Contribution of known endocrine disrupting substances to the estrogenic activity in Tama River water samples from Japan using instrumental analysis and in vitro reporter gene assay

Monitoring of selected estrogenic compounds and estrogenic activity in surface water and sediment of the Yellow River in China using combined chemical and biological tools

“…The concentrations of E1 in the Yellow river water are lower than those in the Pearl River (Zhao et al, 2009), Dan-Shui River of China , Tama River of Japan (Furuichi et al, 2004) and streams of USA (Kolpin et al, 2002), but higher than those in the lakes and rivers of Korea and the Venice lagoon of Italy (Pojana et al, 2007), and comparable to those in surface water samples of Australia (Hohenblum et al, 2004;Ying et al, 2009) (Table 2). Estradiol (E2) was only detected at 2.3 ng/L in site 4 of the Yellow River.…”

“…The concentration range for 4-NP found in the present study is consistent with previous results in the Yellow River reported by Xu et al (2006) and Wang et al (2006) from 34.2 to 599 ng/L and 50 to 170 ng/L, respectively. 4-t-OP and BPA were also detected at all sampling sites (Table 2) and have been widely detected in aquatic environments, usually at levels of several to hundreds of nanograms per liter (Boyd et al, 2004;Furuichi et al, 2004;Kuch and Ballschmiter, 2001). Both levels and detection frequencies of 4-t-OP and BPA in the water of the Yellow River appear lower than those in the Pearl River (Zhao et al, 2009), Hai River (Jin et al, 2004) of China, the Tama River of Japan (Furuichi et al, 2004), but similar to those in the Ouse River of UK (Zhang et al, 2006) and Venice lagoon of Italy (Pojana et al, 2007) (Table 2).…”

“…4-t-OP and BPA were also detected at all sampling sites (Table 2) and have been widely detected in aquatic environments, usually at levels of several to hundreds of nanograms per liter (Boyd et al, 2004;Furuichi et al, 2004;Kuch and Ballschmiter, 2001). Both levels and detection frequencies of 4-t-OP and BPA in the water of the Yellow River appear lower than those in the Pearl River (Zhao et al, 2009), Hai River (Jin et al, 2004) of China, the Tama River of Japan (Furuichi et al, 2004), but similar to those in the Ouse River of UK (Zhang et al, 2006) and Venice lagoon of Italy (Pojana et al, 2007) (Table 2). TCS is a broad-spectrum antimicrobial and preservative agent that is widely used in personal care products (Stasinakis et al, 2008) and it had a frequency of detection of 97% in the Yellow River.…”

“…This study Chen et al, 2006;Peng et al, 2006;Zhao et al, 2009, 2011Jin et al, 2004Chen et al, 2007Khim et al, 1999Ko et al, 2007;Kim et al, 2007;Li et al, 2004Furuichi et al, 2004Hohenblum et al, 2004;Isobe et al, 2001Hibberd et al, 2009Liu et al, 2004;Petrovic et al, 2002;Zhang et al, 2006Pojana et al, 2007Hohenblum et al, 2004Ying et al, 2009Kolpin et al, 2002Stuart et al, 2005 a Concentration range: minimum to maximum (median). weak based on the calculated pseudo-partitioning coefficients: 0e598 L/kg, 14e287 L/kg, 0e192 L/kg and 0e383 L/kg for 4-t-OP, 4-NP, BPA and TCS.…”

Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay

“…In risk assessment, by comparing EEQs obtained from both analytical determination and bioassay, the major and minor contributors of a complex sample could be identified. When this was applied to environmental waters, some work reported that the predicted overall EEQs were similar to observed ones (Beck et al, 2006;Jiang et al, 2012;Liscio et al, 2009), but some found that the predictions were higher or lower (Cargouët et al, 2004;Furuichi et al, 2004). These contradictory conclusions may result from the contribution of non-targets chemicals such as unknown estrogen agonist, antagonist and humics, or the multiple involved modes of action (MoAs) and the resulting interaction of mixture components (Villeneuve et al, 2000).…”