Controlled fabrication of drug‐loaded protein nanoparticles via flash nanoprecipitation

Zhao, Hongyang; Wang, Mingwei; Wang, Xinming; Wang, Zhibin; Xing, Mengyuan; Huang, Haiyan; Stuart, Martien A. Cohen; Wang, Junyou

doi:10.1002/aic.17941

Cited by 5 publications

(5 citation statements)

References 42 publications

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“…As shown in Figure e, abamectin showed several characteristic peaks at 2964, 1735, and 1047 cm –1 . These typical peaks were weakened or even disappeared in the spectra of the ABM@BSA-FITC/GA NPs, which was mainly due to the generation of hydrophobic interaction and hydrogen bonding between abamectin and BSA-FITC, thus restricting the vibrations of the abamectin molecules . In addition, the ABM@BSA-FITC/GA NPs revealed the emergence of a new peak at 1051 cm –1 , which corresponded to the characteristic peak of GA.…”

Section: Resultsmentioning

confidence: 93%

“…39 These typical peaks were weakened or even disappeared in the spectra of the ABM@BSA-FITC/GA NPs, which was mainly due to the generation of hydrophobic interaction and hydrogen bonding between abamectin and BSA-FITC, thus restricting the vibrations of the abamectin molecules. 40 In addition, the ABM@BSA-FITC/GA NPs revealed the emergence of a new peak at 1051 cm −1 , which corresponded to the characteristic peak of GA. The crystal structures of abamectin, FITC, BSA, BSA-FITC, GA, and ABM@BSA-FITC/GA NPs were studied by XRD (Figure 1f).…”

Section: ■ Results and Discussionmentioning

confidence: 96%

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Smart Protein-Based Fluorescent Nanoparticles Prepared by a Continuous Nanoprecipitation Method for Pesticides’ Precise Delivery and Tracing

Chen

et al. 2023

J. Agric. Food Chem.

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It is highly desirable to develop smart and green pesticide nanoformulations for improving pesticide targeting and reducing their inherent toxicity. Herein, we demonstrate a continuous nanoprecipitation method to construct a novel type of enzyme-responsive fluorescent nanopesticides (denoted as ABM@BSA-FITC/GA NPs) based on abamectin, fluorescein isothiocyanate isomer (FITC)-modified protein, and food-grade gum arabic. The as-prepared ABM@BSA-FITC/GA NPs exhibit good water dispersibility, excellent storage stability, and enhanced wettability compared to commercial formulations. The controlled release of pesticides can be achieved through protein degradation caused by trypsin. Most importantly, the deposition, distribution, and transport of the ABM@BSA-FITC/GA NPs are precisely tracked on target plants (cabbage and cucumber) by fluorescence. Furthermore, the ABM@BSA-FITC/GA NPs show the high control efficacy against Plutella xylostella L., which is comparable with commercial emulsifiable concentrate formulation. In consideration of its eco-friendly composition and absence of organic solvent, this pesticide nanoformulation has promising potential in sustainable plant protection.

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Section: Resultsmentioning

confidence: 93%

Section: ■ Results and Discussionmentioning

confidence: 96%

Smart Protein-Based Fluorescent Nanoparticles Prepared by a Continuous Nanoprecipitation Method for Pesticides’ Precise Delivery and Tracing

Chen

et al. 2023

J. Agric. Food Chem.

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“…Regulating the flow regime in the microfluidic device is also an effective approach for constructing a restricted region. 10 Droplets and phase interface flow regimes formed by the two-phase fluids allow the crystallization process conducted in the designated zone. 11 Luo et al, 12 described a two-stage microfluidic method to prepare the MgAl 2 O 4 -supported Rh nanocatalysts with high loading and uniform crystal morphology in a membrane dispersion microreactor based on droplets flow regime.…”

Section: Introductionmentioning

confidence: 99%

“…This strategy provides an available way for the regulation of ACC crystallization, resulting in a uniform morphology of ACC. Regulating the flow regime in the microfluidic device is also an effective approach for constructing a restricted region 10 . Droplets and phase interface flow regimes formed by the two‐phase fluids allow the crystallization process conducted in the designated zone 11 .…”

Section: Introductionmentioning

confidence: 99%

Hollow fiber membrane governed microjet flow regime for confined crystallization of large‐sized crystal aggregates

Niu,

Du,

Liang

et al. 2024

AIChE Journal

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Confined crystallization can realize controllable nucleation and growth of crystals with targeted morphologies in a restricted region. Here, we achieved confined reactive crystallization within a novel micro columnar jet flow regime constructed by the hollow fiber membrane. The interface of the jet flow corresponds as the restricted region for reactive crystallization, and the large‐sized calcium carbonate (CaCO3) crystals aggregates with millimeter length can ordered and self‐assembly grow along the boundary of this region. Formation mechanism of the jet flow was systematically investigated by real‐time observation and force analysis. The detected detachment‐regrowth cycle during the experiments furtherly uncovered the potential for continuous operation. Linear (diameter: 0.12–0.3 mm; length: 1.5–3.1 mm) and lamellar crystals (thickness of 200–300 nm and average area of 0.21 mm2) were obtained by effectively manipulating the diameter and effective length of jet flow.

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“…Antisolvent precipitation (e.g., nanoprecipitation 1 ) is the most widely used bottom‐up method for the synthesis of micro‐ and nano‐sized active pharmaceutical ingredients (APIs) 2 and drug delivery systems 3 . Basically, antisolvent precipitation is carried out by mixing a solvent with antisolvent to generate supersaturation, followed by fast particle nucleation and growth.…”

Section: Introductionmentioning

confidence: 99%

Cavitation behavior and mixing performance of antisolvent precipitation process in an ultrasonic micromixer

et al. 2023

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A facile and robust ultrasonic micromixer was developed to intensify antisolvent precipitation via ultrasonic cavitation. The gas supersaturation created from solventantisolvent mixing was found to be a novel driving force which facilitated the generation of cavitation bubbles (CBs). Instead of being attached on the channel wall, numerous CBs translated across the microchannel at a speed up to 1.7 m/s, inducing intense transverse flow over the cross-section. The unique cavitation behavior enabled rapid mixing (mixing time 15-45 ms at 30 W) of solvent-antisolvent over wide Reynolds number range (70-500) and flow rate ratio (5:1-2:3), providing better operability for antisolvent precipitation. The effects of ultrasonic power, total flow rate, flow rate ratio, and solvent on cavitation behavior and mixing performance were quantitatively studied. Finally, the potential of the ultrasonic micromixer as a new tool for antisolvent precipitation was demonstrated by synthesizing size-controllable and monodisperse polymeric nanoparticles in a high-throughput and reproducible manner.

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Controlled fabrication of drug‐loaded protein nanoparticles via flash nanoprecipitation

Cited by 5 publications

References 42 publications

Smart Protein-Based Fluorescent Nanoparticles Prepared by a Continuous Nanoprecipitation Method for Pesticides’ Precise Delivery and Tracing

Smart Protein-Based Fluorescent Nanoparticles Prepared by a Continuous Nanoprecipitation Method for Pesticides’ Precise Delivery and Tracing

Hollow fiber membrane governed microjet flow regime for confined crystallization of large‐sized crystal aggregates

Cavitation behavior and mixing performance of antisolvent precipitation process in an ultrasonic micromixer

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