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Depts. Peds. and Radiology, McMaster Univ. In adults, there is an inverse relationship between the onset Medical School , Hami 1 ton, Ontario and "University Hospitals of of a simple tone relative to the beginning of a cardiac cycle and 'leveland, Ohio' the duration of the associated interbeat interval. This effect Infants 41500g birth-weight, and expected to survive ~4 8 hours of interest because it reflects the activity of brain areas were randomly assigned to oral *-tocopheral 25mg (E) or drug impinging upon vagal motoneurones independent of baroreceptor vehicle (C) within 2 prognostic strata (B. Wt., and disease sevreflexes. In an investigation of the effects of auditory stimuerity) in 4-patient blocks. Sample-size was determined using lation upon HR response in healthy newborns, we randomly pre-0( = .05, P=0.10 for 50% reduction in incidence of BPD from an sented I-sec, 75 d~-A , 250 Hz squarewave tones to 28 infants. estimated 32%. Stage 111 and IV BPD was diagnosed by 3 indeAnalysis of interbeat interval as a function of the quintile of pendent radiologists on chest x-ray at 3, 4 and 6 weeks. Serum the cardiac cycle in which the onset of the tone occurred, demon-E levels at 1 week were significantly different (E = 2.83 f 0.29, strated that, like adults, the newborn exhibits a longer inter-