Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: Comparison of leptin and adiponectin

Sugiura, Kaichiro; Koji, Takehiko; Yatsuya, Hiroshi; Otsuka, Rei; Wada, Keiko; Matsushita, Kunihiro; Kondo, Takahisa; Hotta, Yo; Mitsuhashi, Hirotsugu; Murohara, Toyoaki; Toyoshima, Hideaki

doi:10.1016/j.ijcard.2008.01.006

Cited by 13 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It might have been due to relatively small sample size. Adiponectin has been found to correlate negatively with CRP 24. We found that hsCRP was negatively correlated with adiponectin concentrations in HF patients with MetS, although not in all HF patients.…”

Section: Discussionmentioning

confidence: 49%

Plasma Adiponectin Concentration and Its Association with Metabolic Syndrome in Patients with Heart Failure

et al. 2012

View full text Add to dashboard Cite

PurposePlasma adiponectin concentrations are inversely related with metabolic syndrome (MetS), and MetS is associated with increased risk for heart failure (HF). However, the relationship between adiponectin and MetS in HF remains undetermined. Therefore, we tested whether MetS was associated with the degree of plasma adiponectin concentrations in HF patients.Materials and MethodsOne hundred twenty eight ambulatory HF patients with left ventricular ejection fraction of <50% (80 males, 61.8±11.9 years old) were enrolled for this cross-sectional study. Echocardiographic measurements were performed, and plasma concentrations of adiponectin, lipoproteins, apolipoproteins (apoB, apoA1) and high sensitive C-reactive protein (hsCRP) were measured.ResultsAdiponectin concentrations in HF patients with MetS (n=43) were significantly lower than those without MetS (n=85) (9.7±7.0 vs. 15.8±10.9 µg/mL, p=0.001). Higher concentrations of apoB (p=0.017), apoB/A1 ratio (p<0.001), blood urea nitrogen (p=0.034), creatinine (p=0.003), and fasting insulin (p=0.004) were observed in HF patients with MetS compared with those without MetS. In HF patients with MetS, adiponectin concentrations were negatively correlated with hsCRP (r=-0.388, p=0.015) and positively correlated with the ratio of early mitral inflow velocity to early diastolic mitral annular velocity, E/E' (r=0.399, p=0.015). There was a significant trend towards decreased adiponectin concentrations with an increasing number of components of MetS (p for trend=0.012).ConclusionOur study demonstrated that adiponectin concentrations decreased in HF patients with MetS, and that relationship between adiponectin, inflammation and abnormal diastolic function, possibly leading to the progression of HF.

show abstract

Section: Discussionmentioning

confidence: 49%

Plasma Adiponectin Concentration and Its Association with Metabolic Syndrome in Patients with Heart Failure

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The authors suggested that the ratio of HMW-ApN to CRP might serve as a robust biomarker for the prediction of MetS [5]. Sugiura et al in a study of 2049 Japanese men aged 35 to 66 reported the negative association of ApN with CRP, independently of leptin, proposing a possible inhibitory effect of ApN in CRP synthesis through modulations in TNF-α and IL-6 productions [6]. Similar results were also shown in other, large scale crosssectional studies [7][8][9][10].…”

supporting

confidence: 57%

Biomarkers predicting metabolic syndrome: The role of adiponectin and systemic inflammation

Marinou¹,

Vaiopoulos²,

Koutsilieris³

2012

International Journal of Cardiology

View full text Add to dashboard Cite

“…In adipose tissue, an inverse relationship between CRP and adiponectin mRNA has been described [17]. In Japanese men, both leptin (negatively) and adiponectin (positively) are independently associated with CRP concentration [30]. Leptin is more strongly related to CRP levels than adiponectin, especially among obese men [30].…”

Section: Discussionmentioning

confidence: 99%

“…In Japanese men, both leptin (negatively) and adiponectin (positively) are independently associated with CRP concentration [30]. Leptin is more strongly related to CRP levels than adiponectin, especially among obese men [30]. Among women of the DRECAN-05 population, leptin concentration highly correlated with CRP and BMI [8].…”

Section: Discussionmentioning

confidence: 99%

Influence of smoking and body weight on adipokines in middle aged women

Bergmann

Siekmeier

2009

Eur J Med Res

View full text Add to dashboard Cite

ObjectiveQuitting smoking was associated with an undesirable weight gain. Both, cigarette smoking and obesity were accompanied by subclinical systemic inflammation. This may cause unfavourable changes in (plasma) adipokine concentration. The aim of the present study was to establish the influence of moderate cigarette smoking on the concentration of the adipokines leptin and adiponectin and the pro-inflammatory factors CRP, SAA, IL-6 and TNF-α in non-obese (n = 138) and obese (n = 175) perimenopausal women of the DRECAN-2005 survey.ResultsAmong non-obese women, adiponectin was significantly lower in smokers than in non-smokers (16.88 ± 6.85 vs. 20.63 ± 10.04 μg/ml; P < 0.05). Leptin tended to lower values, too. Among obese women, none significant differences in adiponectin or leptin concentration were observed between smokers and non-smokers. In obese smokers and obese non-smokers, the adiponectin concentrations were significantly lower and the leptin concentrations were significantly higher than in non-obese non-smokers. Non-obese smokers showed significantly higher leukocyte count (6.50 ± 1.83 vs. 5.51 ± 1.31 GPT/l; P < 0.001) and serum amyloid A concentration (7.81 ± 1.25 vs. 4.22 ± 1.43 mg/l; P < 0.05) than non-obese non-smokers. There were only tendencies to higher concentration of CRP, IL-6, and TNF-α. In obese women, moderate cigarette smoking was not associated with higher leukocyte count or concentration of SAA. Among non-smokers, overweight was associated higher concentration of leptin (22.16 ± 12.16 vs. 11.49 ± 6.37 ng/ml; P < 0.001) and with significantly lower concentration of adiponectin (16.29 ± 8.01 vs. 20.77 ± 9.99 μg/ml; P < 0.001). Among smokers, overweight was associated with higher leptin concentration only (obese: 18.62 ± 13.46 vs. non-obese: 8.84 ± 4.92 ng/ml; P < 0.01).ConclusionsIn non-obese middle aged women, even moderate cigarette smoking adversely influences the serum concentration of adiponectin and SAA. Over-weight hides possible effects of smoking on cytokines and adipokines.

show abstract

Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: Comparison of leptin and adiponectin

Cited by 13 publications

References 37 publications

Plasma Adiponectin Concentration and Its Association with Metabolic Syndrome in Patients with Heart Failure

Plasma Adiponectin Concentration and Its Association with Metabolic Syndrome in Patients with Heart Failure

Biomarkers predicting metabolic syndrome: The role of adiponectin and systemic inflammation

Influence of smoking and body weight on adipokines in middle aged women

Contact Info

Product

Resources

About