Control of Biohazards: A High Performance Energetic Polycyclized Iodine-Containing Biocide

Zhao, Gang; He, Chunlin; Zhou, Wenfeng; Hooper, Joseph P.; Imler, Gregory H.; Parrish, Damon A.; Shreeve, Jean’ne M.

doi:10.1021/acs.inorgchem.8b01600

Cited by 24 publications

(29 citation statements)

References 19 publications

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“…Inorganic antimicrobial agents, especially iodine, are marketed as an ingredient in products due to their biocidal properties [1,6,14,15]. Iodine is also used to control biohazards in stockpiles of biological weapons [16,17]. Iodine-rich, but thermally stable compounds release I 2 upon deformation to inactivate the microorganisms.…”

Section: I-i-i] − and [I-i•••i]mentioning

confidence: 99%

“…Iodine-rich, but thermally stable compounds release I 2 upon deformation to inactivate the microorganisms. As an element, iodine is not suitable as an ingredient as a defeat agent due to its sublimation [16,17]. The same problem reduces its durability, thermal stability and long-term effectiveness when used in other products as an antimicrobial agent.…”

Section: I-i-i] − and [I-i•••i]mentioning

confidence: 99%

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“Smart” Triiodide Compounds: Does Halogen Bonding Influence Antimicrobial Activities?

et al. 2019

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Antimicrobial agents containing symmetrical triiodides complexes with halogen bonding may release free iodine molecules in a controlled manner. This happens due to interactions with the plasma membrane of microorganisms which lead to changes in the structure of the triiodide anion. To verify this hypothesis, the triiodide complex [Na(12-crown-4)2]I3 was prepared by an optimized one-pot synthesis and tested against 18 clinical isolates, 10 reference strains of pathogens and five antibiotics. The antimicrobial activities of this symmetrical triiodide complex were determined by zone of inhibition plate studies through disc- and agar-well-diffusion methods. The triiodide complex proved to be a broad spectrum microbicidal agent. The biological activities were related to the calculated partition coefficient (octanol/water). The microstructural analysis of SEM and EDS undermined the purity of the triiodide complex. The anionic structure consists of isolated, symmetrical triiodide anions [I-I-I]- with halogen bonding. Computational methods were used to calculate the energy required to release iodine from [I-I-I]- and [I-I···I]-. The halogen bonding in the triiodide ion reduces the antibacterial activities in comparison to the inhibitory actions of pure iodine but increases the long term stability of [Na(12-crown-4)2]I3.

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Section: I-i-i] − and [I-i•••i]mentioning

confidence: 99%

Section: I-i-i] − and [I-i•••i]mentioning

confidence: 99%

“Smart” Triiodide Compounds: Does Halogen Bonding Influence Antimicrobial Activities?

et al. 2019

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“…Coating PGA with antibiotics, therapeutic agents, nanoparticles, and biocidal compounds increases its biological activity, reduces biofilm formation and contamination [25]. Dip-coated PGA can deliver the antimicrobial compounds by controlled drug-release directly on the target tissue [25].Iodine has been used as a biocidal agent in many different applications for a long time [26][27][28][29]. Iodine is used already in wound care but has few disadvantages due to sublimation and skin irritation [26,27,[30][31][32].…”

mentioning

confidence: 99%

“…Iodine has been used as a biocidal agent in many different applications for a long time [26][27][28][29]. Iodine is used already in wound care but has few disadvantages due to sublimation and skin irritation [26,27,[30][31][32].…”

