Contralateral adrenal width predicts the duration of prolonged post‐surgical steroid replacement for subclinical Cushing syndrome

Abstract

Contralateral adrenal width seems to represent a significant predictive factor for the duration of post-surgical steroid replacement in subclinical Cushing syndrome patients. Pre-surgical assessment of image findings might help clinicians determine the total duration of steroid therapy after adrenalectomy.

Spontaneous adrenal hemorrhage with dehydroepiandrosterone‐sulfate elevation in a patient with suspected adrenal cortical carcinoma

“…The patient in the present case showed spontaneous adrenal hemorrhage, and was therefore categorized as a non‐injury case. Only 20–30 cases of spontaneous adrenal hemorrhage have been reported in Japan …”

“…Only 20-30 cases of spontaneous adrenal hemorrhage have been reported in Japan. 1,5,6 The detailed mechanisms of spontaneous adrenal hemorrhage are still unknown. One possible mechanism involves the blood supply of the adrenal gland.…”

A case of subclinical Cushing's syndrome in pregnancy with superimposed preeclampsia

“…Estrogen increase can promote cortisol binding coupled with increases in placental ACTH and corticotrophin‐releasing hormone can lead to increases in free cortisol levels in plasma and the uterus . Moreover, SCS is asymptomatic, and the activity of the tumor varies among patients . This case was complicated by hypertensive disorder of pregnancy in the first trimester; however, the patient showed no sign of preeclampsia at this time.…”

“…Patients with adrenal adenomas can develop subclinical Cushing's syndrome (SCS) due to an excess of cortisol production, without the typical clinical signs and symptoms of Cushing's syndrome (CS). 1 SCS often co-occurs with some diseases like obesity, diabetes mellitus, and hypertension. 2 When a woman's pregnancy is complicated by SCS, the disease course is not well known as SCS during pregnancy is rare.…”

“…3 Moreover, SCS is asymptomatic, and the activity of the tumor varies among patients. 1 This case was complicated by hypertensive disorder of pregnancy in the first trimester; however, the patient showed no sign of preeclampsia at this time. Following this, we suspected preexistent hypertension.…”