In order to ensure a high level of performance and to comply with the increasingly severe limitations in terms of fuel consumption and pollution emissions, modern diesel engines need continuous monitoring of their operating conditions by their control units. With particular focus on turbocharged engines, which are presently the standard in a large number of applications, the use of the average and the instantaneous turbocharger speeds is thought to represent a valuable feedback of the engine behavior, especially for the identification of the cylinder-to-cylinder injection variations. The correct operation of the injectors and control of the injected fuel quantity allow the controller to ensure the right combustion process and maintain engine performance. In the present study, two different techniques are presented to fit this scope. The techniques are discussed and experimentally validated, leading to the definition of an integrated control strategy, which features the main benefits of the two, and is able to correctly detect the cylinder-to-cylinder injection variation and, consequently, properly correct the injection in each cylinder in order to balance the engine behavior. In addition, the possibility of detecting misfiring events was assessed.