Contribution à la phytochimie du genre <i>Gentiana</i> III. Etude des composés flavoniques et xanthoniques dans les feuilles de <i>Gentiana lutea</i> L. (2me communication)

Hostettmann, Kurt; Bellmann, Günter; Tabacchi, Raffaele; Jacot‐Guillarmod, André

doi:10.1002/hlca.19730560842

Cited by 43 publications

(10 citation statements)

References 6 publications

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“…The polyphenol composition of G. lutea reported in our study is in accordance with previous reports [6,8,11]. The xanthones mangiferin (10), gentioside (14) and isogentisine (15) were present in all analyzed samples, thus indicating the common xanthones pattern.…”

supporting

confidence: 92%

Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae Luteae Folium) Grown in Northern Regions of Montenegro

Balijagic

Janković

Zdunić

et al. 2012

Natural Product Communications

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LC-ESI-MS and HPLC were used for the identification of the constituents from G. lutea leaves collected at different localities, as well as for quantification of the main compounds. Seven secoiridoids, five C-glucoflavones and three xanthones, were identified. Swertiamarin derivatives, namely eustomorusside (2), eustomoside (3) and septemfidoside (5), were detected in G. lutea for the first time. Concentrations of five constituents (swertiamarin, gentiopicrin, isovitexin, mangiferin and isogentisin) were determined. The relationship between concentrations of γ-pyrones and altitude was observed with statistically significant correlation (r = 0.94). The extracts were also evaluated for their content of total phenolics, and antiradical and cytotoxic activities. The total phenolics content ranged from 7.7 to 12.7 mg GAE/g, and the IC 50 values for DPPH radical scavenging activity varied between 0.45 to 2.02 mg/mL. The leaf extract exhibited moderate cytotoxic effects toward HeLa cells with an IC 50 value of 41.1 µg/mL, while gentiopicrin, mangiferin and isogentisin exerted strong activity against HeLa cells, with IC 50 values ranging from 5.7 to 8.8 µg/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents.

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supporting

confidence: 92%

Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae Luteae Folium) Grown in Northern Regions of Montenegro

Balijagic

Janković

Zdunić

et al. 2012

Natural Product Communications

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“…Three new (1-3) and three previously identified (4-6) cinnamoyl-C-glucosylflavones have been isolated from the leaves of Gentiana punctata L. The structures of the new compounds were established as: trans-cafeoyl-2"-iso-orientin- 4 (7) were also isolated and identified.…”

Section: Discussionmentioning

confidence: 92%

“…Isolement des composks. L'extraction a Ct C rCalisCe comme dCcrit prCcCdemment [4]. Toutes les substances ont tte obtenues a partir de la fraction mtthanolique traitee selon le schtma de separation indiquk.…”

unclassified

Contribution à la phytochimie du genre Gentiana XXI; Les cinnamoyl‐C‐glucosylflavones et leurs O‐glucosides dans Gentiana punctataL.

Luong

Jacot‐Guillarmod

1977

Helvetica Chimica Acta

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DCdie au Professeur Y. R. Naves h l'occasion de son 75e anniversaire (25.VII.77) Phytochemistry of genus Gentiana XXI: The cinnamoyl-C-glucosylflavones and their O-glucosides in Gentiana punctata L. SummaryThree new (1-3) and three previously identified (4-6) cinnamoyl-C-glucosylflavones have been isolated from the leaves of Gentiana punctata L. The structures of the new compounds were established as: trans-cafeoyl-2"-iso-orientin-4'-O-~-~glucoside (I), trans-feruloy~-2"-isovitexin-4'-O-~-~-glucoside (2) and trans-feruloyl-2"-isovitexin (3). Isoscoparine (8) and O-~-~-glucosyl-2"-iso-orientin (7) were also isolated and identified.

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“…-Zsolernent du composk 1. L'extraction a ttt realiste comme prtckdemment [3]. La substance 1 a Ctt obtenue a partir de l'extrait methanolique selon le schema de separation ci-apres.…”

Section: '-O-[o-~-~-glucosyl-4-cafeoyl-(e)1-2"-isoorientine (2)unclassified

Contribution à la phytochimie du genre Gentiana. XXVI.. Identification d'une nouvelle di‐O‐glucosyl cinnamoyl‐C‐glucosylflavone extraite des feuilles de Gentiana X marcailhouana RY.

Luong

Saeby

Fombasso

et al. 1981

Helvetica Chimica Acta

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Contribution à la phytochimie du genre Gentiana III. Etude des composés flavoniques et xanthoniques dans les feuilles de Gentiana lutea L. (2me communication)

Cited by 43 publications

References 6 publications

Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae Luteae Folium) Grown in Northern Regions of Montenegro

Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae Luteae Folium) Grown in Northern Regions of Montenegro

Contribution à la phytochimie du genre Gentiana XXI; Les cinnamoyl‐C‐glucosylflavones et leurs O‐glucosides dans Gentiana punctataL.

Contribution à la phytochimie du genre Gentiana. XXVI.. Identification d'une nouvelle di‐O‐glucosyl cinnamoyl‐C‐glucosylflavone extraite des feuilles de Gentiana X marcailhouana RY.

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