Contribution of leukocytes to the induction and resolution of the acute inflammatory response in chickens

More-Bayona, Juan; Karuppannan, Anbu K.; Barreda, Daniel R.

doi:10.1016/j.dci.2017.04.018

Cited by 14 publications

(13 citation statements)

References 41 publications

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“…A successful immune response relies on the efficient activation of host defense mechanisms (33). Major burn injury induces a profound inflammatory response and, in severe cases, can lead to multiple organ failure or death.…”

Section: Discussionmentioning

confidence: 99%

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Zhang

Ying

et al. 2020

Food & Nutrition Research

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Background: As an important nutrient, soybean protein-derived peptides (SPP) affect the immune function of animals. Objective: This study describes the effects of nutrient supplementation with SPP on the negative nitrogen balance in the burn injury-induced inflammatory response of aged rats. Design: Soybean protein isolate (SPI) was hydrolyzed to obtain SPP. A negative nitrogen-balance aged rat model and a major full-thickness 30% total body surface area (TBSA) burn-injury rat model were utilized. Results: The results show that SPP can increase the speed and ability of inflammatory stress by adjusting white blood cell counts. Soybean protein-derived peptides significantly increased serum immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) levels; significantly decreased serum interleukin-1 beta (IL-β), tumor necrosis factor-alpha (TNF-α) and regulated upon activation normal T-cell expressed and secreted (RANTES) levels. These results give conclusive evidence that SPP has a significantly positive effect in improving the immune function on the condition of negative nitrogen balance with burn-injury, and reducing excessive inflammation. Conclusions: Nutrient supplementation of SPP can, therefore, be used as an adjuvant treatment to inhibit the development and severity of inflammatory reactions caused by burns, providing a novel therapy for the treatment and positive prognosis of burn patients.

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Section: Discussionmentioning

confidence: 99%

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Zhang

Ying

et al. 2020

Food & Nutrition Research

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“…Also, significant interaction between time and treatment was observed (P < 0.05), evident at both d 14 and d 35 (Figures 2A-D). We have previously shown that heterophils are the dominant leukocyte recruited into the abdominal cavity following zymosan challenge in chickens (18). These cells fill a role as the first responders against bacterial, fungal, and viral infections (30).…”

Section: Leukocyte Recruitment Into the Abdominal Challenge Site And mentioning

confidence: 99%

“…Induction of an intra-abdominal acute inflammation was derived from a custom protocol previously validated in our laboratory (18). Briefly, zymosan A from Saccharomyces cerevisiae (2.5 mg, Sigma-Aldrich) was resuspended in 500 ml of PBS −/− (no calcium/no magnesium) and administered through injection into the abdominal cavity to induce inflammation response.…”

Section: Intra-abdominal Injectionsmentioning

confidence: 99%

Impact of Reduced Dietary Crude Protein in the Starter Phase on Immune Development and Response of Broilers Throughout the Growth Period

Kamely

Wakaruk

et al. 2020

Front. Vet. Sci.

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Crude protein (CP) levels in commercial broiler (Gallus gallus) diets, optimized for maximum yield production vs. feed cost, have only begun to be assessed for impact on immune function. In order to study immune effects of dietary CP levels, different starter phase (day 1-14) diets were fed to 230 Ross 708 male broiler chicks randomly assigned at 1 day of age into two treatment groups. Group 1: Standard diet (STD) contained 3,000 kcal AMEn/kg energy and 23.78% CP; and Group 2: Reduced crude protein diet (RCP) contained 3,000 kcal AMEn/kg energy and 21.23% CP. From day 15-35 a common standard grower/finisher diet (3,150 kcal AMEn/kg energy and 22.18% CP) was allocated to both groups. Zymosan, a glycan derived from yeast cell walls that binds to TLR 2 and Dectin-1, was used for intra-abdominal challenge. Results demonstrated that a reduced crude protein starter diet (21.23 vs. 23.78% CP) between age 1-14, while maintaining the same levels of metabolizable energy and essential amino acids, did not affect broilers growth performance or lymphoid organ weights (P > 0.05). Interestingly, basal leukocyte levels in the RCP group significantly (P < 0.01) increased in the blood compartment at d35 in the unchallenged birds. Significant enhancements to leukocyte infiltration into the abdominal cavity were also detected post-immune challenge with zymosan (day 14 and day 35; P < 0.01). Post-challenge levels of TNF-α, IL-1β, and CXCL8 gene expression cells collected from the abdominal cavity were not affected by the diets (P > 0.05). Moreover, dietary treatments did not influence percentage of ROS producing cells in the abdominal cavity (P > 0.05). To our best knowledge, this is the first study that reports the impacts of reduced crude protein diet on the innate immune response of poultry to an acute inflammation model in the abdominal cavity. Overall, our results highlight that reduced crude protein diets can be used without negatively impacting broiler performance and may enhance the capacity of broilers to recruit leukocytes upon infection.

