Copaiba Oil Influences Ventral Hernia Repair With Vicryl® Mesh?

Abstract

Background: The use of meshes in hernia surgical repair promoted revolution in the surgical area; however, some difficulties had come, such as a large area of fibrosis, greater postoperative pain and risk of infection. The search for new substances that minimize these effects should be encouraged. Medicinal plants stand out due possible active ingredients that can act on these problems. Aim: To check the copaiba oil influence in the repair of abdominal defects in rats corrected with Vicryl(c) mesh. Method: Twenty-four Wistar rats were submitted to an abdominal defect and corrected with Vicryl(c) mesh. They were distributed into two groups: control and copaíba via gavage, administered for seven days after surgery. The analysis of the animals took place on 8, 15 and 22 postoperative days. It analyzed the amount of adhesions and microscopic analysis of the mesh. Results: There was no statistical difference regarding the amount of adhesions. All animals had signs of acute inflammation. In the control group, there were fewer macrophages in animals of the 8th compared to other days and greater amount of necrosis on day 8 than on day 22. In the copaiba group, the number of gigantocytes increased compared to the days analyzed. Conclusion: Copaiba oil showed an improvement in the inflammatory response accelerating its beginning; however, did not affect the amount of abdominal adhesions or collagen fibers.

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

“…Thus, we have looked at some works with copaiba oil administered via gavage for abdominal adhesion in rats corrected with Vicryl (Ethicon Inc., Somerville, NJ, USA) mesh. 26 The authors demonstrated that although the gavage administration showed no statistically significant difference in adhesions and collagen fibers, the inflammatory response was better in the group that used copaiba oil. Copaiba oil also showed positive effects on bladder healing, 11 and skin healing processes.…”

“…However, we cannot fail to report that the studies found on the healing properties of copaiba did not involve its application oil on the skin exclusively. Yasoshima et al 26 used copaiba oil via gavage in rats that underwent hernia repair with Vicryl mesh. According to the authors, there were no significant results in the postoperative healing process when compared with the control group.…”

Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats

“…It can be divided into three phases: 1 st or exudative inflammation; 2 nd or proliferative/ fibroblastic (granulation tissue with deposition of extracellular matrix); 3 rd or remodeling/maturation [1][2][3][4][5][6] . The knowledge of each of these stages is important to guide appropriate adjuvant therapy to improve biological reaction 6 .…”

The effects of aqueous extract of babassu (Orbignya phalerata) on the pleura and lung parenchyma in rats

“…Several substances have been studied both clinically and experimentally, such as ethanolamine oleate, diazepam, erythromycin, macrolides, quinolones, povidone-iodine, in search of an agent with the following characteristics: effective, widely available, low cost, and few side effects 6 . Currently, the most commonly used agents are talc instilled into the pleural cavity by aspersion or dilution in saline solution, tetracycline derivatives (minocycline and doxycycline), and bleomycin [7][8][9][10] . In the 1980s, tetracycline was the preferred agent for chemical pleurodesis.…”