Convenient detection of metal–DNA, metal–RNA, and metal–protein adducts with a click-modified Pt(<scp>ii</scp>) complex

Moghaddam, Alan D.; White, J. D.; Cunningham, Rachael M.; Loes, Andrea N; Haley, Michael M.; DeRose, Victoria J.

doi:10.1039/c4dt02649g

Cited by 23 publications

(31 citation statements)

References 28 publications

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“…Several examples of covalent binding of platinum complexes to RNA have been herein commented [44,45,47,70,[76][77][78][79][80][81][82][83][84][85][86][87]. Even if the existence of platinum-RNA adducts is undeniable, further biochemical and structural studies are needed to better understand the nature of platinum-RNA adducts as well as their impact on RNA structure and on RNA biological functions.…”

Section: Discussionmentioning

confidence: 95%

“…More recently, they also showed the use of another platinum complex, namely cis-[Pt(2-azido-1,3-propanediamine)Cl 2 ] (Fig. 7a), for the detection of longlived Pt-RNA adducts in rRNA [47].…”

Section: Identifying Platinum-rna Adducts In Cellsmentioning

confidence: 97%

“…DeRose and co-workers have recently developed a convenient and potent method to identify platinum cellular targets [47,86,87]. They showed that platinum complexes containing an azide unit (Fig.…”

Section: Identifying Platinum-rna Adducts In Cellsmentioning

confidence: 98%

“…In the sections below the most recent advances in the elucidation of platinum-RNA interactions are summarized, mainly focusing on examples subsequent to the above-mentioned review [39]. In particular, the following aspects are covered: (i) RNA platination kinetics [45,70,[77][78][79] (Sections 3.1 and 3.2); (ii) some examples of platinum binding to structured RNAs [80], focusing on latest insights into platinum binding to ribosomal RNA [44,76,81] (Section 3.3); (iii) the effect of platination on RNA interference [82][83][84] (Section 3.4); (iv) the use of Pt-RNA adducts to study RNA structure and dynamics [85] (Section 3.5) and (v) recent methods to detect RNA-platinum adducts in cells [47,86,87] (Section 3.6).…”

Section: Platinum Binding To Rnamentioning

confidence: 99%

“…Surprisingly, the RNA binding abilities of small metal complexes, which can bind to RNA both covalently and non-covalently, have been much less explored [3,39,40]. However, a few recently published papers highlight the renewed interest of the scientific community for this topic [41][42][43][44][45][46][47].…”

Section: Introductionmentioning

confidence: 97%

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Covalent and non-covalent binding of metal complexes to RNA

Alberti

Zampakou

Donghi

2016

Journal of Inorganic Biochemistry

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Targeting nucleic acids with metal complexes is an exciting and widely explored field of research. Following the discovery of the anticancer drug cisplatin, a number of metal complexes have been designed, synthesised, and tested for their DNA binding properties. On the contrary, the interaction of metal complexes with RNA has been much less investigated. RNA is an essential biomolecule, involved in a variety of crucial cellular functions, which offers a much wider structural diversity than DNA. As such, RNA represents an attractive target for the design and the development of structure-selective therapeutic and diagnostic agents. A few recent publications describe the ability of various metal complexes to interact with RNA, and the binding of cisplatin and derivatives to RNA is being currently investigated. This short review offers an overview of some recent advances on both covalent and non-covalent interactions of metal complexes with RNA and addresses the potential of targeting RNA non-duplex structures.

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Section: Discussionmentioning

confidence: 95%

Section: Identifying Platinum-rna Adducts In Cellsmentioning

confidence: 97%

Section: Identifying Platinum-rna Adducts In Cellsmentioning

confidence: 98%

Section: Platinum Binding To Rnamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Covalent and non-covalent binding of metal complexes to RNA

Alberti

Zampakou

Donghi

2016

Journal of Inorganic Biochemistry

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Modifications of Nucleosides, Nucleotides, and Nucleic Acids using Huisgen's [3+2] Azide–Alkyne Cycloaddition: Opening Pandora's Box

Amblard

Sari

Bouclé

et al. 2016

Click Reactions in Organic Synthesis

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A Click Chemistry Approach to Targeted DNA Crosslinking with cis‐Platinum(II)‐Modified Triplex‐Forming Oligonucleotides

et al. 2021

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Limitations of clinical platinum(II) therapeutics include systemic toxicity and inherent resistance.M odern approaches,t herefore,s eek new ways to deliver active platinum(II) to discrete nucleic acid targets.I nt he field of antigene therapy, triplex-forming oligonucleotides (TFOs) have attracted interest for their ability to specifically recognise extended duplex DNAtargets.Here,wereport aclickchemistry based approach that combines alkyne-modified TFOs with azide-bearing cis-platinum(II) complexes-based on cisplatin, oxaliplatin, and carboplatin motifs-to generate al ibrary of Pt II -TFO hybrids.T hese constructs can be assembled modularly and enable directed platinum(II) crosslinking to purine nucleobases on the target sequence under the guidance of the TFO.B yc ovalently incorporating modifications of thiazole orange-a knownD NA-intercalating fluorophore-into Pt II -TFOs constructs,e nhanced target binding and discrimination between target and off-target sequences was achieved.

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Convenient detection of metal–DNA, metal–RNA, and metal–protein adducts with a click-modified Pt(ii) complex

Cited by 23 publications

References 28 publications

Covalent and non-covalent binding of metal complexes to RNA

Covalent and non-covalent binding of metal complexes to RNA

Modifications of Nucleosides, Nucleotides, and Nucleic Acids using Huisgen's [3+2] Azide–Alkyne Cycloaddition: Opening Pandora's Box

A Click Chemistry Approach to Targeted DNA Crosslinking with cis‐Platinum(II)‐Modified Triplex‐Forming Oligonucleotides

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