mentioning

confidence: 99%

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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The emergence of resistant pathogens is a burden on mankind and threatens the existence of our species. Natural and plant-derived antimicrobial agents need to be developed in the race against antibiotic resistance. Nanotechnology is a promising approach with a variety of products. Biosynthesized silver nanoparticles (AgNP) have good antimicrobial activity. We prepared AgNPs with trans-cinnamic acid (TCA) and povidone-iodine (PI) with increased antimicrobial activity. We synthesized also AgNPs with natural cinnamon bark extract (Cinn) in combination with PI and coated biodegradable Polyglycolic Acid (PGA) sutures with the new materials separately. These compounds (TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI) and their dip-coated PGA sutures were tested against 10 reference strains of microorganisms and five antibiotics by zone inhibition with disc-and agar-well-diffusion methods. The new compounds TCA-AgNP-PI and Cinn-AgNP-PI are broad spectrum microbicidal agents and therefore potential coating materials for sutures to prevent Surgical Site Infections (SSI). TCA-AgNP-PI inhibits the studied pathogens stronger than Cinn-AgNP-PI in-vitro and on coated sutures. Dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform infrared spectroscopy (FT-IR), Raman, X-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the composition of TCA-AgNP-PI and Cinn-AgNP-PI. Smart solutions involving hybrid materials based on synergistic antimicrobial action have promising future perspectives to combat resistant microorganisms.Pharmaceutics 2020, 12, 361 2 of 36 20,000 related deaths in the United States in 2017 only and remains to be one of the important infection-associated mortality reasons [11,12]. The formation of biofilms on biotic and abiotic surfaces [13] paved the way for biofilm antibiotic tolerance as another major health threat [14,15]. This additional problem hampers the treatment of infections, most often gives rise to chronic infections, in the worst case to therapeutic failure, severe morbidity, and mortality [4]. More than 80% of microbial infections are caused by microbial biofilm formation and pose a severe health risk because treatment with antibiotics remains ineffective [16]. The incidence of chronic wound infections is increasing globally to alarming levels [17]. Chronic wounds are marked by high bacterial colonization and infection rates, which can be treated only by novel therapeutic approaches other than the use of conventional antibiotics [18,19]. Chronic wound tissues can contain microbiomes of complex communities with coexisting fungal and bacterial colonies of different strains within biofilms [20]. According to this inter-kingdom model, fungi like Candida albicans can offer structures for other bacteria (S. aureus, P. aeruginosa, Streptococcus spp., E. faecalis, E. coli, and Acinetobacter baumannii etc.) to attach, form intricate biofilms, and increase the resistance against any ...

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“…Silver nanoparticles have antibacterial and antiviral potential [67][68][69][70]. Iodine is an important antimicrobial agents and has many applications in the medical field [71][72][73][74]. Complexed compounds with iodine offer potential agents with controlled release of iodine from polyiodides against pathogenic microorganisms [75][76][77][78][79][80].…”

Section: Role Of Basic Sciences Against Covid-19 and Antibiotic Resismentioning

confidence: 99%

Prevalence of COVID-19: A Look behind the Scenes from the UAE and India

Bloukh¹,

Shaikh²,

Pathan³

et al. 2020

Preprint

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Mankind faces a coronavirus pandemic originating from a seafood market in Wuhan, China since December 2019. The pathogen was named novel coronavirus (n-CoV) and bats are the identified key reservoir. The coronavirus disease 2019 (COVID-19) quickly spread over China across the globe, turned into a pandemic with exponentially increasing numbers of cases and significant mortality rate. China reacted with lockdowns and strict control measurements to prevent spreading the virus. The treatment of severe cases was hampered by lack of specific vaccines. Vaccine-development and production is a painstaking process and can only be enforced by international cooperation. Different supportive treatment options surfaced due to combinations of antiviral agents with antibiotic drugs. Elderly, male, immune-suppressed patients with co-morbidities showed a high mortality rate. Health literacy, strong immune system, adequate serum 25-hydroxyvitamin D (25(OH)D) concentrations and healthy life style choices can support fast recovery. Antibiotic resistance needs to be addressed by development of new generation antimicrobials against nosocomial infections in preparation for future outbreaks. Plant-biosynthesis of nanomaterials and antiseptics may help in prevention and recovery rate. Prevalence of COVID-19 maybe inversely related to BCG vaccination, endemicity of malaria, humidy and temperature but directly with latitude. Recommendations to prevent the spread of COVID-19 should be followed strictly.

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Control of Biohazards: A High Performance Energetic Polycyclized Iodine-Containing Biocide

Cited by 24 publications

References 19 publications

“Smart” Triiodide Compounds: Does Halogen Bonding Influence Antimicrobial Activities?

“Smart” Triiodide Compounds: Does Halogen Bonding Influence Antimicrobial Activities?

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

Prevalence of COVID-19: A Look behind the Scenes from the UAE and India

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