Controlled drug release from contact lenses: a comprehensive review from 1965-present

White, Charles J.; Tieppo, Arianna; Byrne, Mark E.

doi:10.1016/s1773-2247(11)50062-0

Cited by 72 publications

(36 citation statements)

References 59 publications

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“…The cell was designed with a cylindrical inner chamber of 45 µL. This volume is slightly superior to the volume of the tear fluid present in the eye (6.2-30.0 µL) [20][21][22], but, due to operational constraints it could not be smaller.…”

Section: Drug Loading and Drug Releasementioning

confidence: 99%

“…However, they are far from simulating the real release conditions, since they do not match the ocular in vivo flow conditions. In a normal situation, the human eye contains a tear volume that ranges from 6.2 to 30.0 µL [20][21][22] and the tear flow rate assumes values between 0.9 and 2.1 µL/min [23]. The use of contact lenses increases the tear turnover to values of the order 1.4-4.3 µL/min [23].…”

Section: Introductionmentioning

confidence: 99%

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Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

Pimenta

Valente

Pereira

et al. 2016

Drug Deliv. and Transl. Res.

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Currently, most in vitro drug release studies for ophthalmic applications are carried out in static sink conditions. Although this procedure is simple and useful to make comparative studies, it does not describe adequately the drug release kinetics in the eye, considering the small tear volume and flow rates found in vivo.In this work a microfluidic cell was designed and used to mimic the continuous, In conclusion, the use of the microfluidic cell in conjunction with the numerical model shall be a valuable tool to design and optimize new therapeutic drug loaded SCLs.

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Section: Drug Loading and Drug Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

Pimenta

Valente

Pereira

et al. 2016

Drug Deliv. and Transl. Res.

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“…The development of such type of devices has raised great interest among the clinical and academic community and also at the industrial level, as shown by the large number of studies on the subject published in recent years [2,15,16]. Different strategies to load the hydrogels with drugs were attempted, e.g.…”

mentioning

confidence: 99%

About the effect of eye blinking on drug release from pHEMA-based hydrogels: anin vitrostudy

Galante

Paradiso

Moutinho

et al. 2015

Journal of Biomaterials Science, Polymer Edition

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Abstract:The development of new ophthalmic drug delivery systems capable of increasing the residence time of drugs in the eye and improve its bioavailability relatively to eyedrops has been object of intense research in recent years. Several studies have shown that drug loaded therapeutic soft contact lenses (SCLs) constitute a promising approach, with several potential advantages as compared with collyria. The main objective of this work is to study the effect of repetitive load and friction cycles caused by the eye blinking, on the drug release from hydrogels used in SCLs which, as far as we know, was never investigated before. Two poly-2-hydroxyethylmethacrylate based hydrogels, pHEMA-T and pHEMA-UV, were used as model materials. Levofloxaxin was chosen as model drug. The hydrogels were fully characterized in what concerns structural and physicochemical properties. PHEMA-UV revealed some superficial porosity and a lower short range order than PHEMA-T. We observe that the load and friction cycles enhanced the drug release from pHEMA-UV hydrogels. The application of a simple mathematical model, which takes into account the drug dilution caused by the tear flow, showed that the enhancement of the drug release caused by blinking on this hydrogel may be relevant in in vivo conditions. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems CorporationConversely, the more sustained drug release from pHEMA-T is not affected by load and friction cycles. The conclusion is that, depending on the physicochemical and microstructural characteristics of the hydrogels, blinking is a factor that may affect the amount of drug delivered to the eye by SCLs and should thus be considered. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems CorporationAbout the effect of eye blinking on drug release from pHEMA based hydrogels:an in vitro study The development of new ophthalmic drug delivery systems capable of increasing the residence time of drugs in the eye and improve its bioavailability relatively to eyedrops has been object of intense research in recent years. Several studies have shown that drug loaded therapeutic soft contact lenses (SCLs) constitute a promising approach, with several potential advantages as compared with collyria. The main objective of this work is to study the effect of repetitive load and friction cycles caused by the eye blinking, on the drug release from hydrogels used in SCLs which, as far as we know, was never investigated before.Two poly-2-hydroxyethylmethacrylate based hydrogels, pHEMA-T and pHEMA-UV, were used as model materials. Levofloxaxin was chosen as model drug. The hydrogels were fully characterized in what concerns structural and physicochemical properties. PHEMA-UV revealed some superficial porosity and a lower short range order than PHEMA-T.We observe that the load and friction cycles enhanced the drug release from pHEMA-UV hydrogels. The application of a simple mathematical model, which takes into account the drug dilution caused by the tear flow, show...

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“…37 The application of the molecular imprinting technology during soft contact lenses manufacture enables the creation in the lens structure of imprinted pockets and cavities 38 that memorize the spatial features and bonding preferences of the drug and provide the lens with a high affinity for a given drug. Imprinted SCLs could prolong the permanence of the drug in the precorneal area and provide sustained drug levels, increasing ocular bioavailability and avoiding systemic side-effects.…”

Section: Figure 2: Nanoparticle Laden Contact Lens In the Eyementioning

confidence: 99%

Ocular Drug Delivery Role of Contact Lenses

Chauhan¹

2015

DJO

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Controlled drug release from contact lenses: a comprehensive review from 1965-present

Cited by 72 publications

References 59 publications

Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

About the effect of eye blinking on drug release from pHEMA-based hydrogels: anin vitrostudy

Ocular Drug Delivery Role of Contact Lenses

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