Controlled release of ketoprofen from electrospun poly(vinyl alcohol) nanofibers

Kenawy, El‐Refaie; Abdel-Hay, F. I.; El‐Newehy, Mohamed H.; Wnek, Gary E.

doi:10.1016/j.msea.2007.01.039

Cited by 173 publications

(113 citation statements)

References 33 publications

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“…PVAs of high molecular weight were applied earlier in electrospinning for controlling and sustaining drug release through gel formation [31]. However, in this work the instant dissolution was the aim therefore PVA of low molecular weight (31 000 Da) was selected having moderate tendency for gel formation.…”

Section: Drug Dissolution Investigationmentioning

confidence: 99%

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Nagy¹,

Nyúl²,

Wagner³

et al. 2010

Express Polym. Lett.

121

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Abstract. Electrostatic spinning (Electrospinning, ES) was applied to prepare Donepezil HCl loaded nanofibers as a potential orally dissolving dosage form. Electrospinning of water solutions of different polymers were performed in order to fabricate a consistent and removable web on the collector with ultra-fast dissolution in water based media. Poly(vinyl-alcohol) of low molecular weight was found to be the most appropriate for this purpose. Morphology of the prepared nanofibers was characterized by scanning electron microscope as a function of viscosity and drug content. Diameters of the fibers were between 100 and 300 nm with narrow distribution. In vitro drug release of the webs was immediate (less than 30 s) after immersion independently of their drug content owing to the formed huge surface area, while cast films with the same compositions and commercial tablets needed 30 min or more for complete dissolution. The developed technology for the preparation of orally dissolving web (ODW) formulations is a promising way for producing effective and acceptable dosage forms for children, older people and patients with dysphagia.

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Section: Drug Dissolution Investigationmentioning

confidence: 99%

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Nagy¹,

Nyúl²,

Wagner³

et al. 2010

Express Polym. Lett.

121

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“…PVA electrospun fibrous membranes with well-controlled uniform nanosized fiber diameter have been tested for a ethanol, [7,10] acetone, [9] and methanol [8] have been used. This process is extremely slow requiring 3-48 h. This would pose an efficiency problem for a scale-up production with the required volume of solvent and amount of time.…”

Section: Introductionmentioning

confidence: 99%

Functional Cross‐Linked Electrospun Polyvinyl Alcohol Membranes and Their Potential Applications

Truong

Choi

Mardel

et al. 2017

Macro Materials & Eng

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range of applications. [1][2][3] It is a suitable polymer for the novice electrospinning to produce nanofibers as it is inexpensive, nontoxic, and water soluble. However, due to its water solubility, it needs to be stabilized, for example, by cross-linking to enable its practical application in waterbased environments to be realized. There are several studies demonstrating cross-linking of electrospun PVA membranes and their water stabilization. [4][5][6][7][8][9] Three major cross-linking methods have been described in the literature but each of these methods has its own problems in scaling up and cross-linking efficiency.(i) Immersion of electrospun membranes into an organic solvent (ii) Exposure of electrospun membranes to reagent vapor (iii) Addition of a cross-linker/catalyst to electrospinning solutionsThe first approach involving the use of an organic solvent is the simplest approach. Solvents such as Polyvinyl alcohol (PVA) is a water soluble polymer that requires further treatment to be stabilized before it can be used in aqueous environments. Electrospun PVA is cross-linked by incorporating cross-linking agents directly into the electrospinning solution followed by post-electrospinning thermal treatments to attain stability in aqueous environments. Previously published works on post-treatments include glutaraldehyde vapor exposure or soaking in organic solvents such as ethanol. However, these treatments incur lots of difficulties and hazards especially in scale production. In this study, with a view of imminent scale-up production required, fabricating electrospun cross-linked PVA is investigated without using catalysts, toxic vapor exposure, or solvent treatment. To produce cross-linked electrospun PVA membranes, citric acid, maleic acid, and polyacrylic acid are, respectively, added to PVA solution prior to electrospinning. Two potential applications are examined; the first is to use the membranes as produced for metal uptake in aqueous systems. The second application is for ammonia adsorption after decorating the membranes with a metal organic framework, copper benzene-1,3,5-tricarboxylate (HKUST-1).

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“…[13][14][15][16][17][18][19][20][21] The very fine diameter and high porous structure of nanofiber mats help drug particles diffuse out of the matrix more efficiently. 14,15 The most popular, preferred, and inexpensive technique for fabricating polymeric nanofibers is electrospinning.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Poly(vinyl alcohol) (PVA) is a well-known, biologically friendly, biodegradable polymer owing to its desirable properties such as nontoxicity, no carcinogenicity, biocompatibility, and appropriate mechanical properties. 1,2,7,18 Because of these properties, PVA is used in some biomedical applications such as soft contact lenses, implants of artificial organs, cartilage skin, and cardiovascular devices. 2,18 Because of its flexibility and swelling capability in an aqueous medium, PVA has been much studied as a wound dressing; 2 however, its poor stability in water has limited its use in aqueous systems, particularly for drug-delivery applications.…”

Section: Introductionmentioning

confidence: 99%

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Jannesari¹,

Varshosaz²,

Morshed³

et al. 2011

IJN

141

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The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol) (PVA), poly(vinyl acetate) (PVAc), and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl), were successfully prepared by an electrospinning technique for the first time. The morphology and average diameter of the electrospun nanofibers were investigated by scanning electron microscopy. X-ray diffraction studies indicated an amorphous distribution of the drug inside the nanofiber blend. Introducing the drug into polymeric solutions significantly decreased solution viscosities as well as nanofiber diameter. In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release. Blending PVA and PVAc exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications. Also, the thickness of the blend nanofiber mats strongly influenced the initial release and rate of drug release.

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Controlled release of ketoprofen from electrospun poly(vinyl alcohol) nanofibers

Cited by 173 publications

References 33 publications

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Functional Cross‐Linked Electrospun Polyvinyl Alcohol Membranes and Their Potential Applications

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

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