Controlling drug release from mesoporous silica through an amorphous, nanoconfined 1-tetradecanol layer

Mitran, Raul−Augustin; Matei, Cristian; Berger, Daniela; Băjenaru, Laura; Moisescu, Mihaela G.

doi:10.1016/j.ejpb.2018.02.020

Cited by 26 publications

(10 citation statements)

References 38 publications

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“…Silica produced from RH at a temperature of 500 to 650°C with a combustion time of 2.5 to 6 h is predominantly amorphous, while crystallinity is achieved when the annealing temperature rises above 700°C. While crystalline silica is used in ceramics, steel, thermal insulator and refractory bricks (Prasad et al, 2001) and in the concrete industry (Kumar et al, 2013), amorphous silica finds a much wider range of applications in concrete production (Kannan, 2018), pulp industry (Chen et al, 2017), laboratory glassware (Shi et al, 2017), adsorbents (Pivovarov, 2008) and drag delivery carriers (Mitran et al, 2018). Various value-added products, such as aerogel (Tang and Wang, 2005), silica carbide (Niyomwas, 2009), porous carbon (Satayeva et al, 2018), zeolites (Ng et al, 2015) and other products can be obtained by using the silica produced from RH (Shen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Sustainable production of pure silica from rice husk waste in Kazakhstan

Azat

Korobeinyk

Μουστάκας

et al. 2019

Journal of Cleaner Production

173

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Section: Introductionmentioning

confidence: 99%

Sustainable production of pure silica from rice husk waste in Kazakhstan

Azat

Korobeinyk

Μουστάκας

et al. 2019

Journal of Cleaner Production

173

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show abstract

“…Details of the extraction methodology, effect of process pretreatment on the quality of the silica product, effect of post-processing steps, and environmental aspect of the silica extraction methodologies have been reported by several groups of authors [29][30][31][32][33][34][35][36][37][38][39][40][41][42]. Amorphous silica is mostly consumed as laboratory glass ware [43], in paper and pulp industry [44], drag delivery carriers [45], while crystalline silica typically find uses in ceramics, steel, thermal insulator, and refractory bricks [47] and in the concrete industry [46], but its processing is not completely eco-friendly in nature because of its acid and alkali residues [48]. The preparation of bioactive glass ceramics based on isolated silica for drug delivery system has been reported by Chen et al [44].…”

Section: Potential Resources Of Agricultural Waste To Be Used As Glasmentioning

confidence: 99%

Development of Glass Ceramics from Agricultural Wastes

Das¹,

Bhattacharjee²

2020

Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications

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Glass and ceramics have become an indispensable part of mankind, starting from home appliances to construction materials. Some common home appliance applications include the finest tableware, cook wares, and even many washing machines and driers. Glass ceramics are smart materials combining the properties of glass with the benefits of conventional sintered ceramics. "Glass ceramics" refers to a material that consists of one/more glass phases with one/more crystalline phases. These materials are typically manufactured, in a controlled nucleation and crystallization of any base glass. In brief, glass ceramic structure comprises an amorphous (glassy) phase with one/multiple embedded crystalline phases. The compositional variation of glass ceramics may design products of highly crystalline to more substantial glassy phase or transparent to opaque materials. To meet the specific requirements, compositional difference may be tuned to have material with zero thermal expansion, high toughness, resistance to thermal shock, and high impact resistance. According to the typical convention of base material, glass ceramics may be of either oxide based (silicate (SiO 2), borate (B 2 O 3), phosphate (P 2 O 5), and germinate (GeO 2)) or non-oxide based (chalcogenide, halide, and metallic). With wide variation of thermal and mechanical characteristics, glass has a broad range of applications like cooktops, toasters, clothes

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“…An efficient modification route is silylation with trimethylchlorosilane (TMCS) [18] for this purpose. Several studies focus on the immediate release of poorly water-soluble drugs [20][21][22], but achieving the controlled release of highly water-soluble, hydrophilic APIs [23][24][25]-by using surface-modified MPS-as a carrier is a less studied area.…”

Section: Introductionmentioning

confidence: 99%

Development of a Hydrophobicity-Controlled Delivery System Containing Levodopa Methyl Ester Hydrochloride Loaded into a Mesoporous Silica

et al. 2021

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Background: The drug release of antiparkinsonian drugs is an important issue during the formulation process because proper release kinetics can help to reduce the off periods of Parkinson’s disease. A 2-factor, 3-level (32) full-factorial design was conducted to evaluate statistically the influence of the hydrophobicity of mesoporous silica on drug release. Methods: Hydrophobization was evaluated by different methods, such as contact angle measurement, infrared spectroscopy and charge titration. After loading the drug (levodopa methyl ester hydrochloride, melevodopa hydrochloride, LDME) into the mesopores, drug content, particle size, specific surface area and homogeneity of the products were also analyzed. The amorphous state of LDME was verified by X-ray diffractometry and differential scanning calorimetry. Results: Drug release was characterized by a model-independent method using the so-called initial release rate parameter, as detailed in the article. The adaptability of this method was verified; the model fitted closely to the actual release results according to the similarity factor, independently of the release kinetics. Conclusions: The API was successfully loaded into the silica, resulting in a reduced surface area. The release studies indicated that the release rate significantly decreased (p < 0.05) with increasing hydrophobicity. The products with controlled release can reduce the off period frequency.

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Controlling drug release from mesoporous silica through an amorphous, nanoconfined 1-tetradecanol layer

Cited by 26 publications

References 38 publications

Sustainable production of pure silica from rice husk waste in Kazakhstan

Sustainable production of pure silica from rice husk waste in Kazakhstan

Development of Glass Ceramics from Agricultural Wastes

Development of a Hydrophobicity-Controlled Delivery System Containing Levodopa Methyl Ester Hydrochloride Loaded into a Mesoporous Silica

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