Controlled delivery of dexamethasone and betamethasone from PLA electrospun fibers: A comparative study

Alves, Priscila Elias; Soares, Bluma G.; Lins, Luanda Chaves; Livi, Sébastien; Santos, Elizabete P.

doi:10.1016/j.eurpolymj.2019.05.001

Cited by 31 publications

(21 citation statements)

References 39 publications

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“…Alves et al. (2019) have reported that incorporation of dexamethasone acetate or betamethasone increased the PLA electrospun fiber diameter (Alves et al., 2019). It was observed that the addition of CA and PAA copolymers reduced the diameter of the fibers.…”

Section: Resultsmentioning

confidence: 99%

“…The aforementioned changes in diameter and surface morphology of fiber cannot be totally related to the changes in viscosity and electrical conductivity of the used mixture (Ozaytekin, 2014). As can be seen (Table 2), incorporation of copolymers led to the same changes in viscosity and electrical conductivity of the mixtures and the viscosity and electrical conductivity of all samples were increased and decreased, respectively (Alves et al, 2019;Priamo et al, 2011;Shi et al, 2012). Figure 4, also indicates that lycopene has not been significantly degraded during the electrospinning process.…”

Section: Scanning Electron Microscopymentioning

confidence: 86%

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Lycopene loaded polylactic acid (PLA) and PLA/copolymer electrospun nanofibers, synthesis, characterization, and control release

Hajikhani

Emam‐Djomeh

Askari

2020

J Food Process Preserv

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The effect of different copolymers on the morphological and encapsulating properties of polylactic acid (PLA) nano(micro)fiber and potential of the fibers for controlling lycopene release rate were studied. The lycopene loaded fibers developed from PLA and different copolymers including polyethylene oxide (PEO), polyacrylic acid, and cellulose acetate (CA) using electrospinning. Diameters and morphology of fabricated fibers are assessed using scanning electron microscopy. Encapsulation of the lycopene in the fibers was confirmed using fluorescence microscopy and Fourier‐transform infrared spectroscopy. Differential scanning calorimetry showed the thermal stability of the encapsulated lycopene. Incorporation of PEO changed the morphology of the fibers and let to fast release of encapsulated lycopene. In presence of CA the fine fiber with surface smooth morphology was produced and the releaase rate of lycopene was decreased which, can be related to good compatibility of PLA and CA that prevent the release of lycopene. Practical applications The use of electrospun ultrafine fibers as drug carriers could be promising in the future for biomedical applications, especially postoperative local chemotherapy and controlled drug release from electrospun fibers has found important biomedical applications in wound healing, transdermal delivery, and tissue engineering. Characterization of forming solution related to properties of produced fibers as well as release properties of embedded functionals are necessary.

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Section: Resultsmentioning

confidence: 99%

Section: Scanning Electron Microscopymentioning

confidence: 86%

Lycopene loaded polylactic acid (PLA) and PLA/copolymer electrospun nanofibers, synthesis, characterization, and control release

Hajikhani

Emam‐Djomeh

Askari

2020

J Food Process Preserv

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“…Electrospun fibers can deliver agents to the target sites, while reducing the toxic side effects of drugs. Electrospun drug carriers improve the effectuality of drug therapy by controlling the rate, and mechanism of release [58,[68][69][70]. Especially, the stimuli-responsive drug delivery systems are promising materials for generating smart wound dressings.…”

Section: Drug Loaded Electrospun Wound Dressingsmentioning

confidence: 99%

“…Lactic acid (2-hydroxypropionic acid, CH3-CHOHCOOH) is the constituent monomer of PLA. Poly (l-lactide) (PLLA), Poly (d-lactide) (PDLA), racemic poly(dl-lactide) (PDLLA) are three isomeric forms of PLA [51,69,161].…”

Section: Application Of Pla-based Electrospun Fibers In Wound Healingmentioning

confidence: 99%

“…Alves et al recently confirmed that PLA electrospun membranes are promising drug delivery systems for sustained release for developing wound dressings [69]. They employed both techniques of physical adsorption and blend electrospinning to load anti-inflammatory agents, dexamethasone acetate (DEX), and betamethasone to PLA electrospun fibers and compare their release efficiency.…”

Section: Application Of Pla-based Electrospun Fibers In Wound Healingmentioning

confidence: 99%

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Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

165

106

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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both synthetic and biologic origin, are gaining increased importance for their high biocompatibility, biodegradation, and bioactive properties, such as antimicrobial, immunomodulatory, cell proliferative, and angiogenic. To create a microenvironment suitable for the healing process, a key property is the ability of a polymer to be spun into submicrometric fibers (e.g., via electrospinning), since they mimic the fibrous extracellular matrix and can support neo- tissue growth. A number of biodegradable polymers used in the biomedical sector comply with the definition of bio-based polymers (known also as biopolymers), which are recently being used in other industrial sectors for reducing the material and energy impact on the environment, as they are derived from renewable biological resources. In this review, after a description of the fundamental concepts of wound healing, with emphasis on advanced wound dressings, the recent developments of bio-based natural and synthetic electrospun structures for efficient wound healing applications are highlighted and discussed. This review aims to improve awareness on the use of bio-based polymers in medical devices.

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Electrospun polylactic acid nanofiber membranes containing Capparis spinosa L. extracts for potential wound dressing applications

Zhu

Zhang

Wang

et al. 2021

J of Applied Polymer Sci

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Capparis spinosa L. (CSL) is a medicinal plant with high antibacterial activity against a variety of pathogens and antioxidation properties. In this paper, for the first time, nanofiber membranes of polylactic acid (PLA) containing 0, 4, 7,and 10 wt% CSL ethyl acetate extract were fabricated by electrospinning. Scanning electron microscopy showed that the fiber diameter decreased after adding CSL to the PLA nanofibers. Fourier transform infrared spectroscopy confirmed that CSL was successfully incorporated in the matrix. The water contact angle test proved that the addition of CSL improved the hydrophilic properties of the material. Moreover, the addition of CSL improved the oxidation resistance of the composite fiber membrane. A burst drug release from the composite nanofibers occurred within the first 12 hr, followed by slow release over a prolonged period of time. As the concentration of CSL increased, the inhibition ability of nanofibers against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) gradually increased. In summary, due to their good mechanical, antioxidant, and antibacterial properties, CSL/PLA nanofiber membranes may possess potential applications as wound dressing materials.

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Controlled delivery of dexamethasone and betamethasone from PLA electrospun fibers: A comparative study

Cited by 31 publications

References 39 publications

Lycopene loaded polylactic acid (PLA) and PLA/copolymer electrospun nanofibers, synthesis, characterization, and control release

Lycopene loaded polylactic acid (PLA) and PLA/copolymer electrospun nanofibers, synthesis, characterization, and control release

Bio-Based Electrospun Fibers for Wound Healing

Electrospun polylactic acid nanofiber membranes containing Capparis spinosa L. extracts for potential wound dressing applications

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