Controlling molecular orientations of hydrogels in oil–drug@hydrogel particle delivery systems for pH-selective/sustained release and stabilization of bioactive drugs

Song, Ji Eun; Lim, Sora; Kim, Do Hoon; Cho, Eun Chul

doi:10.1016/j.colsurfa.2015.11.032

Cited by 5 publications

(2 citation statements)

References 59 publications

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“…On the one hand, there are many relevant utility patents, including preparation and purity technology of arbutin in actual industrial production, 8 whitening product formula containing arbutin, 9 etc. On the other hand, because of its hydrophilic nature and a faster rate of dissolution that influence the release as a drug in the body, many scholars have attempted to improve its transfer process, like using polymeric nanoparticles 10 or oil-drug@molecularly oriented hydrogel shells particles, 11 and so on.…”

mentioning

confidence: 99%

Solubility and Data Correlation of β-Arbutin in Different Monosolvents from 283.15 to 323.15 K

Liu

Wan

et al. 2019

J. Chem. Eng. Data

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The solubility of β-arbutin (ARB) in 12 different monosolvents (methanol, ethanol, propanol, isopropanol, butyl alcohol, isobutanol, ethyleneglycol, acetone, 2-butanone, acetonitrile, methyl acetate, and ethyl acetate) from 283.15 to 323.15 K at atmospheric pressure was measured by gravimetric method. The solubility data show an increasing trend with increasing temperature. The solubility is related to many factors like polarity, H-bond, cohesive energy density, etc. The solubility of ARB was correlated by the Apelblat model, λh model, Van’t Hoff equation, and nonrandom two-liquid (NRTL) model. Also, the Apelblat model shows a better fitting result compared with other three models through calculating the value of ARD. Besides, the dissolution thermodynamic properties (the dissolution Gibbs energy, enthalpy, and entropy) were evaluated, which revealed that the dissolution of ARB was a spontaneous and exothermic process.

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confidence: 99%

Solubility and Data Correlation of β-Arbutin in Different Monosolvents from 283.15 to 323.15 K

Liu

Wan

et al. 2019

J. Chem. Eng. Data

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“…The combination of CCC gels with other pH-responsive microcapsules , would be useful for the production of controlled release bioactive drugs. Song et al prepared oil core particles with hydrogel shells consisting of alginate or Curdlan bonded with calcium ions, which is similar to artificial salmon roe. Although this case deals with a drug in oil, particles with Curdlan hydrogel shells displayed pH-tolerant sustained drug release and effectively protected the unstable bioactive drug from its denaturation.…”

Section: Resultsmentioning

confidence: 99%

Volume Phase Transition of Chemically Cross-linked Curdlan Hydrogels Dependent on pH

Itagaki

Koshino

Ito

et al. 2016

ACS Biomater. Sci. Eng.

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Curdlan is a polysaccharide that is expected to work as a gene carrier. We synthesized chemically cross-linked Curdlan (CCC) gel and examined its characterization. CCC gels were swollen with alkaline water over pH ∼10.2, but shrunk with acid and neutral water. Swelling ratios of the present CCC gels with water were found to be 45 times at the most and dependent on the fraction of cross-linker reagent. These volume phase transition gels that are sensitive to pH are useful and ecological as a biocompatible and biodegradable material.

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Versatile Multi-Network Hydrogel of Acrylamide, Sodium Vinyl Sulfonate, and N,N′-Methylene Bisacrylamide: A Sustainable Solution for Paracetamol Removal and Swelling Behavior

et al. 2023

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Controlling molecular orientations of hydrogels in oil–drug@hydrogel particle delivery systems for pH-selective/sustained release and stabilization of bioactive drugs

Cited by 5 publications

References 59 publications

Solubility and Data Correlation of β-Arbutin in Different Monosolvents from 283.15 to 323.15 K

Solubility and Data Correlation of β-Arbutin in Different Monosolvents from 283.15 to 323.15 K

Volume Phase Transition of Chemically Cross-linked Curdlan Hydrogels Dependent on pH

Versatile Multi-Network Hydrogel of Acrylamide, Sodium Vinyl Sulfonate, and N,N′-Methylene Bisacrylamide: A Sustainable Solution for Paracetamol Removal and Swelling Behavior

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