Contradictory effect of gold nanoparticle-decorated molybdenum sulfide nanocomposites on amyloid-β-40 aggregation

Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation

“…Regrettably, no corresponding in vivo studies were performed. Liu et al 139 Li et al 142 found that WS 2 nanosheets could effectively inhibit Ab 40 aggregation. Under van der Waals forces and electrostatic interactions, Ab 40 monomers can be selectively adsorbed on the nanosheet surface.…”

Copolymer Polydopamine Nanoparticles as Multifunctional Nanoinhibitors for Modulating β-Amyloid Aggregation

“…In addition, the interaction between Aβ tyrosine and CPDA NPs was explored through endogenous fluorescence experiments (Figure S10). 26 As the concentration of CPDA NPs gradually increased, the fluorescence of tyrosine was gradually quenched. This is mainly because CPDA NPs can strongly bind to tyrosine and phenylalanine of Aβ through aromatic ring interaction (π−π-stacking and hydrophobic interactions), and they can also form hydrogen bonds with Aβ through phenolic hydroxyl groups to interfere with the hydrophobic nucleus of Aβ (Figure S11a).…”

“…To date, various amyloid inhibitors have been designed for the regulation of Aβ aggregation, such as small molecules, , proteins (peptides), aptamers, , polymers, − and nanomaterials. , Among them, nanomaterials have been widely used for the study of the regulation of amyloid aggregation because of their small particle size, large specific surface area, and easy penetration through the blood–brain barrier (BBB). Commonly used nanomaterials, such as gold particles, , nanoselenium, black phosphorus nanosheets, graphene oxide, molybdenum disulfide, quantum dots, and polymeric nanoparticles, have been reported as nanoinhibitors in modulating amyloid aggregation. Most present effective nanoinhibitors functioned with Aβ through noncovalent interactions, such as π–π stacking, hydrogen bonding, electrostatic attraction, and hydrophobic interactions, for preventing Aβ aggregation and reducing Aβ-related cytotoxicity .…”

Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides

“…Wang et al confirmed the inhibition effect of monolayer MoS 2 on the Aβ 33–42 aggregation [ 145 ]. Liu et al reported the concentration-dependent contradictory effect of AuNP-decorated MoS 2 nanocomposites on Aβ 1–40 aggregation [ 146 ]. As displayed in Figure 11 A, a low concentration of AuNP-MoS 2 nanocomposite could act as the nuclei to accelerate the nucleus formation and fibrillation of Aβ 1–40 , but a high concentration of nanocomposites could limit the structural flexibility of Aβ 1–40 , leading to the inhibition of nucleus formation and aggregation.…”

“… ( A ) Schematic illustration of the mechanism of the concentration-dependent effect of AuNP-MoS 2 nanocomposites on Aβ 1–40 aggregation. Reprinted with permission from reference [ 146 ]. Copyright 2019 Elsvier.…”