Controlled release of dual drugs from emulsion electrospun nanofibrous mats

Su, Yan; Li, Xiaoqiang; Liu, Shuiping; Mo, Xiumei; Ramakrishna, Seeram

doi:10.1016/j.colsurfb.2009.06.009

Cited by 118 publications

(51 citation statements)

References 23 publications

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“…It indicated that the electrospun fibrous membranes were expected to carry dual hydrophilic and/or hydrophobic drugs and proteins for biomedical applications or pharmaceutical devices [49].…”

Section: Drug Delivery Vehiclesmentioning

confidence: 99%

Core-shell Fibers for Biomedical Applications-A Review

Elahi¹,

Wang²,

Guan³

et al. 2013

J Bioeng Biomed Sci

111

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Now is the age of high-tech research and development. Different types of fibers have been produced in the last decades for the benefit of human needs. Core-shell nanofibers are a revolutionary development in the field of science and technology. Preparation of nanoscale fibers in a core-shell configuration, using two dissimilar materials, via a novel technique of electrospinning has presented unusual potential for use in many novel applications. The studies have addressed issues related to the technology involved and examined the suitability of the technique for producing unique nanoscale morphologies involving variety of materials. Numerous studies have been published on the preparation of core-shell nanofibers by electrospinning process for developing novel structures for new applications. No major review of the co-axial electrospinning process has appeared to the knowledge of the authors but is needed in order to develop a fuller understanding of the status of work in this field. After a brief introduction to the conventional electrospinning process, this paper focuses on the preparation and uses of core-shell fibers by electrospinning studies published to date. It attempts to categorize them in terms of the approaches adopted, and highlights the knowledge gained with respect to the material and process parameters that impact the size and the uniformity of the core-shell nanofibers obtained.

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Section: Drug Delivery Vehiclesmentioning

confidence: 99%

Core-shell Fibers for Biomedical Applications-A Review

Elahi¹,

Wang²,

Guan³

et al. 2013

J Bioeng Biomed Sci

111

View full text Add to dashboard Cite

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“…10,11 These problems could be overcome by development of a novel combined therapy to improve the bioavailability of antioxidant and hypoglycemic drugs via a transdermal delivery system. 12,13 A transdermal delivery system is an appropriate route for administration of free radical scavengers because skin is an important target candidate for oxidative stress and the combined therapy can be good as an antidote to reduce secondary damage. 5,6 Most importantly, a transdermal drugdelivery system can prevent first-pass metabolism, enabling high bioavailability of drugs and enhance patient compliance, with fewer doses needed and minimal toxicity.…”

Section: Introductionmentioning

confidence: 99%

Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery

Bennet¹,

Marimuthu²,

Kim³

et al. 2012

IJN

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Antioxidant (quercetin) and hypoglycemic (voglibose) drug-loaded poly-D,L-lactideco-glycolide nanoparticles were successfully synthesized using the solvent evaporation method. The dual drug-loaded nanoparticles were incorporated into a scaffold film using a solvent casting method, creating a controlled transdermal drug-delivery system. Key features of the film formulation were achieved utilizing several ratios of excipients, including polyvinyl alcohol, polyethylene glycol, hyaluronic acid, xylitol, and alginate. The scaffold film showed superior encapsulation capability and swelling properties, with various potential applications, eg, the treatment of diabetes-associated complications. Structural and light scattering characterization confirmed a spherical shape and a mean particle size distribution of 41.3 nm for nanoparticles in the scaffold film. Spectroscopy revealed a stable polymer structure before and after encapsulation. The thermoresponsive swelling properties of the film were evaluated according to temperature and pH. Scaffold films incorporating dual drug-loaded nanoparticles showed remarkably high thermoresponsivity, cell compatibility, and ex vivo drug-release behavior. In addition, the hybrid film formulation showed enhanced cell adhesion and proliferation. These dual drugloaded nanoparticles incorporated into a scaffold film may be promising for development into a transdermal drug-delivery system.

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“…The addition of KET thus decreases the fiber diameters, as a result of the solutions having increased conductivity when the drug is added [28]. This can extend the elongation of the polymer jet and thereby generate narrower fibers.…”

Section: Fiber Productionmentioning

confidence: 99%

A thermosensitive drug delivery system prepared by blend electrospinning

Liu

Sang

et al. 2017

Colloids and Surfaces B: Biointerfaces

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A thermosensitive drug delivery system prepared by blend electrospinning, Colloids and Surfaces B: Biointerfaceshttp://dx.doi.org/10. 1016/j.colsurfb.2017.07.058 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.  5. PDEGMA/EC fibers were found to have good biocompatibility towards fibroblasts. Abstract:2 In this study, the thermosensitive polymer poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) was synthesized and electrospun into fibers by blending with ethyl cellulose (EC). Fibers were additionally prepared loaded with ketoprofen (KET) as a model drug. Smooth cylindrical fibers could generally be observed by electron microscopy, although there were some beads and fused fibers visible in the KET-loaded materials. KET was found to be amorphously distributed in the fibers on the basis of X-ray diffraction data. From water contact angle measurements, it was clear that the wettability of the EC/PDEGMA fibers changed as the temperature increased, with the fibers becoming markedly more hydrophobic. In vitro drug release studies showed that KET was released over a prolonged period of time with the fibers having different release profiles at 25 and 37 ºC, reflecting their thermosensitive properties.Furthermore, the materials were found to have good biocompatibility towards L929fibroblasts. Thus, the fibers prepared in this work have potential as smart stimuliresponsive drug delivery systems.

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Controlled release of dual drugs from emulsion electrospun nanofibrous mats

Cited by 118 publications

References 23 publications

Core-shell Fibers for Biomedical Applications-A Review

Core-shell Fibers for Biomedical Applications-A Review

Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery

A thermosensitive drug delivery system prepared by blend electrospinning

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