Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Abstract

Recent studies demonstrated that one of the major components of the copaiba oil, β-caryophyllene, has an anti-inflammatory effect. 4 Copaiba oil is extracted from the copaifera, a Abstract Many medicinal plants are sought as alternative therapies for various conditions, as opposed to synthetic alternatives. The Brazilian Amazon provides a plethora of plants with various therapeutic and medicinal properties. One of them is copaiba oil, a natural product of the biodiversity of the Amazon. The anti-inflammatory and antimicrobial properties of copaiba oil have been drawing the attention of the scientific community as a great alternative in the treatment of illnesses associated with inflammatory and infectious processes. The purpose of the present study is to evaluate and analyze the latest publications on the use of copaiba oil in the PubMed/Medline database from 2014 to 2017. Forty-two articles were collected, verifying anti-inflammatory activity, antimicrobial activity, healing, and antitumor activity. The results found on researches with copaiba oil according to publication dates were 11.9% in 2014, 38.1% in 2015, 16.7% in 2016, and 33.3% in 2017. In the analyzed studies, the proposed administration of copaiba oil was 50% topical, 28.6% oral, 9.5% enteral, 4.8% subcutaneous, and 7.1% others. In the objectives of the presente study in relation to the administration of copaiba oil, the result was 31% antimicrobial, 28.6% anti-inflammatory, 9.5% antitumor, 9.5% healing, and 21% others. Regarding the types of research, we have found 50% in vitro, 40.4% in vivo animals, 2.4% in vivo human, 2.4% review and 4.8% others. Regarding the significance factor evaluation, the result was 100% positive in antitumor activity, 84% positive in infection and inflammation pathology, 62% positive in others, like dental processes, food technology application support and as a drug absorption vehicle, and 50% in healing. The results presented in the current meta-analysis show that copaiba oil is an effective alternative to treatments of illnesses such as chronic inflammation, infectious diseases, various types of cancer, autoimmune diseases, and as a vehicle for the absorption of other drugs. Thus, more studies regarding the benefits of copaiba oil could provide a great contribution to the medical community in the treatment of the aforementioned illnesses.

Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil

“…Second, the effects of copaiba essential oil on neuronal signaling pathways were mediated by CB2. This observation is consistent with the existing literature and supports the suitability of copaiba essential oil for pain relief and anti-inflammatory therapeutic applications [32]. Third, copaiba essential oil exerted differential effects on the pI3K/Akt/mTOR signaling pathway in different cell types.…”

“…The positive regulatory effects of copaiba essential oil peaked at 30 min with an EC 50 of approximately 80 ng/mL and were mediated in part by CB2. The positive effects of copaiba essential oil on neuronal signaling pathways were consistent with its reported functions in metabolism [32], wound healing [33][34][35][36], and anti-inflammation [37][38][39][40][41]. Interestingly, copaiba essential oil also activated the apoptosis signaling pathway in a time-dependent manner and reduced the viability of neuronal cells with an EC 50 of approximately 400 ng/mL.…”

Revestimento bioativo à base de fécula de mandioca (Manihot esculenta) e beterraba acrescido de óleo de copaíba bálsamo (Copaifera officinalis) para conservação de carne bovina in natura

“…Apesar da diferença entre as espécies, estudos já comprovam que o β-cariofileno é o composto presente em maior proporção no óleo de copaíba bálsamo (Copaifera officinalis), sendo considerado um sesquiterpeno natural e possui um caráter antimicrobiano, cicatrizante e anti-inflamatório, de extrema relevância para a saúde. Enquanto o óleo do estudo apresentou aproximadamente 70% dessa substância, em outros estudos (Dias, et al, 2012;Guimarães-Santos, et al, 2012;Ferro, et al, 2018;Arruda, et al, 2019;Francomano, et al, 2019;Sousa, et al, 2020) evidenciaram a presença de apenas 40% a 57% de βcariofileno. As diferentes concentrações relatadas, podem ser atribuídas a época de colheita e sua fonte geográfica (Boskovic, et al, 2015), a época da extração do óleo, se no período ou após a floração, sendo no primeiro caso a atividade a antimicrobiana mais forte (Burt, 2004).…”

Atividade Do Óleo De Copaíba Sobre Radicais Livres Formados Durante a Resposta Inflamatória

“…O uso oral do CO tem ganhado atenção nos últimos anos devido a sua baixa toxicidade e seus poderes antimicrobiano e anti-inflamatório, constituindo-se numa alternativa interessante para tratamentos em patologias como inflamações crônicas, processos infecciosos, vários tipos de câncer, doenças autoimunes e como veículo para a absorção de outras drogas (Ferro et al, 2018).…”