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Chitosan-poly(L-lactic acid-co-epsilon-caprolactone)(50:50) (P(LLA-CL)) (CS/P(LLA-CL)) blends were electrospun into nanofibers using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) and trifluoroacetic acid (TFA) as solvents. Chitosan, which is difficult to electrospin into nanofibers, could be easily electrospun into nanofibers with addition of a small portion of P(LLA-CL). The fiber diameter depended on both the polymer concentration and the blend ratio of chitosan to P(LLA-CL). The average fiber diameter increased with increasing polymer concentration and decreasing the blend ratio of chitosan to P(LLA-CL). X-ray diffractometry (XRD) and Fourier-transform infrared (FT-IR) spectra were measured to characterize blended nanofibers. The porosity of CS/P(LLA-CL) nanofiber mats increased with increasing the weight ratio of chitosan to P(LLA-CL), while both the tensile strength and the ultimate strain increased with increasing P(LLA-CL) ratio. Fibroblast cell growth on nanofiber mats were investigated with MTT assay and scanning electron microscope (SEM) observation. The highest cell proliferation was observed on the nanofiber mats when the weight ratio of chitosan to P(LLA-CL) was 1:2. As SEM images shown, fibroblast cells showed a polygonal shape on blend nanofiber mats and migrated into the nanofiber mats.

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Poly(L-lactide acid)-blend-gelatin (PLLAgelatin) nanofibers were successfully fabricated by means of electrospinning. The different material components characterizing the properties of electrospun PLLA/G nanofibers were measured and the effect of PLLA weight ratios on such properties as morphologies, physical and chemical structure and mechanical profiles were analyzed. It was found that the fibers diameter increases and the ultimate tension-stress enhances with increased PLLA weight ratio. The analysis of X-ray diffractometry, differential scanning calorimetry, and Fourier-transform infrared spectra demonstrated that the resultant nanofibers from electrospinning of PLLA-gelatin solution are simple blends of these two components.

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