Conventional Perimetry, Short-Wavelength Automated Perimetry, Frequency-Doubling Technology, and Visual Evoked Potentials in the Assessment of Patients with Multiple Sclerosis

Corallo, G.; Cicinelli, Simonetta; Papadia, Marina; Bandini, Fabio; Uccelli, Antonio; Calabria, G.

doi:10.1177/112067210501500612

Cited by 25 publications

(15 citation statements)

References 20 publications

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“…Contrary to our study, Corallo et al used a test of central limit 30-2 (76 targets tested). This analysis of the visual field larger than the one given by FDTP, which is limited to 20°, could explain this absence of correlation, as well as the smaller sample size of only fourteen patients [23].…”

Section: Resultsmentioning

confidence: 95%

“…Apart from underlining the campimetric deficits among patients with a previous history of ON, FDTP allowed, among patients without a previous history of ON, the detection of anomalies of the visual field due to an axonal deficit consecutive to infra-clinical demyelinating lesions of the optic nerve [21,22]. FDTP would be more sensitive than SAP in detecting the first campimetric alterations [23]. The large retinal ganglionic cells (M cells) are less numerous and less redundant; their effect would explain more precocious alterations to the visual field.…”

Section: Resultsmentioning

confidence: 98%

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Anatomic and functional correlation of frequency-doubling technology perimetry (FDTP) in multiple sclerosis

et al. 2011

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To study the correlation between the results of frequency-doubling technology perimetry (FDTP), visual function (visual acuity, contrast vision, standard automated perimetry (SAP)) and the thickness of the retinal nerve fiber layer (RNFL) throughout the course of multiple sclerosis (MS). Sixty-six eyes of thirty-three patients suffering from MS were chosen. Thirty-five eyes had a previous history of optic neuritis (ON group) and thirty-one eyes had no previous history of optic neuritis (non-ON group). The FDTP was performed with the N-30 screening program. Visual acuity was determined with the Snellen scale and the ETDRS (Early Treatment Diabetic Retinopathy Study) scale, the contrast vision with the Pelli-Robson and Sloan tests and the SAP with the Humphrey 750 perimeter. The thickness of the RNFL was measured using the STRATUS OCT™ optical coherence tomography (OCT). The visual field FDTP was divided into three sectors corresponding to the three SAP sectors and to the three RNFL quadrants of the OCT. The FDTP was significantly correlated (P<0.0001) to the contrast vision and to the SAP results (mean deviation (MD) and the different sectors among themselves). In the ON group, the MD FDTP was significantly correlated to the average RNFL thickness (r=0.44, P=0.0091). A decrease of 5 decibels (dB) of the MD FDTP corresponded to a decrease of 11.7 μm of the average RNFL thickness (Y=2.34×X+87.5). The strong correlation with SAP and RNFL confirms the value of FDTP in assessing optic nerve damage throughout the course of MS.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 98%

Anatomic and functional correlation of frequency-doubling technology perimetry (FDTP) in multiple sclerosis

et al. 2011

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“…Visual evoked potentials anomalies in 43.7% of MS patients with negative ophthalmological examination were described by Corallo et al (2005), who concluded that a combination of several diagnostic techniques could identify asymptomatic optic nerve impairment. In a similar study group, but one that included subjects with a normal VF examination, we observed 40% of eyes to have a prolonged P100 latency.…”

Section: Discussionmentioning

confidence: 99%

Sub‐clinical atrophy of the retinal nerve fibre layer in multiple sclerosis

Pueyo

Ara

Almárcegui

et al. 2009

Acta Ophthalmologica

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Acta Ophthalmol. 2010: 88: 748–752 Abstract. Purpose: This study aimed to evaluate the presence of abnormalities in the retinal nerve fibre layer (RNFL) in multiple sclerosis (MS) patients with normal ophthalmic examination, and to compare the ability of optical coherence tomography (OCT) and scanning laser polarimetry (GDx) to detect axonal loss. Methods: Patients with MS and disease‐free controls were invited to enrol in the study from 1 February 2007 to 30 June 2008. Ophthalmic examination, including evaluation of visual acuity (VA) and visual field (VF), showed normal results in all subjects. Retinal nerve fibre layer properties were measured by means of OCT and GDx. Visual evoked potentials (VEPs) were also recorded. Results: Forty eyes of 40 MS patients and 20 eyes of age‐ and sex‐matched controls were included in the study. Despite normal VA and VF results, significant differences between the two groups were observed in VF mean deviation (MD), most of the RNFL measurements provided by OCT and GDx, and VEP P100 latency and amplitude. There was a significant correlation between OCT and GDx parameters, and between these parameters and VEP results. Nineteen MS eyes (35.7%) showed RNFL abnormalities detected either by OCT or GDx. Discussion: Sub‐clinical ganglion cell loss can be detected in MS patients with normal visual function. Both OCT and GDx are useful complementary tools with which to identify this damage.

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“…18 Correlations between RNFL morphology and neurophysiology are also reported. 19,20 Consideration of patient quality of life (QOL) is intrinsic to the practice of medicine, particularly when evaluating therapeutic approaches to chronic disease. 21 In PD, fatigue and fatigability levels are higher than in healthy individuals, and are negatively associated with QOL scores.…”

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confidence: 99%

Electrophysiology and Optical Coherence Tomography to Evaluate Parkinson Disease Severity

García‐Martín

Rodríguez-Mena²,

Satué

et al. 2014

Invest. Ophthalmol. Vis. Sci.

105

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Conventional Perimetry, Short-Wavelength Automated Perimetry, Frequency-Doubling Technology, and Visual Evoked Potentials in the Assessment of Patients with Multiple Sclerosis

Cited by 25 publications

References 20 publications

Anatomic and functional correlation of frequency-doubling technology perimetry (FDTP) in multiple sclerosis

Anatomic and functional correlation of frequency-doubling technology perimetry (FDTP) in multiple sclerosis

Sub‐clinical atrophy of the retinal nerve fibre layer in multiple sclerosis

Electrophysiology and Optical Coherence Tomography to Evaluate Parkinson Disease Severity

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