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“…There was no effect of diet or ME intake on the number of peripheral leukocytes or the heterophil to lymphocyte ( H:L ) ratio ( Table 10 ). High H:L ratios are used as an indicator of chronic stress, and the number of leukocytes provides one indicator of the systemic immune status ( More Bayona et al., 2017 ). Higher H:L ratios have been observed in restricted birds than in ad libitum fed birds in some studies ( Maxwell et al., 1992 , Hocking et al., 1993 , Hocking et al., 1996 , Savory et al., 1993 ) but not in other studies ( van Niekerk et al., 1988 , Katanbaf et al., 1989 , Maxwell et al., 1990 , Savory et al., 1996 , Jong et al., 2002 ).…”

Section: Resultsmentioning

confidence: 99%

“… Klasing (2007) indicated that at maintenance, a young broiler uses about 0.5% of the body's lysine for leukocytes, antibodies, and accessory proteins and that the resting immune system uses about 1.2% of the lysine intake in a healthy growing broiler chick. In addition, a difference in the immune system between feed-restricted and ad libitum birds may also originate from differences in the responsiveness of leukocytes ( More Bayona et al., 2017 ). In this regard, an assessment of immune function would provide a deeper understanding of immune changes due to feed restriction.…”

Section: Resultsmentioning

confidence: 99%

Comparison of mathematical and comparative slaughter methodologies for determination of heat production and energy retention in broilers

et al. 2020

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Understanding factors affecting ME availability for productive processes is an important step in optimal feed formulation. This study compared a modelling methodology with the comparative slaughter technique ( CST ) to estimate energy partitioning to heat production and energy retention ( RE ) and to investigate differences in heat dissipation. At hatch, 50 broilers were randomly allocated in one of 4 pens equipped with a precision feeding station. From day 14 to day 45, they were either fed with a low-ME (3,111 kcal/kg ME) or a high-ME (3,383 kcal/kg ME) diet. At day 19, birds were assigned to pair-feeding in groups of 6 with lead birds eating ad libitum (100%) and follow birds eating at either 50, 60, 70, 80, or 90% of the paired lead's cumulative feed intake. Heat production and RE were estimated by CST and with a nonlinear mixed model explaining daily ME intake ( MEI ) as a function of metabolic BW and average daily gain ( ADG ). The energy partitioning model predicted MEI = (145.10 + u ) BW 0.83 + 1.09 × BW −0.18 × ADG 1.19 + ε. The model underestimated heat production by 13.4% and overestimated RE by 22.8% compared with the CST. The model was not able to distinguish between net energy for gain values of the diets (1,448 ± 18.5 kcal/kg vs. 1,493 ± 18.0 kcal/kg for the low-ME and high-ME diet, respectively), whereas the CST found a 148 kcal/kg difference between the low-ME and high-ME diets (1,101 ± 22.5 kcal/kg vs. 1,249 ± 22.0 kcal/kg, respectively). The estimates of the net energy for gain values of the 2 diets decreased with increasing feed restriction. The heat increment of feeding did not differ between birds fed with the low- or high-ME diet (26% of MEI). Additional measurements on heat dissipation, physical activity, and immune status indicated that the energetic content of the diet and feed restriction affect some parameters (shank temperature, feeding station visits) but not others (leukocyte counts, heterophil to lymphocyte ratio, and immune cell function).

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Contribution of leukocytes to the induction and resolution of the acute inflammatory response in chickens

Cited by 14 publications

References 41 publications

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Impact of Reduced Dietary Crude Protein in the Starter Phase on Immune Development and Response of Broilers Throughout the Growth Period

Comparison of mathematical and comparative slaughter methodologies for determination of heat production and energy retention in broilers

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