Continuous Wavelet Transform for the Resolution of the Overlapping Voltammetric Signals and Simultaneous Determination of Levodopa and Benserazide

Süslü, İncilay; Dinç, Erdal; Demircan, Seyda; Altınöz, Sacide

doi:10.1515/revac.2009.28.2.137

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The main serum metabolite is formed by demethylation at the 4-position of the pyridine ring, followed by conjugation with sulphate. [1][2][3][4] Several techniques have been developed to estimate PAN in its bulk form, pharmaceutical and biological matrices, including liquid chromatography with different detectors, [5][6][7][8][9][10][11][12] UV-spectrophotometry, [13][14][15] and capillary electrophoresis. 16,17 Electrochemical assays such as voltammetric methods have been widely used for drug analysis due to their sensitivity, simplicity, cheapness and rapidity.…”

Section: Introductionmentioning

confidence: 99%

Electrooxidation and Low-tech Determination of Pantoprazole on a Disposable Pencil Graphite Electrode by the use of Cationic Surfactant

Pınar

2020

ACSi

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The electrochemical oxidation of pantoprazole, a selective proton pump inhibitor, was studied in aqueous as well as aqueous/surfactant media at a disposable pencil graphite electrode using cyclic and adsorptive stripping voltammetric techniques. The sensitivity of the stripping voltammetric measurements was significantly improved when the cationic surfactant, cetyltrimethylammonium bromide (CTAB) was present in the neutral electrolyte solution. For analytical purposes, well resolved voltammetric peaks at +1.05 V (versus Ag/AgCl) were obtained in Britton-Robinson buffer at pH 7.0 containing 3 × 10-4 M CTAB using square-wave stripping mode (after 30 s accumulation at open-circuit condition). The process could be used to determine pantoprazole concentrations in the range of 2.4 × 10-8-7.1 × 10-7 M (9.2-272 μg L-1) with a detection limit of 7.0 × 10-9 M (2.7 μg L-1). The proposed method was applied to the determination of pantoprazole in pharmaceutical formulation and in the spiked human urine samples with acceptable recoveries.

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Section: Introductionmentioning

confidence: 99%

Electrooxidation and Low-tech Determination of Pantoprazole on a Disposable Pencil Graphite Electrode by the use of Cationic Surfactant

Pınar

2020

ACSi

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“…Some applications of the CWT approach, combined with the zero crossing technique and ratio signal treatments, have been reported for the spectral quantitative analysis of drugs in commercial pharmaceutical preparations (7)(8)(9)(10)(11)(12)(13)(14)(15). In some previous investigations, the quantitative resolution of overlapping voltammetric peaks was carried out by CWT (16,17).…”

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confidence: 99%

A New Application of Continuous Wavelet Transform to Overlapping Chromatograms for the Quantitative Analysis of Amiloride Hydrochloride and Hydrochlorothiazide in Tablets by Ultra-Performance Liquid Chromatography

Dinç

Büker

2012

Journal of AOAC INTERNATIONAL

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A new application of continuous wavelet transform (CWT) to overlapping peaks in a chromatogram was developed for the quantitative analysis of amiloride hydrochloride (AML) and hydrochlorothiazide (HCT) in tablets. Chromatographic analysis was done by using an ACQUITY ultra-performance LC (UPLC) BEH C18 column (50 x 2.1 mm id, 1.7 pm particle size) and a mobile phase consisting of methanol-0.1 M acetic acid (21 + 79, v/v) at a constant flow rate of 0.3 mL/min with diode array detection at 274 nm. The overlapping chromatographic peaks of the calibration set consisting of AML and HCT mixtures were recorded rapidly by using an ACQUITY UPLC H-Class system. The overlapping UPLC data vectors of AML and HCT drugs and their samples were processed by CWT signal processing methods. The calibration graphs for AML and HCT were computed from the relationship between concentration and areas of chromatographic CWT peaks. The applicability and validity of the improved UPLC-CWT approaches were confirmed by recovery studies and the standard addition technique. The proposed UPLC-CWT methods were applied to the determination of AML and HCT in tablets. The experimental results indicated that the suggested UPLC-CWT signal processing provides accurate and precise results for industrial QC and quantitative evaluation of AML-HCT tablets.

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Voltammetric Study and Direct Analytical Determination of the Antiparkinson Drug Benserazide

et al. 2011

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For the first time, a simple differential pulse voltammetry methodology for direct determination of benserazide in presence of levodopa in tablets was developed without any redox mediator, modified electrodes, or the aplication of mathematic deconvolution of signals. Benserazide was studied by differential pulse voltammetry using glassy carbon electrode in aqueous media. The drug exhibited a main well-defined oxidation signal in a broad pH range (2-10), and two poorly resolved signals at higher potentials. We have found that levodopa does not interfere on the electrochemical response of benserazide at pH 6.0. Thus, at this pH value, the developed analytical method exhibited adequate repeatability and reproducibility (RSD < 2%), recoveries >98.5%, which permitted its successful application to both the assay and the uniformity content of benserazide. Also, hydrolytic degradation studies of benserazide were carried out by differential pulse voltammetry.

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Continuous Wavelet Transform for the Resolution of the Overlapping Voltammetric Signals and Simultaneous Determination of Levodopa and Benserazide

Cited by 4 publications

References 16 publications

Electrooxidation and Low-tech Determination of Pantoprazole on a Disposable Pencil Graphite Electrode by the use of Cationic Surfactant

Electrooxidation and Low-tech Determination of Pantoprazole on a Disposable Pencil Graphite Electrode by the use of Cationic Surfactant

A New Application of Continuous Wavelet Transform to Overlapping Chromatograms for the Quantitative Analysis of Amiloride Hydrochloride and Hydrochlorothiazide in Tablets by Ultra-Performance Liquid Chromatography

Voltammetric Study and Direct Analytical Determination of the Antiparkinson Drug Benserazide

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