Convenient syntheses of N‐CD<sub>3</sub> labelled nicotine and nicotine analogues

Seeman, Jeffrey I.; Secor, Henry V.; Forrest, Gary T.

doi:10.1002/jlcr.2580160304

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Cited by 10 publications

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Comparison of the binding of optically pure (?)- and (+)-[3H]nicotine to rat brain membranes

1985

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A comparison of the binding of (-)- and (+)-[3H]nicotine to rat brain membranes revealed that only the (-)-enantiomer showed high affinity binding; while the (+)-enantiomer was at least 1/10 as effective as the (-)-enantiomer when in competition with (-)-[3H]nicotine as the ligand. Positive cooperativity, which is observed with (-)-[3H]nicotine in the presence of low concentrations of (+)-nicotine, may account for the seeming paradox.

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Comparison of the binding of optically pure (?)- and (+)-[3H]nicotine to rat brain membranes

1985

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Receptor binding characteristics of a 3H-labeled azetidine analogue of nicotine

Abood¹,

Lu²,

Banerjee³

1987

Biochemical Pharmacology

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Binding of optically pure (−)‐[³H]nicotine to rat brain membranes

1983

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With the recent availability of ( -)-[3H]nicotine of high specific activity, binding studies were performed on rat brain membranes in the presence of a variety of nicotine analogues and cholinergic drugs. Both a higher affinity (& = 2 x lo-" M) and a lower affinity (2 x 10e9 M) site were observed; the stereoselectivity of both sites being similar. A good correlation was observed between Z&-values and psychotropic potency of a series of N'alkyl substituted nicotine analogues. Nicotine receptor Rat brain Nicotine analogue Cholinergic drugNicotine psychopharmacology

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Convenient syntheses of N‐CD₃ labelled nicotine and nicotine analogues

Cited by 10 publications

References 15 publications

Comparison of the binding of optically pure (?)- and (+)-[3H]nicotine to rat brain membranes

Comparison of the binding of optically pure (?)- and (+)-[3H]nicotine to rat brain membranes

Receptor binding characteristics of a 3H-labeled azetidine analogue of nicotine

Binding of optically pure (−)‐[³H]nicotine to rat brain membranes

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Convenient syntheses of N‐CD3 labelled nicotine and nicotine analogues

Cited by 10 publications

References 15 publications

Comparison of the binding of optically pure (?)- and (+)-[3H]nicotine to rat brain membranes

Comparison of the binding of optically pure (?)- and (+)-[3H]nicotine to rat brain membranes

Receptor binding characteristics of a 3H-labeled azetidine analogue of nicotine

Binding of optically pure (−)‐[3H]nicotine to rat brain membranes

Contact Info

Product

Resources

About

Convenient syntheses of N‐CD₃ labelled nicotine and nicotine analogues

Binding of optically pure (−)‐[³H]nicotine to rat brain membranes