Contribution à l’étude du système nerveux des formes adultes et larvaires de <i>Schistosoma mansoni</i> Sambon, 1907 (Trematoda Digenea)

Dei‐Cas, Eduardo; Dhainaut-Courtois, N.; Vernes, A

doi:10.1051/parasite/1980551069

Cited by 13 publications

(2 citation statements)

References 14 publications

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“…Previous studies on the nature and functioning of the trematode neuromuscular system have centred on two species, the human blood fluke, Schistosoma mansoni and the liver fluke, Fasciola hepatica. There is surprisingly little information on the ultrastructure of nerve and muscle tissue (Dixon & Mercer, 1965;Silk & Spence, 1969a, b;Dei-Cas, Dhainaut-Courtois & Vernes, 1980;Dei-Cas, Dhainaut-Courtois & Biguet, 1981). 5 .…”

Section: Introductionmentioning

confidence: 99%

The effects of cholinergic and serotoninergic drugs on motility in vitro of Haplometra cylindracea (Trematoda: Digenea)

et al. 1989

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The spontaneous activity of the somatic muscle of the amphibian lung fluke, Haplometra cylindracea has been recorded in vitro, using an isometric force transducer system. Normal movement consisted of a continuous series of regular contractions which were maintained for over 4 h. Acetylcholine (ACh) inhibited motility at a concentration of 1 X 10(-3)M induced a flaccid paralysis. A similar response occurred with the cholinomimetric drugs, carbachol and nicotine, although in these instances the inhibition was less easily reversed by washing with frog Ringer. The inhibitory effect of ACh was blocked by d-tubocurarine but not by atropine. Serotonin (5-HT) caused an increase in the frequency and amplitude of contractions and the effect was blocked by methysergide. No uniform response was observed with 3-hydroxytryptamine (3-HT), but both reserpine and fluoxetine inhibited worm movement. Results suggest that the somatic musculature of the worm is controlled, at least in part, by an inhibitory cholinergic and an excitatory serotoninergic system.

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Section: Introductionmentioning

confidence: 99%

The effects of cholinergic and serotoninergic drugs on motility in vitro of Haplometra cylindracea (Trematoda: Digenea)

et al. 1989

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“…Stimulation by mecamylamine was also blocked by depletion of 5-HT with reserpine and chlorimipramine (Tomosky, Bennett & Bueding, 1974). The pharmacological evidence which all pointed to the role of 5-HT in neurotransmission in schistosomes, has been strengthened with the demon-stration that labelled 5-HT localized in nerve fibres containing dense granules (Dei-Cas, Dhainaut-Courtois, Dhainaut & Vernes, 1979;Dei-Cas, Dhainaut-Courtois & Biguet, 1981). The granules in peripheral axons contain Na + and Ca 2+ (Shaw, Davies & Erasmus, 1982) but their role remains to be determined.…”

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confidence: 99%

Recent advances in schistosome biochemistry

Coles

1984

Parasitology

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Neural and glandular localisation of substance P inEchinostoma caproni (Trematoda-Digenea)

Richard

Klein²,

Stoeckel³

1989

Parasitol Res

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Immunocytochemical studies using antibodies against various peptides were performed on Echinostoma caproni. Only the presence of substance P or a related peptide was clearly demonstrated in this digenetic trematode. In the central nervous system, substance P-immunoreactive neurons were few and constituted two populations according to their size. Labelled axons were observed in the ventral and dorsal nerve cords. Scarce, small neurons and fibres were detected in the peripheral nervous system. The comparative study of 6- and 14-day-old worms showed an overall increase in substance P-immunoreactive nerve structures in the latter. Strong immunoreactivity for substance P was found in prostate cells from 14-day-old worms, whereas none was observed in 6-day-old worms. Thus, positive immunoreactivity seemed to be related to sexual maturity.

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Contribution à l’étude du système nerveux des formes adultes et larvaires de Schistosoma mansoni Sambon, 1907 (Trematoda Digenea)

Cited by 13 publications

References 14 publications

The effects of cholinergic and serotoninergic drugs on motility in vitro of Haplometra cylindracea (Trematoda: Digenea)

The effects of cholinergic and serotoninergic drugs on motility in vitro of Haplometra cylindracea (Trematoda: Digenea)

Recent advances in schistosome biochemistry

Neural and glandular localisation of substance P inEchinostoma caproni (Trematoda-Digenea)

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