Copper and Zinc Levels in Hair of Both Schizophrenic and Depressed Patients

Ghanem, Abd-Elaziz A.; Ali, Essam; El-Bakary, Amal; El-Morsy, Doaa A.; Elkanishi, Sherif M. H.; Saleh, El-Sayed; El-Said, Hanan

doi:10.21608/mjfmct.2009.53299

Cited by 11 publications

(9 citation statements)

References 19 publications

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“…Although higher levels of Cp were reported by the majority of studies, lower levels of Cp were also found in some studies. In contrary, the normal levels of Cp were shown by other studies in SZ patients than HC group [23,24,28,47]. Higher Cp levels were reported in first episode depression both previously and later antidepressant drug use [48].…”

Section: Discussionmentioning

confidence: 85%

“…Cu concentrations were elevated in the scalp hair of male and female BD patients [42]. Interestingly, Cu levels and Cu/Zn ratios were remarkably higher in women with a past psychiatric history of post-partum depression [28]. Total Cu intake may be oppositely related to depression [43].…”

Section: Discussionmentioning

confidence: 96%

“…Many studies have shown that dysregulation of Cu adversely influences biological processes of several psychiatric disorders including SZ [21][22][23][24][25][26][27][28][29][30], BD [25,[31][32][33], and MD [25,28,34]. The reduced [28,30,35,36], elevated [21][22][23][26][27][28][29]37,38], and unaltered [25,28,39,40] Cu levels in SZ patients have been mentioned in different studies. Higher Cu concentrations were reported in the course of the BD [41].…”

Section: Discussionmentioning

confidence: 99%

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Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Tunç

Atagün

Başbuğ

et al. 2019

Psychiatry and Clinical Psychopharmacology

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OBJECTIVE: In this study, we aimed to study copper metabolism in schizophrenia, bipolar disorder, major depression compared with healthy control. METHODS: This is a single-centered cross-sectional study. The patients with schizophrenia (n = 36), bipolar disorder (n = 37), major depression (n = 40), and healthy control (n = 32) were included in the study. All participants were initially evaluated by a clinical psychiatrist to confirm the appropriate diagnosis using the Structured Clinical Interview for Diagnostic and Statistical Manuel of Mental Disorders-IV (DSM-IV) Axis I Disorders (SCID-I). Serum copper level, ceruloplasmin mass, and ceruloplasmin-ferroxidase activity were measured. One-way ANOVA and Kruskal-Wallis Tests were performed for statistical analyses. RESULTS: Serum ceruloplasmin-ferroxidase activity (χ 2 = 9.11, p = 0.028) demonstrated a significant statistical difference in all groups compared with the control group. Serum ceruloplasmin-ferroxidase activity of the bipolar disorder group was significantly higher than the healthy control group (p = 0.012), major depression group (p = 0.027), and the schizophrenia group (p = 0.019). Erythrocyte sedimentation rate (ESR) (p = 0.028) and waist circumference (p = 0.005) in bipolar disorder group, and the C-reactive protein (CRP) (p < 0.001) and cholesterol (p = 0.043) in the schizophrenia group were found as the determinants of ceruloplasmin-ferroxidase activity. CONCLUSION: In this study, ceruloplasmin-ferroxidase activity is higher in all groups in comparison to the healthy control. The significantly higher ceruloplasmin-ferroxidase activity was shown in bipolar disorder followed by the major depression and schizophrenia. The ceruloplasmin-ferroxidase activity was correlated with erythrocyte sedimentation rate in the bipolar disorder group and with C-reactive protein in the schizophrenia group. Therefore, the ceruloplasmin-ferroxidase activity may be an encouraging candidate in the neuro-immune modulation and become a reliable clinical tool for demonstrating the strong association of inflammation in these disorders.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Tunç

