Controlled release of chlorhexidine antiseptic from microporous amorphous silica applied in open porosity of an implant surface

Verraedt, Els; Braem, Annabel; Chaudhari, Amol; Thevissen, Karin; Adams, Erwin; Mellaert, Lieve Van; Cammue, Bruno P. A.; Duyck, Joke; Anné, Jozef; Zhang, Fei; Martens, Johan A.

doi:10.1016/j.ijpharm.2011.06.053

Cited by 18 publications

(17 citation statements)

References 22 publications

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“…For in vivo implant applications, this might be more favorable, although this phase can be passed through before implantation if lower release concentrations are desired. These results differentiate the current work from previous studies which are predominantly characterized by either a burst release or premature depletion of the compound [18,[27][28][29].…”

Section: Discussioncontrasting

confidence: 57%

“…For example, porous titanium (Ti) or stainless steel cylinders have been described to serve as a reservoir for drug loaded gelatin sponges or packed beds of mesoporous silica particles, respectively [26][27][28]. Moreover, we have previously synthesized amorphous microporous silica inside an open porous Ti surface coating for the controlled release of chlorhexidine [29]. This inspired us to the idea of incorporating a mesoporous diffusion barrier, consisting of SiO 2 , in a bulk porous Ti implant material for the controlled release of a therapeutic compound from an internal reservoir.…”

Section: Introductionmentioning

confidence: 99%

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Novel anti-infective implant substrates: Controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium

Braem

Cremer

Delattin

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Novel anti-infective implant substrates: Controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium

Braem

Cremer

Delattin

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…The long‐term bond strength of MMPs' effects was not evaluated. Future studies must be carried out using MMPs, such as CHX, in controlled‐release mechanisms, as used in endodontic, periodontal, and implant therapy …”

Section: Future Researchmentioning

confidence: 99%

Dentin Adhesion and MMPs: A Comprehensive Review

Perdigão

Reis

Loguércio

2013

J Esthet Restor Dent

184

160

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This review examines the fundamental processes responsible for the aging mechanisms involved in the degradation of resin-bonded interfaces, as well as some potential approaches to prevent and counteract this degradation. Current research in several research centers aims at increasing the resin-dentin bond durability. The hydrophilic and acidic characteristics of current dentin adhesives have made hybrid layers highly prone to water sorption. This, in turn, causes polymer degradation and results in decreased resin-dentin bond strength over time. These unstable polymers inside the hybrid layer may result in denuded collagen fibers, which become vulnerable to mechanical and hydrolytical fatigue, as well as degradation by host-derived proteases with collagenolytic activity. These enzymes, such as matrix metalloproteinases and cysteine cathepsins, have a crucial role in the degradation of type I collagen, the organic component of the hybrid layer. This review will also describe several methods that have been recently advocated to silent the activity of these endogenous proteases.

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“…It does not display adverse effects on the survival and proliferation of human mesenchymal stem cells (Verraedt et al. ). Moreover, the bone regeneration around AMS‐coated titanium implants has been reported to be similar to the one happening around the titanium implants (Chaudhari et al.…”

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confidence: 99%