Contribution of the 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography to the diagnosis of primary osseous Hodgkin lymphoma

Breibach, Florence; Julian, Anne; Laurent, Césari; Anglade, Eric; Constantin, Arnaud; Sans, N.; Tricoire, J; Brousset, Pierre; Delisle, Marie–Bernadette; Gomez‐Brouchet, Anne

doi:10.1136/bcr.08.2008.0696

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…The recent studies suggest that 2-[18 F]-fluoro-2-deoxy- d -glucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) enables systemic HL with secondary bone invasion to be distinguished from primitive osseous HL. This technique is highly specific in demonstrating the isolated osseous localization of the tumor and should be recommended in all patients with putative osseous lymphoma [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Unusual primary osseous Hodgkin lymphoma in rib with associated soft tissue mass: a case report and review of literature

Wang

Tian

et al. 2012

Diagn Pathol

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Hodgkin lymphoma (HL) typically presents as nodal lesion and may involve extranodal sites during the progression of the disease. Primary osseous HL without any lymph node association is extremely rare and only a few such cases have been described in the literature. We present a case of unusual primary HL in rib occurring in a middle-aged female patient. Computed tomography (CT) scan revealed an osteolytic lesion was located at the right second rib and was associated with a large soft tissue mass. There was no regional lymph node involvement. CT scan of neck and abdomen was performed and showed no pathologic findings, particularly no lymphadenopathy and organomegaly could be observed. Histologically, typical binucleated Reed-Sternberg (RS) cells and lacunar cells were scattered in the background of reactive inflammation with infiltration of lymphocytes, histiocytes and eosinophilic granulocytes. By immunohistochemistry, RS cells and lacunar cells were positive for CD15 and CD30 with typical membrane and paranuclear dot-like staining pattern. However, these cells were negative for Epstein-Barr virus detection by in situ hybridization. A diagnosis of primary osseous HL was made. The patient received systemic chemotherapy and local radiotherapy, and was on regular follow-up for 24 months. There was no sign of recurrence of tumor and lymph node or bone marrow involvement. Because there is a possibility of secondary bone involvement by systemic HL, strict histological analysis and thorough radiographic examination are suggested to be necessary for accurately diagnosing this tumor when it presents as a solitary bone lesion.Virtual slidesThe virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/2846916171507084

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Section: Resultsmentioning

confidence: 99%

Unusual primary osseous Hodgkin lymphoma in rib with associated soft tissue mass: a case report and review of literature

Wang

Tian

et al. 2012

Diagn Pathol

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“…An additional question remains as to whether multifocal cortical bone disease represents more advanced disease and should, therefore, be staged and treated accordingly. There are no guidelines regarding the use of chemotherapy versus radiotherapy or a combination of the two in cases of isolated or multifocal bony lesions . It does not appear that one treatment modality is superior to another or to a combination of chemotherapy and radiotherapy, as all the case reports reviewed reported favorable outcomes regardless of the treatment chosen.…”

Section: Discussionmentioning

confidence: 99%

“…The most frequently used regimen (n = 10) was adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD). 6,9,13,31,33,34,37,38 Ten patients received chemotherapy alone, 7,9,13,29,31,33,34,37,38,43 whereas six received combined modality treatment with chemotherapy and radiation. 6,13,15,32,33 One report did not mention the treatment used, nor did it comment on survival.…”

Section: Hl With Primary Bony Involvementmentioning

confidence: 99%

“…There are no guidelines regarding the use of chemotherapy versus radiotherapy or a combination of the two in cases of isolated or multifocal bony lesions. [32][33][34][35][36][37][38][39]43 It does not appear that one treatment modality is superior to another or to a combination of chemotherapy and radiotherapy, as all the case reports reviewed reported favorable outcomes regardless of the treatment chosen.…”

Section: Hl With Metastatic Bone Involvementmentioning

confidence: 99%

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Definition of cortical bone involvement in the staging of newly diagnosed pediatric Hodgkin lymphoma: A report from the International Working Group on Staging Evaluation and Response Criteria Harmonization (SEARCH)