Atagün

Başbuğ

et al. 2019

Psychiatry and Clinical Psychopharmacology

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“…There is also evidence that greater zinc levels or zinc supplementation are associated with greater sleep quality and quantity; however, the modulation of neural excitability caused by zinc may underlie these findings 6 . An increased excitability/inhibition ratio is thought to play a key role in the pathology of autism and schizophrenia 7 , 8 , and interestingly, children with autism (but not adults were shown to have robustly low hair zinc levels in the huge sample 9 and patients with schizophrenia were shown to have low hair zinc levels in multiple studies 10 , 11 and they also show substantially reduced brain zinc levels 12 . Zinc deficits are also known to lead to socializing deficits 13 .…”

Section: Introductionmentioning

confidence: 99%

Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms

Takeuchi

Taki

Nouchi

et al. 2020

Sci Rep

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Zinc is a biologically essential element and involved in a wide range of cellular processes. Here, we investigated the associations of zinc levels in hair with brain activity during the n-back working memory task using functional magnetic resonance imaging, fractional anisotropy (FA) of diffusion tensor imaging, and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that greater hair zinc levels were associated with lower brain activity during working memory in extensive areas in the default mode network (i.e., greater task-induced deactivation) as well as greater FA in white matter areas near the hippocampus and posterior limbs of the internal capsule. These findings advance previous non-neuroimaging findings of zinc’s associations with excitability, excitability-associated disorders, and myelination.

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“…The altered amounts of trace elements have been linked to reduced cognitive functions in the elderly (Lam et al, 2008;Smorgon et al, 2004). Furthermore, previous studies reported that the serum or tissue levels of several trace elements are altered in patients with SCZ; they developed the trace element hypothesis of SCZ (Ghanem et al, 2009;Yanik, Kocyigit, Tutkun, Vural, & Herken, 2004). Such findings were followed by a great body of interventions to search for possible biological markers representing the altered levels of trace elements in SCZ (Cai et al, 2015;Fryar-Williams & Strobel, 2015;Lin et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Comparing Copper Serum Level and Cognitive Functioning in Patients With Schizophrenia and Healthy Controls

Mazhari

Arjmand

Shahrbabaki

et al. 2020

BCN

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Introduction: The altered serum profiles of several trace elements have been reported in Schizophrenia (SCZ). This study was designed to elucidate whether the serum levels of Copper (Cu) and Magnesium (Mg), the two essential trace elements which contribute to neurotransmitter transmission, are altered in patients with SCZ. We also investigated whether there is an interrelation between cognitive functioning and the serum levels of Cu and Mg. Methods: Sixty patients with SCZ and 30 healthy controls participated in this study. The patient group was divided into the following: i) early patients (n=35, ≤5 years of illness initiation), and ii) chronic patients (n=25, ≥5 years of illness duration). The serum levels of Cu and Mg were measured by atomic absorption spectroscopy and ion-selective electrode potentiometry, respectively. To assess cognitive abilities, a Persian adaptation of the Brief Assessment of Cognition in Schizophrenia (BACS) was administered. Results: The present research results revealed significantly higher Cu serum levels in both patient groups [early patients (M=94.6), chronic patients (M=97.5)], compared to the controls (M=71.0) (P<0.001); however, no significant difference was observed among the study groups for Mg [patients with the recent onset (M=2.0), chronic patients (M=2.0), and controls (M=1.9)] P=0.1. While the serum Cu profile of healthy individuals revealed a negative correlation with working memory (r=-0.42, P=0.02), and executive functioning (r=-0.40, P=0.03), no significant correlation was observed between Cu serum levels of patients and BACS cognitive domains. Conclusion: findings suggested that the high Cu serum concentration might impact the cognitive decline in healthy individuals; however, no significant correlation was observed in the Patients; i.e. most likely because cognition is severely impaired in SCZ. Additional studies examining trace elements in drug-naïve patients with SCZ are required.

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Copper and Zinc Levels in Hair of Both Schizophrenic and Depressed Patients

Abstract: Ghanem et al ... essential trace elements that have been studied in many diseases, including autoimmune, neurologic and psychiatric disor-INTRODUCTlON Copper (Cu) and zinc (Zn) are two COPPER AND ZINC LEVELS IN HAIR OF BOTH SCHIZOPHRENIC

Cited by 11 publications

References 19 publications

Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms

Comparing Copper Serum Level and Cognitive Functioning in Patients With Schizophrenia and Healthy Controls

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