Controlled Release of Chlorhexidine from UDMA-TEGDMA Resin

Abstract

Chlorhexidine salts are available in various formulations for dental applications. This study tested the hypothesis that the release of chlorhexidine from a urethane dimethacrylate and triethylene glycol dimethacrylate resin system can be effectively controlled by the chlorhexidine diacetate content and pH. The filler concentrations were 9.1, 23.1, or 33.3 wt%, and the filled resins were exposed to pH 4 and pH 6 acetate buffers. The results showed that Fickian diffusion was the dominant release mechanism. The rates of release were significantly higher in pH 4 buffer, which was attributed to the increase of chlorhexidine diacetate solubility at lower pH. The higher level of filler loading reduced the degree of polymerization, leading to a greater loss of organic components and higher chlorhexidine release rates.

Chlorhexidine release and water sorption characteristics of chlorhexidine-incorporated hydrophobic/hydrophilic resins

“…When high loads (9-33 wt%) of CDA were added to 70 wt% UDMA/30% TEGDMA resin systems the undissolved CDA acted as fillers [21]. Higher filler loadings was found to reduce the degree of polymerisation, increase the dissolution of organic components, and resulted in faster chlorhexidine release rates [21]. In the current study, CDA powder was dissolved in the neat blends before polymerization.…”

“…Clinically acceptable polymerisation rates was achieved by the addition of UDMA and TEGDMA, with increased cross-linking of the comonomers and suppressed water sorption-induced swelling that resulted in controlled chlorhexidine release for extended time periods. When high loads (9-33 wt%) of CDA were added to 70 wt% UDMA/30% TEGDMA resin systems the undissolved CDA acted as fillers [21]. Higher filler loadings was found to reduce the degree of polymerisation, increase the dissolution of organic components, and resulted in faster chlorhexidine release rates [21].…”

“…Experimental chlorhexidine-incorporated resin blends were prepared by adding CDA (Sigma-Aldrich, St. Louis, MO, USA) to the neat comonomer blends, according to the method described by Anusavice et al [21]. Four groups chlorhexidine-incorporated resins were created from each neat resin blend by directly adding 0.0 wt%.…”

Characterization of chlorhexidine-releasing, fast-setting, brushite bone cements

“…Corsodyl TM ). It has also been incorporated within various dental restorative materials to reduce recurrent caries [16,17] and is used in antiseptic creams and sprays (e.g. Savlon TM ).…”

Influence of 2% chlorhexidine on pH, calcium release and setting time of a resinous MTA-based root-end filling material

“…It has been observed that the cationic properties of CHX interfere with the setting mechanisms of glass ionomer cements 26 and resins. 27 Moreover, Kogan et al 28 showed that MTA mixed with CHX gel did not set until the end of a 4-hour observation period.…”