Lewis

McCarten

Kurch

et al. 2019

Pediatric Blood & Cancer

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Background The International Working Group on Staging Evaluation and Response Criteria Harmonization (SEARCH) seeks to provide a universally acceptable definition of cortical bone involvement in the staging of newly diagnosed pediatric Hodgkin lymphoma. Procedure A comprehensive literature search was performed using PubMed and Google Scholar with the search terms “Hodgkin lymphoma,” “osseous lesions,” “bony involvement,” and “pediatric.” Publications reviewed included case reports, retrospective analyses, and literature reviews. Each was evaluated for study design, number of participants, median age and age range at diagnosis, percentage of pediatric patients, criteria of interest definition, diagnostic tools, study objectives, and level of evidence. The final definition was based on the available data and consensus of the SEARCH working group. Results Twenty‐five papers specifically addressing cortical bone involvement in Hodgkin lymphoma met the inclusion criteria. Eighteen papers were case reports with literature reviews; the remainder were observational cohort studies. Of these, 14 included pediatric patients (aged 0‐21 years). The criteria for cortical bone involvement were not clearly defined in any paper, often varied within a study, and were inconsistent between publications. Conclusions The SEARCH group for Childhood, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL) proposes the following criteria as defining cortical bone involvement: any cortical bone biopsy‐proven lesion; a positive bony window lesion on computer tomography (CT), with an FDG‐PET positive correlate in a patient with biopsy‐proven Hodgkin lymphoma, if there is no other typical skeletal pathology; auspicious skeletal lesions on FDG‐PET or magnetic resonance imaging should be confirmed by CT or Tc‐99m scan to distinguish cortical lesions from bone marrow involvement. Nodal masses that extend into bone with bony destruction are considered extranodal extension or “E” lesions and do not represent metastatic or stage IV disease.

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“…5) diagnosed on FDG PET or PET/CT that show intense FDG uptake. [24][25][26] The prognosis depends on the response to systemic chemotherapy, and proper evaluation for treatment effectiveness is essential. FDG PET/CT has been reported to be superior to CT and MRI for the evaluation of response to therapy, and it plays a major role in decision making about further management of primary bone lymphoma.…”

Section: Primary Bone Lymphomamentioning

confidence: 99%

PET/CT in Benign and Malignant Musculoskeletal Tumors and Tumor-Like Conditions

Choi

Kim

Yang

2014

Semin Musculoskelet Radiol

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This article briefly reviews malignant bone tumors, diffuse marrow infiltrating diseases, and other benign bone diseases with fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) that should be differentiated from malignant tumors. Clinical use of FDG PET/CT in (1) primary malignant bone tumors including osteosarcoma, malignant fibrous histiocytoma, and primary bone lymphoma, (2) hematopoietic tumors with bone marrow involvement, such as plasmacytoma, multiple myeloma, lymphoma and leukemia, and (3) benign tumors and tumor-like lesions including hemangioma, neurogenic tumor, fibrous dysplasia, and nodular fasciitis are presented, with an emphasis on various imaging findings on FDG PET/CT. Benign tumors and tumor-like conditions are often incidentally detected on FDG PET/CT in serial follow-up studies of cancer patients and should be differentiated from metastasis.

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Contribution of the 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography to the diagnosis of primary osseous Hodgkin lymphoma

Cited by 8 publications

References 28 publications

Unusual primary osseous Hodgkin lymphoma in rib with associated soft tissue mass: a case report and review of literature

Unusual primary osseous Hodgkin lymphoma in rib with associated soft tissue mass: a case report and review of literature

Definition of cortical bone involvement in the staging of newly diagnosed pediatric Hodgkin lymphoma: A report from the International Working Group on Staging Evaluation and Response Criteria Harmonization (SEARCH)

PET/CT in Benign and Malignant Musculoskeletal Tumors and Tumor-Like Conditions

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