures, 31 although the confounding interplay between etiology, seizures, and outcome remains unclear 32 and studies have not proven that treatment improves outcome.…”